Prognostic significance of clinical-anthropometric, biochemical, metabolic, vascular-inflammatory and molecular-genetic markers in the development of the first ischemic stroke

Шишкова, В Н; Адашева, Т. В.; Remenik, A. Yu.; Valyaeva, V.; Shklovsky, V. M.

doi:10.17116/jnevro2018118214-11

Cited by 13 publications

(4 citation statements)

References 13 publications

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“…e activation of DOR is neuroprotective against cerebral I/R injury through various mechanisms, including maintaining ionic homeostasis against excitotoxic and antioxidative stress [8,9]. Recently, a large amount of research suggests that the alleviation of inflammatory response, such as downregulation of the expression of proinflammatory mediators TNF-α, IL-6, and IL-1β and upregulation of anti-inflammatory factors IL-4 and IL-10 [10][11][12], is also involved in the neuroprotection after cerebral I/R. e binding of brain-derived neurotrophic factor (BDNF) to its high affinity receptor tropomyosin-related kinase B (TrkB) has been recognized as one of the anti-inflammatory pathways [13,14].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Ameliorates Cerebral I/R‐Induced Inflammation through DOR‐BDNF/TrkB Pathway

Geng

Chen

Sun

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The beneficial effects of electroacupuncture (EA) at Shuigou (GV26) and Neiguan (PC6) on poststroke rehabilitation are critically related to the activation of the delta-opioid receptor (DOR). The underlying anti-inflammatory mechanisms in DOR activation and EA-mediated neuroprotection in cerebral ischemia/reperfusion (I/R) injury were investigated in the current study. Cell proliferation and apoptosis were detected by morphological changes, cell counting kit-8 (CCK-8) assay, lactate dehydrogenase (LDH) release, and TUNEL staining. The mRNA levels were evaluated by using real-time quantitative polymerase chain reaction (RT-qPCR), and the protein expression was measured by western blot or enzyme-linked immunosorbent assay (ELISA) in vitro. Infarct volume was examined by cresyl violet (CV) staining, neurologic recovery was assessed by neurological deficit scores, and pro- and anti-inflammatory cytokines were determined by immunofluorescence in vivo. DOR activation greatly ameliorated morphological injury, reduced LDH leakage and apoptosis, and increased cell viability. It reversed the oxygen-glucose deprivation/reoxygenation- (OGD/R-) induced downregulation of DOR mRNA and protein, as well as BDNF protein. DOR activation also reduced proinflammatory cytokine gene expression, including TNF-α, IL-1β, and IL-6, and at the same time, increased anti-inflammatory cytokines IL-4 and IL-10 in OGD/R challenged PC12 cells. EA significantly reduced middle cerebral artery occlusion/reperfusion- (MCAO/R-) induced infarct volume and attenuated neurologic deficit scores. It markedly increased the expression of IL-10 and decreased IL-1β, while sham EA did not have any protective effect in MCAO/R-injured rats. DOR activation plays an important role in neuroprotection against OGD/R injury by inhibiting inflammation via the brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) pathway. The neuroprotective efficacy of EA at Shuigou (GV26) and Neiguan (PC6) on cerebral I/R injury may be also related to the inhibition of inflammatory response through the DOR-BDNF/TrkB pathway.

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Section: Introductionmentioning

confidence: 99%

Electroacupuncture Ameliorates Cerebral I/R‐Induced Inflammation through DOR‐BDNF/TrkB Pathway

Geng

Chen

Sun

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Strictly following the inclusion criteria, 47 properly controlled full-length studies, including 23 rs1800629 genotype-related studies ( Um et al, 2003 ; Balding et al, 2004 ; Lee et al, 2004 ; Um and Kim, 2004 ; Karahan et al, 2005 ; Rubattu et al, 2005 ; Harcos et al, 2006 ; Lalouschek et al, 2006 ; Llamas Sillero et al, 2007 ; Banerjee et al, 2008 ; Shi et al, 2009 ; Kim et al, 2010 ; Tong et al, 2010 ; Sultana et al, 2011 ; Cui et al, 2012 ; Tuttolomondo et al, 2012 ; Zhao et al, 2012 ; Djordjevic et al, 2013 ; Wawrzynek et al, 2014 ; Gu et al, 2015 ; Kumar et al, 2016 ; Palm et al, 2020 ; Kamdee et al, 2021 ) and 13 case reports ( Zaremba and Losy, 2001a , b ; Intiso et al, 2004 ; Domac et al, 2007 ; Jefferis et al, 2009 ; Cure et al, 2013 ; Bokhari et al, 2014 ; de Sousa Parreira et al, 2015 ; Wytrykowska et al, 2016 ; Billinger et al, 2017 ; Shishkova et al, 2018 ; Zhang Y. Y. et al, 2018 ; Ma et al, 2020 ) on the circulating level of TNF-α were finally selected for the meta-analysis ( Figure 1 ). Genotype-related literature included a total of 9,120 patients and 9,249 healthy controls (Caucasian, n = 10; Asian, n = 15).…”

