Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma

Paz, Dante De; Young, Chi-Kuang; Chien, Huei-Tzu; Tsao, Chung-Kang; Fok, Cheong Chon; Fan, Kang‐Hsing; Liao, Chun‐Ta; Wang, Hung‐Ming; Kang, Chung‐Jan; Chang, Joseph Tung-Chieh; Huang, Shyh‐Chin

doi:10.21873/anticanres.13313

Cited by 25 publications

(17 citation statements)

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“…When analyzing our overall data, we observed an association between good prognosis and HPV positivity, whereas adverse prognosis was associated with increasing both CRP levels and WBC counts. These are expected associations that have been described in previous studies [ 9 , 21 , 22 , 23 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 78 ] and therefore suggest that our patient cohort is representative. Furthermore, histopathological features like tumor lymphocyte density predict prognosis both in HPV-negative and HPV-positive oropharyngeal cancer patients [ 79 ].…”

Section: Discussionsupporting

confidence: 85%

“…Several previous studies have shown that both increased systemic CRP levels [ 8 , 47 , 48 , 49 , 50 , 51 , 52 ] and IL6 levels [ 9 , 21 , 22 , 23 , 53 , 54 , 55 , 56 , 57 ] are associated with an adverse prognosis in HNSCC. IL6 can function as a driver of the acute phase reaction, i.e., increased CRP levels can at least partly be due to an IL6 effect [ 1 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic inflammatory responses, including the systemic levels of acute phase cytokines, have a prognostic impact in several cancers, including HNSCC [ 9 , 10 , 21 , 22 , 23 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. However, the acute phase reaction is an example of how several cytokines (including IL6 family and IL1 subfamily members as well as TNFα) form an interacting network [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

et al. 2020

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C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

et al. 2020

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“…Over-expressed CRP involves various tumors, including lung, lymphoma, ovary, and multiple myeloma. [5][6][7][8] CRP is a prototypic acute-phase protein secreted by the liver into the blood. Usually, CRP is <2 mg/L in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis

Chen

Cong

et al. 2020

Cancer Medicine

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“…Clinically, detection of tumor markers in the serum is easy and non-invasive. Squamous cell carcinoma antigen (SCC-Ag), cytokeratin, are well-known tumor-related markers [6]. We assumed that protein markers produced by the tumor can be reduced by tumor ablative surgery.…”

Section: Introductionmentioning

confidence: 99%

Changes in oncogenic protein levels in peri-implant oral malignancy: a case report

Seo

Myoung

Lee

et al. 2019

Maxillofac Plast Reconstr Surg

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BackgroundOral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors.Case presentationA 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient’s preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC).ConclusionsThe protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met, HER2, and ERb were significantly lower in the serum collected on postoperative day 10 than in the preoperative serum, and if these proteins are consistently not elevated in the serum 3 months after surgery compared with the preoperative serum, these proteins can be potential oncogenic proteins. However, we also found that the serum extracted 3 months after the operation had elevated levels of oncogenic proteins compared with that of the preoperative and 10-day postoperative serum indicating the possibility of tumor recurrence. At postoperative follow-up period, ipsilateral neck metastasis and second primary lesion were found and additional surgery was performed to the patient. IP-HPLC using the patient’s serum shows the possibility of oncogenic protein detection. However, follow-up IP-HPLC data is needed to find out patient-specific prognostic factors.

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Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma

Cited by 25 publications

References 0 publications

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis

Changes in oncogenic protein levels in peri-implant oral malignancy: a case report

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