TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke—An Updated Meta-Analysis

Abstract

ObjectiveAccumulated studies have explored gene polymorphisms and circulating levels of tumor necrosis factor (TNF)-α and insulin-like growth factor (IGF)-1 in the etiology of ischemic stroke (IS). Of the numerous etiopathological factors for IS, a single-nucleotide polymorphism (SNP) rs1800629 located in the TNF-α gene promoter region and increased levels of TNF-α were found to be associated with IS in different ethnic backgrounds. However, the published results are inconsistent and inconclusive. The primary objective of this meta-analysis was to investigate the concordance between rs1800629 polymorphism and IS. A secondary aim was to explore circulating levels of TNF-α and IGF-1 with IS in different ethnic backgrounds and different sourced specimens.MethodsIn this study, we examined whether rs1800629 genetic variant and levels of TNF-α and IGF-1 were related to the etiology of IS by performing a meta-analysis. Relevant case-control studies were retrieved by database searching and systematically selected according to established inclusion criteria.ResultsA total of 47 articles were identified that explored the relationship between the rs1800629 polymorphism and levels of TNF-α and IGF-1 with IS risk susceptibility. Statistical analyses revealed a significant association between the rs1800629 polymorphism and levels of TNF-α and IGF-1 with IS pathogenesis.ConclusionOur findings demonstrated that the TNF-α rs1800629 polymorphism, the increased levels of TNF-α, and decreased levels of IGF-1 were involved in the etiology of IS.

The Association between Systemic Immune-Inflammation Index and All-Cause Mortality in Acute Ischemic Stroke Patients: Analysis from the MIMIC-IV Database

“…The optimal time point needs to be explored. Second, our study lacked some information at the time of participants' blood sample collection, including indicators of the acute inflammatory state (i.e., CRP, IL-1, IL-6, and TNF- α ) [ 29 – 31 ], some other drugs use such as the use of steroids and nonsteroidal anti-inflammatory drugs, previous use of antibiotics and therapy durations, and information about other diseases that could cause inflammation, such as pneumonia, all of which may influence baseline leukocyte counts. Finally, as a single-center retrospective study, selection bias was inevitable; therefore, prospective studies are needed to confirm this finding.…”

Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review

“…In accordance, a recent meta‐analysis confirmed a link between TNF‐α polymorphism as well as circulating TNF‐α levels with ischemic stroke. 15 Although this finding seems plausible in light of the overwhelming evidence on inflammation and atherosclerosis, 16 further confirmatory studies are certainly needed before clinical relevance can be considered in regard to diagnosis of ischemic stroke causes.…”

Network Pharmacology-based Analysis of the Effects of Huangqi Guizhi Wuwu Decoction on Ischemic Stroke*

“…In the past few years, tumor necrosis factor-α (TNF-α) has become a potential marker of stroke due to its essential role in stroke (Xue et al, 2022). Duan et al (2022) found that the increase in TNF-α level was related to the etiology of ischemic stroke, and TNF-α level was significantly correlated with the pathogenesis of ischemic stroke. All the above studies indicated that the therapeutic effect of quercetin, kaempferol, β-sitosterol, and the critical components of HGWD might be reflected in inflammationrelated signaling pathways and targets, which can effectively inhibit inflammation and play a role in the treatment of ischemic stroke.…”