Section: Resultsmentioning

confidence: 99%

TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke—An Updated Meta-Analysis

Duan

Wang

Shang

et al. 2022

Front. Aging Neurosci.

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ObjectiveAccumulated studies have explored gene polymorphisms and circulating levels of tumor necrosis factor (TNF)-α and insulin-like growth factor (IGF)-1 in the etiology of ischemic stroke (IS). Of the numerous etiopathological factors for IS, a single-nucleotide polymorphism (SNP) rs1800629 located in the TNF-α gene promoter region and increased levels of TNF-α were found to be associated with IS in different ethnic backgrounds. However, the published results are inconsistent and inconclusive. The primary objective of this meta-analysis was to investigate the concordance between rs1800629 polymorphism and IS. A secondary aim was to explore circulating levels of TNF-α and IGF-1 with IS in different ethnic backgrounds and different sourced specimens.MethodsIn this study, we examined whether rs1800629 genetic variant and levels of TNF-α and IGF-1 were related to the etiology of IS by performing a meta-analysis. Relevant case-control studies were retrieved by database searching and systematically selected according to established inclusion criteria.ResultsA total of 47 articles were identified that explored the relationship between the rs1800629 polymorphism and levels of TNF-α and IGF-1 with IS risk susceptibility. Statistical analyses revealed a significant association between the rs1800629 polymorphism and levels of TNF-α and IGF-1 with IS pathogenesis.ConclusionOur findings demonstrated that the TNF-α rs1800629 polymorphism, the increased levels of TNF-α, and decreased levels of IGF-1 were involved in the etiology of IS.

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“…The correlation between blood lipids and stroke outcome varies depending on the components of blood lipids. CHOL is an adjustable risk factor, and some scholars believe that CHOL level is closely associated with the onset of first ischemic stroke (31). Globally, high cholesterol levels (>185 mg/dL) were associated with a 24% increase in strokerelated disability-adjusted life years from 1990 to 2013 (32).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for acute ischemic stroke following intravenous thrombolysis: a 2-center retrospective cohort study

Liu¹,

Wang²

2022

Ann Palliat Med

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Background:The risk factors associated with in-hospital poor neurological function after intravenous thrombolysis in patients with acute ischemic stroke (AIS) is of major public health interest. The aim of the present study was to screen for risk factors associated with in-hospital poor neurological function after intravenous thrombolysis in patients with acute AIS.Methods: This was a population-based cohort study. A total of 878 AIS patients who were admitted to advanced stroke centers of 2 Grade A tertiary hospitals in China between January 2018 and January 2020, and who had undergone intravenous thrombolysis therapy, were included in the present study. Baseline and treatment data of participant were collected. Poor neurological function was defined as National Institutes of Health Stroke Scale (NIHSS) score ≥16 on day 7 after onset, indicating stroke severity. Univariable and multivariable analyses were used to screen out factors associated with the endpoint.

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Prognostic significance of clinical-anthropometric, biochemical, metabolic, vascular-inflammatory and molecular-genetic markers in the development of the first ischemic stroke

Abstract: Based on the data obtained in this study, a probability model for the development of the first ischemic stroke was obtained. Of all the parameters studied, diabetes mellitus, adiponectin, Apo A1, IL-4 made the largest contribution to the probability of the first ischemic stroke.

Cited by 13 publications

References 13 publications

Electroacupuncture Ameliorates Cerebral I/R‐Induced Inflammation through DOR‐BDNF/TrkB Pathway

Electroacupuncture Ameliorates Cerebral I/R‐Induced Inflammation through DOR‐BDNF/TrkB Pathway

TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke—An Updated Meta-Analysis

Risk factors for acute ischemic stroke following intravenous thrombolysis: a 2-center retrospective cohort study

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