Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate

Martins, Danieli Brolo; Lopes, Sonia T.A.; Mazzanti, Cinthia M.; Spanevello, Rosélia Maria; Schmatz, Roberta; Junior, Marcos Corrêa; Stefanello, Naiara; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria; Veiga, Angela Patricia Medeiros

doi:10.1590/s0102-09352011000100017

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…Although saffron treatments can protect the liver against vincristine sulfate, the mechanism in which saffron extracts improve these abnormalities is not well clear. Recent evidence has indicated that overproduction of free radicals and oxidative stress is one of the significant mechanisms in which vincristine sulfate causes tissue injuries (Martins et al, 2011). Inhibition of oxidative stress (OS) induced by vincristine sulfate and reactive oxygen species (ROS) seem to be one of the mechanisms by which saffron extract improves liver injury.…”

Section: Discussionmentioning

confidence: 99%

The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

Harchegani

Khor

Niha

et al. 2019

Interdisciplinary Toxicology

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Vincristine (VCR) is an important anti-cancer drug, which is highly toxic for the liver. This study aimed at evaluating the protective effect of alcoholic extract of saffron stigma against vincristine hepatotoxicity in the rat. A total number of 50 rats were randomly divided into 10 groups, including controls, rats receiving 0.25 mg/kg (A group), 0.5 mg/kg (B group), 0.75 mg/kg (C group) VCR, 0.25 mg/kg VCR + 0.5 mg/kg saffron (D group), 0.5 mg/kg VCR + 0.5 mg/kg saffron (E group), 0.75 mg/kg VCR + 0.5 mg/kg saffron (F group), 0.25 mg/kg VCR + 1mg/kg saffron (G group), 0.5 mg/kg VCR + 1 mg/kg saffron (H group), and 0.75 mg/kg VCR + 1 mg/kg saffron (I group) groups. Serum level of liver enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin were measured using specific kits at the end of the experimental period. Serum total antioxidant capacity (TAC) and malondialdehyde (MDA) values were measured using ferric reducing antioxidant of power (FRAP) and thiobarbituric acid reaction (TBAR) methods, respectively. Administration of VCR, especially at the concentration of 0.75mg/kg, caused severe hepatic injury with significant increase in the levels of AST (582.0±39.45 UI), ALT (124.0±5.92 UI), ALP (939.8±89.8 UI) enzymes and bilirubin (0.17±0.008). VCR administration also significantly increased the serum MDA level (0.49±0.021 nmol/ml), while TAC value was declined significantly (241.27±18.27 μmol/l). These effects were dose-dependent. Treatment with saffron extract decreased the activity of liver enzymes and MDA values in hepatotoxic rats with a significant enhancement in serum TAC content. These effects were notable for rats that received 1mg/kg plant extract. Administration of saffron, especially at higher concentration, can reduce VCR-induced hepatotoxicity, antioxidant depletion and lipid peroxidation, presumably due to its antioxidative properties.

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Section: Discussionmentioning

confidence: 99%

The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

Harchegani

Khor

Niha

et al. 2019

Interdisciplinary Toxicology

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“…In addition, vincristine is capable of interfering with vascular blood flow and inducing cell necrosis 22 . However, vincristine has been reported to be highly toxic to other non-neoplastic tissues and cause respiratory failure, neuromuscular, cardiac and gastrointestinal toxicities 23 . Signs of hepatotoxicity, including significantly high levels of hepatic transaminase, centrilobular hemorrhagic necrosis, and histological and ultrastructural changes have been observed in patients or animal models treated with vincristine 24 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model

Rocha¹,

Oliveira²,

Azevedo³

et al. 2019

Acta Cir. Bras.

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Purpose:To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats.Methods:We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, hematology and histopathology were used to validate the treatments.Results:All animals survived. A gradual weight gain in all groups was observed, with no significant difference (p>0.05). The oral administration of ACE and ACE+vincristine 50% significantly reduced breast tumors incidence examined with PET-18FDG and fluorescence (p<0.001). Significant reduction of serum transaminases, oxidative stress and hematological toxicity were observed in these groups. Antioxidant enzyme levels in breast tissue were significantly higher compared to the DMBA and DMBA+vincristine groups.Conclusion:These results demonstrate for the first time that ACE positively influences the treatment of DMBA-induced breast cancer in animal model, inducing a reduction in oxidative stress and chemotherapy toxicity, meaning that ACE may have clinical implication in further studies.

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“…Although the molecular mechanisms of neurotoxicity induced by chemotherapy have not yet been fully elucidated, studies have shown an increased reactive oxygen species (ROS) production and increased lipid peroxidation in the brain tissue of rats exposed to VCR. Thus indicating an association between chemotherapy and increased oxidative stress, which may lead to a reduction of the viability of the neurons [6,7]. In this sense, therapies that positively modulate the antioxidant system may be important tools in the treatment of various diseases and toxicities that affect nerve system.…”

Section: Introductionmentioning

confidence: 99%

O exercício físico protege o equilíbrio dinâmico e coordenação motora de ratos tratados com vincristina

Sagrillo

Zorzi

Royes

et al. 2021

Rev Bras Fisiol Exerc

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Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

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Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate

Cited by 8 publications

References 29 publications

The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model

O exercício físico protege o equilíbrio dinâmico e coordenação motora de ratos tratados com vincristina

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