Prognostic significance of temporal changes of lipid profile in COVID-19 patients

Barman, Hasan Ali; Pala, Ayşe Selcen; Doǧan, Ömer Tamer; Atıcı, Adem; Yumuk, Mehmet Tugay; Alıcı, Gökhan; Sit, Omer; Güngör, Barış; Doğan, Sait Mesut

doi:10.1016/j.obmed.2021.100373

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…Studies emanating from Turkey report that lipid levels and temporal changes in lipid profiles predict short-term mortality in patients with COVID-19 [ 30 , 31 ]. The future studies are needed to learn about the consequences of long-term metabolic dysregulations after COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with those studies, TC, LDL-C, and HDL-C levels were lower, and TG levels were higher in the non-survivor group of this study. Studies emanating from Turkey report that lipid levels and temporal changes in lipid profiles predict short-term mortality in patients with COVID-19 (31,32). Future studies are needed to learn about the consequences of long-term metabolic dysregulations after COVID-19.…”

Section: Qin Et Al Reported Reductions In Tc and Ldl-c Levels In A Re...mentioning

confidence: 99%

“…Coronavirus disease 2019 is associated with a decrease in lipid levels, which serves as an indicator of the severe inflammatory burden. Inflammatory cytokine storms increase the mortality rate in COVID-19 (32). The consequences of long-term metabolic dysregulations in the recovered patients from COVID-19 still need to be understood.…”

Section: Qin Et Al Reported Reductions In Tc and Ldl-c Levels In A Re...mentioning

confidence: 99%

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Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences

Baycan¹,

Bölen²,

Atalay³

et al. 2022

Bosn J of Basic Med Sci

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Coronavirus disease 2019 (COVID-19) is diagnosed by the evidence of the presence of multiple phenotypes, including thrombosis, inflammation, and alveolar and myocardial damage, which can cause severe illness and mortality. High-density lipoprotein cholesterol (HDL-C) has pleiotropic properties, including anti-inflammatory, anti-infectious, antithrombotic, and endothelial cell protective effects. The aim of this study was to investigate the HDL-C levels and one-year mortality after the first wave of patients with COVID-19 were hospitalized. Data from 101 patients with COVID-19 were collected for this single-center retrospective study. Lipid parameters were collected on the admission. The relationship between lipid parameters and long-term mortality was investigated. The mean age of the non-survivor group (n = 38) was 68.8 ± 14.1 years, and 55% were male. The HDL-C levels were significantly lower in the non-survivors group compared with the survivors (26.9 ± 9.5 vs 36.8 ± 12.8 mg/dl, respectively p < 0.001). Multivariate regression analysis determined that age, C-reactive protein, D-dimer, hypertension, and HDL-C as independent predictors for the development of COVID-19 mortality. HDL-C levels <30.5 mg/dl had 71% sensitivity and 68% specificity to predict one-year mortality after COVID-19. The findings of this study showed that HDL-C is a predictor of one-year mortality in Turkish patients with COVID-19. COVID-19 is associated with decreased lipid levels, and it is an indicator of the inflammatory burden and increased mortality rate. The consequences of long-term metabolic dysregulations in patients that have recovered from COVID-19 still need to be understood.

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Section: Discussionmentioning

confidence: 99%

Section: Qin Et Al Reported Reductions In Tc and Ldl-c Levels In A Re...mentioning

confidence: 99%

Section: Qin Et Al Reported Reductions In Tc and Ldl-c Levels In A Re...mentioning

confidence: 99%

See 1 more Smart Citation

Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences

Baycan¹,

Bölen²,

Atalay³

et al. 2022

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

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“…Interestingly, a 12-year follow-up of subjects who had recovered from the previous coronavirus illness, SARS, revealed that subjects who had been previously infected by SARS experienced a higher incidence of derangements in lipid profile, altered glucose metabolism as well as cardiovascular problems as compared to volunteers who were matched for age and body mass index. 30 Furthermore, a recent study carried out by Barman et al 31 in COVID-19 patients showed that temporal changes in lipid parameters before and after COVID-19 may be associated with mortality and in-hospital adverse outcomes. This is in keeping with the findings of Masana et al 32 who showed that low HDL-cholesterol and high triglyceride concentrations measured before or during hospitalisation are strong predictors of a severe COVID-19; the authors suggest that these could be sensitive markers of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes at medium-term follow-up of COVID-19

