Prognostic significance of pleural lavage cytology immediately after thoracotomy in patients with lung cancer

Kondo, Haruhiko; Asamura, Hisao; Suemasu, Keiichi; Goya, Tomoyuki; Tsuchiya, Ryosuke; Naruke, Tsuguo; Yamagishi, Kazumasa; Uei, Yoshio

doi:10.1016/s0022-5223(19)33983-2

Cited by 99 publications

(35 citation statements)

References 14 publications

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“…37 Environment-Related Factors: A full description of therapeutic options and their efficacy is beyond our intended scope in this article. Medical decision making must consider at least two conditional prognoses (eg, the prognosis with one treatment and the prognosis with an alternative treatment), hence, the prognostic significance of a therapeutic intervention 10,80 "N" factor 46,[80][81][82] Weight loss 51,52 Hypercalcemia 54 Performance status 55 Additional factors Anatomic Sex 52 "T" factor 46,[83][84][85][86][87] Tumor size [88][89][90] Age 91,92 Nodal level 86,93 Pleural cytology 63,94,95 Intrapulmonary metastasis 96…”

Section: Tumor-related Factorsmentioning

confidence: 99%

Prognostic Factors in Non-small Cell Lung Cancer

Brundage

Davies

Mackillop

2002

Chest

515

334

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Section: Tumor-related Factorsmentioning

confidence: 99%

Prognostic Factors in Non-small Cell Lung Cancer

Brundage

Davies

Mackillop

2002

Chest

515

334

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“…Brewer speculated that VPI may lead to diffuse dissemination of cancer cells throughout the pleural cavity by pleural effusion . Previous studies have also reported a close correlation between VPI and malignant pleural effusion …”

Section: Discussionmentioning

confidence: 99%

Extent of visceral pleural invasion and the prognosis of surgically resected node‐negative non‐small cell lung cancer

2017

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BackgroundVisceral pleural invasion (VPI) is generally considered a poor prognostic factor in non‐small cell lung cancer (NSCLC). VPI is defined as penetration beyond the elastic layer of visceral pleura (PL1), including the visceral pleural surface without the involvement of adjacent structures (PL2) by cancer cells. The aim of this study was to evaluate the influence of the extent of VPI on NSCLC prognosis.MethodsThis was a retrospective study of 90 patients with resected node‐negative NSCLC with VPI. The overall survival (OS) and disease‐free survival (DFS) rates were estimated using the Kaplan–Meier method. Multivariate analysis for prognostic factors was performed using a Cox proportional hazards regression model. The pattern of recurrence was also compared between PL1 and PL2 groups.ResultsSeventy‐three patients had PL1. The three‐year OS rates for the PL1 and PL2 groups were 97.4% and 82.4%, respectively (P = 0.004). The two‐year DFS rates for PL1 and PL2 groups were 81.0% and 76.5%, respectively (P = 0.419). According to the multivariate analysis, PL2 was not a significant prognostic factor for survival outcome in node‐negative NSCLC with VPI compared to PL1 (hazard ratio for DFS 1.753, 95% confidence interval 0.582–5.284; P = 0.319). In this study, six patients in the PL1 and one in PL2 group developed ipsilateral pleural recurrence (P = 1.000).Conclusion VPI extent may not influence survival outcomes in patients with surgically resected node‐negative NSCLC with VPI.

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“…The 5-year survival rate was 23.3% for the patients with positive PLC, and the survival curve was similar to that for patients with advanced disease. Kondo and colleagues [2] reported that patients with positive PLC showed survival equal to that in patients with stage IIIB or IV. Our result was similar to these findings.…”

Section: Discussionmentioning

confidence: 99%

“…The present result showed that the ratio of positive PLC patients was 7.48% (30/401). The frequency of positive results in the literature varies according to amount of solution used, timing of the procedure, and the center, but in general is less than 10% in the larger published series [2]- [11].…”

Section: Discussionmentioning

confidence: 99%

“…Pleural lavage cytology (PLC) is the microscopic study of cells obtained from saline instilled into and retrieved from the chest cavity (in patients without preoperative pleural effusion) during surgery for non-small cell lung cancer (NSCLC). Since its first use in 1958 [1], several studies, including meta-analytical studies, have clearly demonstrated a link between the presence of malignant cells in PLC and poor prognosis [2]- [11]. These concluded that positive PLC is a strong prognostic factor for survival.…”

Section: Introductionmentioning

confidence: 99%

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Five-Year Survivors of Non-Small Cell Lung Cancer Patients with Positive Pleural Lavage Cytology

Tomita¹,

Ayabe²,

Chosa³

et al. 2014

ALC

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Background: The pleural lavage cytology (PLC) for non-small cell lung cancer (NSCLC) patients has been reported as a significant prognostic factor. The aim of this study is to clarify the clinicopathological characteristics of 5-year survivors of patients with positive PLC. Methods: Among 401 resected NSCLC patients, 30 (7.48%) patients with positive PLC were reviewed retrospectively. Results: Only 7 of 30 patients (23.3%) survived more than 5-year. There were no differences in age, gender, histology, pT status and pN status between 5-year survivors and non-survivors. On the other hand, the serum carcinoembryonic antigen (CEA) level was significantly higher in non-survivors. Among these 5-year survivors, 4 of 7 patients died of NSCLC recurrences more than 5 years after surgery. Remaining 3 patients survived without cancer recurrences. Interestingly these 3 survivors had not received any adjuvant therapies after surgery. Conclusion: None of the 5-year survivor with positive PLC had high serum CEA level. Furthermore 5-year survival did not equal to cure in NSCLC patients with positive PLC.

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Prognostic significance of pleural lavage cytology immediately after thoracotomy in patients with lung cancer

Cited by 99 publications

References 14 publications

Prognostic Factors in Non-small Cell Lung Cancer

Prognostic Factors in Non-small Cell Lung Cancer

Extent of visceral pleural invasion and the prognosis of surgically resected node‐negative non‐small cell lung cancer

Five-Year Survivors of Non-Small Cell Lung Cancer Patients with Positive Pleural Lavage Cytology

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