Prognostic significance of histologic host response in cancer of the large bowel

Nacopoulou, L.; Azaris, P.; Papacharalampous, N; Davaris, Panagiotis

doi:10.1002/1097-0142(19810301)47:5<930::aid-cncr2820470519>3.0.co;2-1

Cited by 54 publications

(17 citation statements)

References 27 publications

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“…Patients with histologic evidence of a more vigorous immune response experience improved outcomes 37,38 . Similarly, patients with a depleted or under-stimulated lymphocytic response to their crc, either within their lymphatics 39 or at the tumour edge 40 , have a relatively unfavourable prognosis. Galon et al 41 coined the term "immune contexture" to describe the effect of the local host immune reaction in crc.…”

Section: Discussionmentioning

confidence: 67%

Lymph Node Evaluation for Colon Cancer in Routine Clinical Practice: A Population-Based Study

et al. 2017

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Section: Discussionmentioning

confidence: 67%

Lymph Node Evaluation for Colon Cancer in Routine Clinical Practice: A Population-Based Study

et al. 2017

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“…They studied that majority of well and moderately differentiated tumors were of stage II, whereas maximum proportion of poorly differentiated tumors had stage III. Similarly Ueno et al, Nacopoulou et al and Vasile et al [13,38,39] also confirmed the poor survival of high-grade tumors. Spratt et al [21] evaluated that survival of patients with colorectal carcinoma is related to lymphocytic response, as more the lymphocytic response better is the survival of patient.…”

Section: Resultsmentioning

confidence: 99%

“…Spratt et al [21] evaluated that survival of patients with colorectal carcinoma is related to lymphocytic response, as more the lymphocytic response better is the survival of patient. Also Nacopoulou et al [38] stated that the patients with tumors associated with lymphocytic response at the advancing edges have better survival as compared to the tumors lacking it. So as the intensity of associated lymphocytic response increases, better will be its prognosis.…”

Section: Resultsmentioning

confidence: 99%

Colorectal Cancer in India: An Iceberg Analysis From North India

Narang¹,

Puri²,

Singh³

et al. 2016

jemds

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Colon and rectal cancers share many environmental risk factors and are both found in individuals with specific genetic syndromes. Carcinomas are rare before the age of 40 years except in individuals with genetic predisposition or predisposing conditions such as chronic inflammatory bowel disease. The incidence is increasing in Indian scenario, therefore there is need to study the disease behaviour, presentations and prognostic factors. AIMSTo analyse various histological parameters of colorectal carcinoma and to correlate these parameters with each other and with Ki-67 wherever available. MATERIAL AND METHODSA total of 200 colectomy done for colorectal carcinoma and received in the Department of Pathology, Dayanand Medical College and Hospital during 4-year period were analysed with reference to Histological subtype, grade, stage and correlated these parameters and with Ki-67 wherever available. RESULTSMean age of presentation of patients with colon carcinoma was 54.2±14.2years with male female ratio being 1.8:1. Rectosigmoid colon was the commonest site of tumor followed by caecum. Adenocarcinoma NOS with moderate differentiation was the commonest histological subtype. Most common T, N and M stage of presentation was T3, N0 and M0 respectively. Features associated with higher stage were young age, male sex, left sided tumors, signet ring cell & mucinous subtypes, higher grade, infiltrative tumor margins, no lymphocytic response at the advancing edges. MIB 1 labelling index was higher in Stage II patients. CONCLUSIONColorectal carcinomas are less common in Indian population however the incidence is increasing. Therefore the pathologist and clinicians must be aware of precursor lesions and prognostic factors to diagnose and treat the colorectal carcinomas at early stage.

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“…The observation that a severe intratumoral inflammatory reaction, mostly lymphocytic and eosinophilic infiltration, is associated with a better survival in colorectal cancer has also been reported by others (Watt and House, 1978;Nacopoulou et al, 1981;Pretlow et al, 1983;Ponz de Leon et al, 1992). The inflammatory response within these malignancies could be considered as an attempt of the host to enclose the carcinomatous tissue and to destroy cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer

Ganesh

Sier²,

Heerding³

et al. 1997

Br J Cancer

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Summary Despite the advances in pre-, peri-and post-operative medical care of colorectal carcinoma patients, the prognosis has improved only marginally over recent decades. Thus, additional prognostic indicators would be of great clinical value to select patients for adjuvant therapy. In previous studies we found that colorectal carcinomas have a marked increase of the urokinase-type of plasminogen activator (u-PA), and the inhibitors PAI-1 and PAI-2, whereas the tissue-type plasminogen activator (t-PA) is found to be decreased in comparison with adjacent normal mucosa. In the present study we evaluated the prognostic value of several plasminogen activation parameters, determined in both normal and carcinomatous tissue from colorectal resection specimens, for overall survival of 136 Dukes' stage B and C colorectal cancer patients, in relation to major clinicopathological parameters. Uni-and multivariate analyses indicated that a high PAI-2 antigen level in carcinoma, a low t-PA activity and antigen level and a high u-PA/t-PA antigen ratio in adjacent normal mucosa are significantly associated with a poor overall survival. A high ratio of u-PA antigen in the carcinomas and t-PA antigen in normal mucosa, i.e. u-PA(C)/t-PA(N), was found to be predictive of a poor overall survival as well. All these parameters were found to be prognostically independent of the clinicopathological parameters. Multivariate analysis of combinations of these prognostically significant plasminogen activation parameters revealed that they are important independent prognostic indicators and have in fact a better prognostic value than their separate components. Based on these combined parameters, subgroups of patients with Dukes' stage B and C colorectal cancer could be identified as having either a high or a low risk regarding overall survival. In conclusion, these findings emphasize the relevance of the intestinal plasminogen activation system for survival prognosis of patients with colorectal cancer and, in the future, might constitute a patient selection criterion for adjuvant therapy.

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Prognostic significance of histologic host response in cancer of the large bowel

Cited by 54 publications

References 27 publications

Lymph Node Evaluation for Colon Cancer in Routine Clinical Practice: A Population-Based Study

Lymph Node Evaluation for Colon Cancer in Routine Clinical Practice: A Population-Based Study

Colorectal Cancer in India: An Iceberg Analysis From North India

Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer

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