Serum uric acid in patients with acute ST-elevation myocardial infarction

Chen, Li; Li, Xianlun; Qiao, Wei; Ying, Zhe; Qin, Yanli; Wang, Yong; Zeng, Yujie; Yuan, Ke

doi:10.5847/wjem.j.issn.1920-8642.2012.01.006

Cited by 25 publications

(20 citation statements)

References 15 publications

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“…12 The increase in serum uric acid in patients with cardiovascular disease may reflect a compensatory mechanism to counter the oxidative stress that occurs with tissue hypoxia, thus, the higher levels of uric acid corresponding to high risk may reflect response to tissue injury, whereas the higher risk at lower levels of uric acid levels may be the result of decreased antioxidant capacity. 13,14,15 Evidence for involvement of uric acid in cardiovascular disease is extensive, and so are the controversies surrounding the interpretation of the data. 14,15,16,17 This study has been taken up to determine serum uric acid levels in Acute Coronary Syndromes (ACS) and to compare the incidence of complications in hyperuricaemic and normouricaemic ACS patients.…”

Section: Introductionmentioning

confidence: 99%

“…13,14,15 Evidence for involvement of uric acid in cardiovascular disease is extensive, and so are the controversies surrounding the interpretation of the data. 14,15,16,17 This study has been taken up to determine serum uric acid levels in Acute Coronary Syndromes (ACS) and to compare the incidence of complications in hyperuricaemic and normouricaemic ACS patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Uric Acid in Acute Coronary Syndromes

Marak¹,

Thongam²,

Hijam³

et al. 2019

IJCMR

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid in Acute Coronary Syndromes

Marak¹,

Thongam²,

Hijam³

et al. 2019

IJCMR

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“…7,12 Asam urat mendorong perkembangan terjadinya aterosklerosis. 13 Pecahnya plak aterosklerosis dengan pembentukan trombus dan oklusi pembuluh koroner menyebabkan penurunan pasokan darah secara akut ke sebagian miokardium sehingga terjadi infark mio-kard. 14 Pada pasien infark miokard dengan kadar asam urat tinggi dapat terjadi peningkatan angka kematian.…”

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Gambaran Kadar Asam Urat pada Pasien Infark Miokard Akut di RSUP Prof. Dr. R. D. Kandou Manado Periode September 2016 – Agustus 2017

Gonie¹,

Wantania²,

Umboh³

2017

eCl

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Acute myocardial infarction (AMI) is a cardiovascular disease that becomes one of the leading causes of death worldwide. Rupture of atherosclerotic plaque followed by thrombus formation and occlusion of coronary arteries causes an acute decrease in the blood supply to some parts of myocardium resulting in myocardial infarction, associated with inflammatory responses that may cause increased uric acid level. Patients of myocardial infarction accompanied by high uric acid level have higher mortality rate. This study was aimed to determine the description of uric acid level in patients with AMI at Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study using medical record data of patients with AMI hospitalized at Prof. Dr. R. D. Kandou Hospital Manado in the period of September 2016 until August 2017. The results showed 92 AMI cases (60.1%) who had elevated uric acid level. The majority of AMI cases were males (115 patients; 75.2%), aged 51-60 years old, (52 patients; 34%), Minahasan ethnic (138 cases; 90.2%), and had no family history of high uric acid level (24 cases; 15.7%). Conclusion: The majority of the patients with AMI had elevated uric acid level.Keywords: acute myocardial infarction, uric acid, inflammatory response. Abstrak: Infark miokard akut (IMA) merupakan penyakit kardiovaskular yang menjadi salah satu penyebab kematian di dunia. Pecahnya plak aterosklerosis dengan pembentukan trombus dan oklusi pembuluh koroner menyebabkan penurunan pasokan darah secara akut ke sebagian miokardium sehingga terjadi infark miokard, diikuti respon inflamasi yang menyebabkan asam urat meningkat. Pada pasien IMA dengan kadar asam urat tinggi dapat terjadi peningkatan angka kematian. Penelitian ini bertujuan untuk mengetahui gambaran kadar asam urat pada pasien IMA di RSUP Prof. Dr. R. D. Kandou Manado periode September 2016 sampai Agustus 2017. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien IMA yang dirawat di RSUP Prof. Dr. R. D. Kandou Manado periode September 2016 sampai Agustus 2017. Hasil penelitian memperlihatkan 92 kasus IMA (60,1%) memiliki kadar asam urat meningkat. Mayoritas kasus IMA berjenis kelamin laki-laki (115 pasien; 75,2%), usia 51-60 tahun (52 pasien; 34%), suku Minahasa (138 pasien; 90,2%), dan tidak memiliki riwayat keluarga asam urat (24 pasien; 15,7%). Simpulan: Sebagian besar pasien dengan IMA memiliki kadar asam urat yang meningkat.Kata kunci: infark miokard akut, asam urat, respon inflamasi

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“…One of the most effective treatments for ACS, which has been shown to reduce mortality and improve the quality of life, is elective or emergency percutaneous coronary intervention (PCI) [2]; however, several risk factors are associated with repeat revascularization and other adverse events after PCI [3]. Several biomarkers, such as C-reactive protein, creatine kinase (CK), CK-MB, hyperuricemia, serum total bilirubin (STB), and troponin-T, have been shown to predict adverse cardiac events after PCI [4,5,6].…”

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confidence: 99%

Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention

Zhang

Kan

Yao

et al. 2014

CIM

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Purpose: The purpose of this study was to investigate the associated between serum total bilirubin (STB) levels and long-term outcomes in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods: A total of 1,273 consecutive patients were enrolled. Patients were grouped according to their baseline STB levels: Group 1 (STB < 3.4 μmol/L), Group 2 (3.4 μmol/L ≤ STB ≤ 10.3 μmol/L), Group 3 (10.3 μmol/L < STB ≤ 17.1 μmol/L), and Group 4 (STB > 17.1 μmol/L) and the rate of major adverse cardiovascular events (MACE) was determinedResults: A total of 1,152 patients were successfully followed up (90.5%) for a mean period of 30 ± 5 months, including 187 patients experiencing a major adverse cardiovascular event (MACE: death from any cause, myocardial infarction, repeat revascularization or readmission). The MACE rate in Groups 3 and 4 was lower than in Groups 1 and 2 (P < 0.01). After adjusted the confounding factors with Cox regression analysis, the MACE rates in Groups 2-4 were still lower than in Group 1 (Group 2, RR=0.293, 95% CI 0.167-0.517, P<0.01; Group 3, RR=0.142, 95% CI 0.065-0.312, P<0.01; Group 4, RR=0.134, 95% CI 0.071-0.252, P<0.01). The cumulative survival rates of Groups 3 and 4 were higher than that of Groups 1and 2 (P<0.01).Conclusions: High STB concentration is associated with lower MACE in patients with ACS after PCI.

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Serum uric acid in patients with acute ST-elevation myocardial infarction

Cited by 25 publications

References 15 publications

Serum Uric Acid in Acute Coronary Syndromes

Serum Uric Acid in Acute Coronary Syndromes

Gambaran Kadar Asam Urat pada Pasien Infark Miokard Akut di RSUP Prof. Dr. R. D. Kandou Manado Periode September 2016 – Agustus 2017

Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention

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