Barbara

Gatt

Xuereb

et al. 2022

Journal of the Royal College of Physicians of Edinburgh

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Background: The long coronavirus disease 2019 (COVID-19) syndrome is defined as persistent physical, cognitive and/or psychological symptoms that continue for more than 12 weeks following the acute illness. Methods: In all, 2,646 patients were randomly selected from all individuals who were diagnosed with COVID-19. They were interviewed so as to assess the persistence of symptoms and health-related quality of life. Blood investigations were also taken. Results: The median (interquartile range (IQR)) age was 44 (31–55) years and 48.6% were males. Five per cent had been hospitalised. Follow-up was for a median of 142 days (IQR: 128–161). Twenty-two per cent of the participants claimed that they were feeling worse than they felt before COVID-19. The most common symptoms were anosmia, ageusia, fatigue, shortness of breath, headaches and myalgia. The Short Form-36 questionnaire revealed that 16.4% felt that they were somewhat worse than in the previous year and that hospitalised patients fared worse in all domains except for role-emotional. New-onset diabetes was similar to the rate of undiagnosed diabetes in the background population. Hospitalised patients had significantly higher liver transaminases, fasting plasma glucose, glycated haemoglobin, uric acid, red cell distribution width, mean platelet volume, triglyceride levels and troponin levels but lower estimated glomerular filtration rate and high-density lipoprotein-cholesterol at follow-up. Discussion: A significant proportion of patients were symptomatic at a median follow-up of 142 days and felt worse than 1 year previously. Hospitalised patients had more biochemical and haematological abnormalities compared to non-hospitalised ones, suggesting ongoing inflammation in subjects who were more severely affected by the disease.

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NAFLD determined by Dallas Steatosis Index is associated with poor outcomes in COVID-19 pneumonia: a cohort study

et al. 2022

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Coronavirus disease 2019 is a worldwide health challenge. Liver steatosis diagnosis based on imaging studies has been implicated in poor outcomes of COVID-19 pneumonia, but results are inconsistent. The Dallas Steatosis Index (DSI) is an available calculator developed to identify patients with non-alcoholic fatty liver disease (NAFLD). We hypothesized that it would be associated with in-hospital mortality, intensive care unit admission (ICU), and invasive mechanical ventilation (IMV). We conducted a retrospective cohort study on inpatients with confirmed COVID-19 pneumonia between February 26 and April 11, 2020. We computed the DSI on admission, and patients with high DSI were considered with NAFLD. We employed logistic regression to study the association between NAFLD, mortality, ICU admission, and IMV. We studied the association between liver steatosis on computed tomography (CT) and these outcomes, and also between Metabolic Associated Fatty Liver Disease (MAFLD) based on CT findings and risk factors and the outcomes. 470 patients were included; 359 had NAFLD according to the DSI. They had a higher frequency of type 2 diabetes (31% vs 14%, p < 0.001), obesity (58% vs 14%, p < 0.001), and arterial hypertension (34% vs 22%, p = 0.02). In univariable analysis, NAFLD was associated with mortality, ICU admission, and IMV. Liver steatosis by CT and MAFLD were not associated with any of these outcomes. In multivariable logistic regression, high DSI remained significantly associated with IMV and death. High DSI, which can be easily computed on admission, was associated with IMV and death, and its use to better stratify the prognosis of these patients should be explored. On the other hand, liver steatosis by CT and MAFLD were not associated with poor outcomes.

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Prognostic significance of temporal changes of lipid profile in COVID-19 patients

Cited by 3 publications

References 28 publications

Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences

Prognostic significance of HDL-C on long-term mortality in patients with COVID-19 pneumonia in the Turkish population: A potential mechanism for population differences

Clinical outcomes at medium-term follow-up of COVID-19

NAFLD determined by Dallas Steatosis Index is associated with poor outcomes in COVID-19 pneumonia: a cohort study

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