The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study

Abstract

Background and aimsCardiac enzymes are recognized as a valuable tool for predicting the prognosis of various cardiovascular diseases. The prognostic value of alpha-hydroxybutyrate dehydrogenase (α-HBDH) in patients with intracerebral hemorrhage (ICH) was ambiguous and not evaluated.MethodsTwo hundred and thirteen Chinese patients with ICH participated in the study from December 2018 to December 2019. Laboratory routine tests and cardiac enzymes, including α-HBDH level, were examined and analyzed. All the patients were classified into two groups by the median value of α-HBDH: B1 <175.90 and B2 ≥175.90 U/L. The clinical outcomes included functional outcome (according to modified Rankin Scale (mRS) score ≥3), all-cause death, and recurrent cerebro-cardiovascular events 1 year after discharge. Associations between the α-HBDH and the outcomes were evaluated using logistic regression analysis. Univariate survival analysis was performed by the Kaplan–Meier method and log-rank test.ResultsOf the 213 patients, 117 had α-HBDH ≥175.90 U/L. Eighty-two patients had poor functional outcomes (mRS≥3). During the 1-year follow-up, a total of 20 patients died, and 15 of them had α-HBDH ≥175.90 U/L during the follow-up time. Moreover, 24 recurrent events were recorded. After adjusting confounding factors, α-HBDH (≥175.90) remained an indicator of poor outcome (mRS 3-6), all-cause death, and recurrent cerebro-cardiovascular events. The ORs for B2 vs. B1 were 4.78 (95% CI: 2.60 to 8.78, P = 0.001), 2.63 (95% CI: 0.80 to 8.59, P = 0.11), and 2.40 (95% CI: 0.82 to 7.02, P = 0.11) for poor functional outcomes with mRS ≥ 3, all-cause death, and recurrent cerebro-cardiovascular events, respectively.ConclusionIncreased α-HBDH at admission was independently related to poor functional outcome and all-cause mortality in patients with ICH at 1-year follow-up.

Causal associations of gut microbiota and metabolites on sepsis: a two-sample Mendelian randomization study

“…Additionally, our research has identified α-hydroxybutyrate as closely intertwined with sepsis, qualifying it as a risk determinant for sepsis and the subsequent 28-day mortality rate. Historical studies have attested to the association of α-hydroxybutyrate with a gamut of ailments including diabetes, insulin resistance, obesity, and heart failure ( 27 , 28 ). In certain contexts, it is perceived as a nascent biomarker for hypoxia and/or mitochondrial dysfunction ( 29 ).…”

“…The mechanisms through which Coprococcus potentially influences sepsis could encompass several facets. Historically, studies have posited that Coprococcus can modulate the production of cytokines IL-1b and IL-6, thereby orchestrating the inflammatory response during an infection (26). Concurrently, Coprococcus is recognized as one of the principal bacteria responsible for butyrate production; butyrate, deemed a salubrious short-chain fatty acid, is pivotal for the health and functionality of colonic epithelial cells (16).…”

Diagnosis potential of subarachnoid hemorrhage using miRNA signatures isolated from plasma-derived extracellular vesicles

“…Neurological outcomes were evaluated by the modified Rankin Scale (mRS) at one year post-aSAH using outpatient outcomes. At the end of the follow-up period, patients with mRS scores of 0-2 were considered to have good outcomes, and those with mRS scores of 3-6 were considered to have poor outcomes (Limin et al, 2022). was collected within 24 h of admission, and each sample was obtained in the fasted state.…”

Research advances in predicting the expansion of hypertensive intracerebral hemorrhage based on CT images: an overview

“…Conversely, any intervention that reduces hematoma growth by 2 to 4 ml is equivalent to a 10% to 20% reduction in the risk of death or dependency within 90 days ( Chu et al, 2022 ; Delcourt et al, 2012 ). In clinical practice, accurately predicting the risk of HE is helpful for early targeted treatment or surgery ( Al-Shahi Salman et al, 2018 ), which can prevent adverse events, reduce patient mortality and disability rates, and have important clinical significance ( Limin et al, 2022 ).…”