Prognostic significance of admission levels of cardiac indicators in patients with acute ischaemic stroke: Prospective observational study

Li, Xuan; Chen, Xiangjun; Wang, Hairong; Pan, Shuming

doi:10.1177/0300060514549217

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Stroke in patients with heart failure is associated with more severe neurological deficits and very high rates of cardiovascular morbidity and mortality (Hays 2006;Vemmos 2012). In addition, the association between myoglobin, aortic stiffness, CK-MB, ejection fraction (EF) and adverse outcomes in stroke patients has been widely reported (Liu et al 2014;Rojek 2016). The clinical manifestations of cardiac damage after stroke and its impact on the patient's prognosis have been a hot topic of discussion.…”

Section: Introductionmentioning

confidence: 99%

Cardiac parameters affect prognosis in patients with non-large atherosclerotic infarction

Zeng

Zhang

Cheng

et al. 2021

Mol Med

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Background Although large artery atherosclerosis (LAA) is the most common type of cerebral infarction, non-LAA is not uncommon. The purpose of this paper is to investigate the prognosis of patients with non-LAA and to establish a corresponding nomogram. Patients and methods Between June 2016 and June 2017, we had 1101 admissions for acute ischemic stroke (AIS). Of these, 848 were LAA and 253 were non-LAA. Patients were followed up every 3 months with a minimum of 1 year of follow-up. After excluding patients who were lost follow-up and patients who did not meet the inclusion criteria, a total of 152 non-LAA patients were included in this cohort study. After single-factor analysis and multifactor logistic regression analysis, the risk factors associated with prognosis were derived and different nomograms were developed based on these risk factors. After comparison, the best model is derived. Results Logistics regression found that the patient’s National Institutes of Health Stroke Scale (NIHSS) score, ejection fraction (EF), creatine kinase-MB (CK-MB), age, neutrophil-to-lymphocyte ratio (NLR), aspartate aminotransferase (AST), and serum albumin were independently related to the patient’s prognosis. We thus developed three models: model 1: single NIHSS score, AUC = 0.8534; model 2, NIHSS + cardiac parameters (CK-MB, EF), AUC = 0.9325; model 3, NIHSS + CK−MB + EF + age + AST + NLR + albumin, AUC = 0.9598. We compare the three models: model 1 vs model 2, z = − 2.85, p = 0.004; model 2 vs model 3, z = − 1.58, p = 0.122. Therefore, model 2 is considered to be the accurate and convenient model. Conclusions Predicting the prognosis of patients with non-LAA is important, and our nomogram, built on the NIHSS and cardiac parameters, can predict the prognosis accurately and provide a powerful reference for clinical decision making.

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Section: Introductionmentioning

confidence: 99%

Cardiac parameters affect prognosis in patients with non-large atherosclerotic infarction

Zeng

Zhang

Cheng

et al. 2021

Mol Med

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“…Another similar study was performed in China by Liu et al 18 regarding the short-term prognostic value of cardiac indicators in patients who had experienced acute ischemic stroke. They studied various cardiac biomarkers and concluded that myoglobin may be an independent predictor of short-term outcomes in patients with acute ischemic stroke.…”

Section: Discussionmentioning

confidence: 73%

“…14 stroke severity was assessed via National Institutes of Health Stroke Scale (NIHSS). The following classes were made based on NIHSS scores Mild<5, Mild to Moderately severe, severe [15][16][17][18][19][20][21][22][23][24] and very severe >25.15 Subjects and their caregivers were provided with a detailed description of the study and were inducted into the study after written informed consent. Subjects with confounding variables like the presence of cardiac illness or skeletal conditions were identified by detailed history taking and excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Rise CKMB and Myoglobin Levels in Non-Cardiac Patients of Ischemic Stroke Presenting to Emergency Department of a Tertiary Care Hospital

