Non-toxic nanomaterials have gained significant importance recently in the treatment of industrial wastewater that sometimes contains organic dyes such as methylene blue.
We
reported the fabrication of an electrochemical sensor for uric
acid (UA) monitoring using metal-free electrode based on heteroatoms
(S, N, P, and O) doped carbon (HADC) nanoparticles, derived from polyphosphazene,
synthesized via precipitation polymerization reaction between hexachlorocyclotriphosphazene
(HCCP) and 1,4-dithiane-2,5-diol (DD) under sonication irradiations
at 40 °C, following its modification with benzimidazolium-1-acetate
ionic liquid (BIL). The developed HADC-BIL electrode showed a highly
sensitive and selective response toward UA even in the presence of
highly electroactive interferences such as ascorbic acid (AA), dopamine
(DA), glucose (Glu), and hydrogen peroxide (H2O2). Our results demonstrated that the as-fabricated HADC-BIL electrode
allows us to detect UA over a linear range of 2–1050 μM
with a detection limit of 1.27 μM. Further, we were able to
monitor the amount of UA level in the blood of a gout patient using
the developed HADC-BIL electrode, which ensures the effectiveness
of the developed sensor for the sensitive and selective detection
of UA from real samples.
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