Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy

Ponce, Frédérique; Magnol, J. P.; Ledieu, D.; Marchal, Thierry; Turinelli, Vanessa; Chalvet‐Monfray, Karine; Fournel‐Fleury, C.

doi:10.1016/j.tvjl.2003.10.009

Cited by 179 publications

(202 citation statements)

References 27 publications

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“…One of the studies reported that the first remission duration and the overall survival time were significantly different among the subtypes of lymphomas [17]. It was also reported in another canine research that both intra-and inter-observer reproducibilities were good in the updated Kiel classification [22].…”

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confidence: 90%

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Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino

Fujino

Kobayashi

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Of the various classification systems for non-Hodgkin's lymphoma, the updated Kiel classification is valuable for veterinary practice, because of its utility to classify the subtypes not only by histopathology but also by cytomorphology. However, there are only a few reports of small number of feline lymphomas to apply the updated Kiel classification. In this study, immunogical subtypes and morphology of 76 feline lymphomas were evaluated and classified into subtypes of the updated Kiel classification. Of the cases, 49% were T-cell lymphoma, 25% were B-cell lymphoma and 26% were undetermined immunological subtype. Based on the updated Kiel classification, most subtypes were identified also in feline lymphomas as in dogs and humans. Globule leukocyte lymphoma was specific for cats and relatively common in feline alimentary lymphomas. Of the present cases, 64% were high-grade subtypes, whereas 36% were low-grade subtypes. The present study indicated that feline lymphomas could be morphologically classified by the modified updated Kiel classification.

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confidence: 90%

“…In veterinary clinical science, some studies indicate that the updated Kiel classification is applicable to canine lymphomas [6,7,17,19,22]. One of the studies reported that the first remission duration and the overall survival time were significantly different among the subtypes of lymphomas [17].…”

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confidence: 99%

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino

Fujino

Kobayashi

et al. 2013

The Journal of Veterinary Medical Science

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“…Its application has been reported in illness such as canine transmissible venereal tumor (CTVT) (Rogers et al, 1998;Nak et al, 2005), lymphomas (Poncé et al, 2004;Rodaski e Nardi, 2006), leukemia (Rodaski and Nardi, 2006) and kidney nephroblastoma (Seaman and Patton, 2003).…”

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confidence: 99%

Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate

Martins

Lopes

Mazzanti

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) -physiologic solution, G2-vincristine sulphate (4mg/m 2 ), G3-physiologic solution, G4-physiologic solution, G5-vincristine sulphate (4mg/m 2 ), and G6-vincristine sulphate (4mg/m 2 ). In the second week, they were: G1 (control) -physiologic solution, G2-physiologic solution, G3-nandrolone decanoate (1.8mg/kg -1 ), G4-nandrolone decanoate (10mg/kg -1 ), G5-nandrolone decanoate (1.8mg/kg -1 ), and G6-nandrolone decanoate (10mg/kg -1 ). Lipid peroxidation increased with the isolated use of vincristine and nandrolone decanoate, and with vincristine associated to the highest dose of the ester as well. These results suggest that vincristine sulphate and nandrolone decanoate increase free radical production. Therapeutic dose of nandrolone decanoate when associated with vincristine sulphate proved to be beneficial, as it was able to protect the organism from damaging processes involved in free radical production.Keywords: rat, anabolic androgenic steroid, chemotherapeutic, free radicals, brain, blood serum RESUMO Este estudo teve por objetivo detectar a peroxidação lipídica presente no cérebro e no soro de ratos tratados com sulfato de vincristina e diferentes doses de decanoato de nandrolona. Trinta ratos foram distribuídos em seis grupos (n=5). Os tratamentos foram aplicados uma vez por semana, durante duas semanas, e a coleta de amostras foi realizada na terceira semana. Na primeira semana, os tratamentos consistiram de: G1(controle) -solução fisiológica; G2 -sulfato de vincristina (4mg/m 2 ); G3 -solução fisiológica; G4 -solução fisiológica; G5 -sulfato de vincristina (4mg/m 2 ) e G6 -sulfato de vincristina (4mg/m 2 ). Na segunda semana: G1(controle)-

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“…Further subclassification within the T‐cell phenotype has identified important subtypes that are associated with both aggressive disease (pleomorphic mixed/peripheral T cell, plasmacytoid, T‐cell lymphoblastic) and indolent disease (small clear cell/T zone lymphoma) 1, 2. This distinction, important for both prognosis and rational selection of chemotherapy protocol, is currently made by histologic examination of tissue specimens.…”

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confidence: 99%

Flow Cytometric Characterization and Clinical Outcome of CD4+ T‐Cell Lymphoma in Dogs: 67 Cases

Avery

Burton

Bromberek

et al. 2014

Veterinary Internal Medicne

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BackgroundCanine T‐cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL is reported to be the most common subtype of TCL. We assessed flow cytometric characteristics, histologic features when available, and clinical outcomes of CD4+ TCL to determine if flow cytometry can be used to subclassify this group of lymphomas.ObjectiveTo test the hypothesis that canine CD4+ T‐cell lymphoma (TCL) is a homogeneous group of lymphomas with an aggressive clinical course.AnimalsSixty‐seven dogs diagnosed with CD4+ TCL by flow cytometry and treated at 1 of 3 oncology referral clinics.MethodsRetrospective multivariable analysis of outcome in canine CD4+ TCL including patient characteristics, treatment, and flow cytometric features.ResultsThe majority of CD4+ TCL were CD45+, expressed low class II MHC, and exhibited an aggressive clinical course independent of treatment regimen (median survival, 159 days). Histologically, CD4+ TCL were classified as lymphoblastic or peripheral T cell. Size of the neoplastic lymphocytes had a modest effect on both PFI and survival in this group. A small number of CD4+ TCL were CD45− and class II MHC high, and exhibited an apparently more indolent clinical course (median survival not yet reached).Conclusions and Clinical ImportanceAlthough the majority of CD4+ TCL in dogs had uniform clinical and flow cytometric features and an aggressive clinical course, a subset had a unique immunophenotype that predicts significantly longer survival. This finding strengthens the utility of flow cytometry to aid in the stratification of canine lymphoma.

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Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy

Cited by 179 publications

References 27 publications

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate

Flow Cytometric Characterization and Clinical Outcome of CD4+ T‐Cell Lymphoma in Dogs: 67 Cases

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