Dawood

Abbas

Hashmat

et al. 2022

PAFMJ

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Objective: To assess the rise in CKMB and Myoglobin levels and associated factors in non-cardiac patients of ischemic stroke presenting to the Emergency Department of a Tertiary Care Hospital. Study Design: Cross-sectional study. Place and Duration of Study: Department of Emergency Medicine, Pak Emirates Military Hospital (PEMH), Rawalpindi Pakistan, from Dec 2020 to May 2021. Methodology: A total of 150 patients with ischemic stroke diagnosed by the consultant Emergency physician or medical specialist based on clinical and neuro-radiological findings were included in this study. Serum CKMB and myoglobin levels were assessed along with other baseline investigations among the study participants. In addition, the relationship of age, gender, the severity of the stroke and the presence of non-cardiac comorbidities was assessed with the rise in CKMB and myoglobin levels among the target population. Results: Out of 200 patients with ischemic stroke included in the study, 114(67.0%) were males, while 86(43.0%) were females. 75(37.5%) patients had either raised CKMB or Myoglobin levels, while 125(62.5%) patients had both biomarkers within range. On the National Institutes of Health Stroke Scale, 110(55.0%) patients had mild, 55(22.5%) had mild to moderately severe, 25(12.5%) had severe, and 10(5.0%) had very severe symptoms. Statistical analysis revealed that increased stroke severity had a statistically significant relationship (p-value<0.001) with raised CKMB/Myoglobin levels in the target population. Conclusion: Raised CKMB or myoglobin levels were found in many patients with acute ischemic stroke. The stroke severity was associated with raised levels of these biomarkers.

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“…Cardiometabolic disturbance has been associated with early mortality and a poor prognosis in patients with stroke ( 28 , 29 ). A study identified several cardiac complications after 2 days of intracerebral hemorrhage and 3 months of ischemic stroke ( 6 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study

Zhang

Alsamani²,

Wu³

et al. 2022

Front. Neurol.

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Background and aimsCardiac enzymes are recognized as a valuable tool for predicting the prognosis of various cardiovascular diseases. The prognostic value of alpha-hydroxybutyrate dehydrogenase (α-HBDH) in patients with intracerebral hemorrhage (ICH) was ambiguous and not evaluated.MethodsTwo hundred and thirteen Chinese patients with ICH participated in the study from December 2018 to December 2019. Laboratory routine tests and cardiac enzymes, including α-HBDH level, were examined and analyzed. All the patients were classified into two groups by the median value of α-HBDH: B1 <175.90 and B2 ≥175.90 U/L. The clinical outcomes included functional outcome (according to modified Rankin Scale (mRS) score ≥3), all-cause death, and recurrent cerebro-cardiovascular events 1 year after discharge. Associations between the α-HBDH and the outcomes were evaluated using logistic regression analysis. Univariate survival analysis was performed by the Kaplan–Meier method and log-rank test.ResultsOf the 213 patients, 117 had α-HBDH ≥175.90 U/L. Eighty-two patients had poor functional outcomes (mRS≥3). During the 1-year follow-up, a total of 20 patients died, and 15 of them had α-HBDH ≥175.90 U/L during the follow-up time. Moreover, 24 recurrent events were recorded. After adjusting confounding factors, α-HBDH (≥175.90) remained an indicator of poor outcome (mRS 3-6), all-cause death, and recurrent cerebro-cardiovascular events. The ORs for B2 vs. B1 were 4.78 (95% CI: 2.60 to 8.78, P = 0.001), 2.63 (95% CI: 0.80 to 8.59, P = 0.11), and 2.40 (95% CI: 0.82 to 7.02, P = 0.11) for poor functional outcomes with mRS ≥ 3, all-cause death, and recurrent cerebro-cardiovascular events, respectively.ConclusionIncreased α-HBDH at admission was independently related to poor functional outcome and all-cause mortality in patients with ICH at 1-year follow-up.

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Prognostic significance of admission levels of cardiac indicators in patients with acute ischaemic stroke: Prospective observational study

Cited by 9 publications

References 28 publications

Cardiac parameters affect prognosis in patients with non-large atherosclerotic infarction

Cardiac parameters affect prognosis in patients with non-large atherosclerotic infarction

Rise CKMB and Myoglobin Levels in Non-Cardiac Patients of Ischemic Stroke Presenting to Emergency Department of a Tertiary Care Hospital

The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study

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