The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis

Chen, Yanglan; Cong, Rong; Ji, Chengjian; Ruan, Wen-hua

doi:10.1002/cam4.3520

Cited by 19 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some routinely measured laboratory analyte baselines have been shown to have prognostic importance in malignant diseases. Both prospective and retrospective studies and also meta-analyses have described the poor prognostic role of elevated baseline C-reactive protein (CRP) (1)(2)(3)(4), crosslinked fibrin degradation products (D-dimer) (5)(6)(7)(8), lactate dehydrogenase (LDH) (9)(10)(11)(12), and decreased albumin (13)(14)(15) in cancer. Deme and Telekes have also reviewed the value of elevated CRP (16), D-dimer (17), LDH (18), and decreased albumin (19) for poor outcomes of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination

Deme¹,

Kovács

Telekes³

2022

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Introduction: Consistent association between elevated baseline serum values and C-reactive protein (CRP), cross-linked fibrin degradation products (D-dimer), lactate dehydrogenase (LDH), decreased baseline serum albumin, absolute lymphocyte count to absolute monocyte count ratio (LMR), elevated absolute neutrophil count to absolute lymphocyte count ratio (NLR), elevated platelet count to absolute lymphocyte count ratio (PLR), and between some combinations of these biomarkers and the short overall survival of patients with malignant diseases has already been reported. These biomarkers are independent prognostic factors for cancer. Here, the most significant biomarker combination of these values was searched and studied in real-life advanced cancer patients of a single center.Methods: The authors retrospectively analyzed the association of the aforementioned biomarkers and their combination and OS of 75 consecutive cancer patients with locally advanced, recurrent, or metastatic diseases. Validated cut-off determination was used.Results: CRP, albumin, and PLR showed marked association with OS. Cut-off values for significant shorter OS were 30.65 mg/L (p < 0.001), 44.35 g/L (p < 0.001), and 168.20 (p < 0.001), respectively. Based on assessed biomarker cut-offs, four patient groups were created to determine whether biomarker values were out of range (ORV) compared to cut-off: 1) No ORV biomarkers (n = 24; OS = 26.07 months); 2) one ORV biomarker (n = 21; OS = 13.50 months); 3) two ORV biomarkers (n = 20; OS = 7.97 months), and 4) three ORV biomarkers (n = 10; OS = 3.91 months). Significant differences in OS were detected between the groups: For 1. vs. 2. hazard ratio (HR) = 3.0 (95% CI: 1.5–6.2), p = 0.003; for 1. vs. 3. HR = 4.1 (95% CI: 2.0–8.3), p < 0.001; and for 1. vs. 4. HR = 10.2 (95% CI: 4.2–24.6), p < 0.001.Conclusion: Based on our analysis, we can confirm that the complex monitoring of CRP, albumin, and PLR would provide a good estimation of OS. Large scale prospective studies are warranted to explore this and other useful combinations of prognostic biomarkers and their relationship to the well-established prognostic systems in real-life.

show abstract

Section: Introductionmentioning

confidence: 99%

Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination

Deme¹,

Kovács

Telekes³

2022

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…CRP, an acute-phase inflammatory protein, is synthesized in the liver in response to inflammation. Many studies have demonstrated that CRP was associated with cancer survival (36,(40)(41)(42)(43)(44)(45). In addition, the production of CRP in the liver is stimulated by IL-6 (46).…”

Section: Discussionmentioning

confidence: 99%

“…Due to the discrepancies in the results of the studies outlined ( Supplementary Table 1 ) above, Chen et al conducted a meta-analysis and reported that an elevated pretreatment CRP level is an indicator of poor prognosis in HNSCC ( 36 ). To date, no Chinese studies have investigated the effects of serum CRP level on the prognosis of patients with HNSCC, including cancers of the hypopharynx, nasopharynx, larynx, and oropharynx.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

Zhang

2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThis study evaluated the association of pretreatment serum C-reactive protein (CRP) level with prognosis in patients with head and neck squamous cell carcinoma (HNSCC).MethodsWithin a single-center retrospective study, HNSCC patients receiving treatment between 2014 and 2016 were analyzed regarding the prognostic value of CRP serum levels. X-Tile software was used to determine the optimal cutoff value of serum CRP level. The log-rank test and Kaplan–Meier method were used to assess the effects of CRP level on prognosis in patients with HNSCC. Univariate and multivariate analyses (enter method) using a Cox proportional hazards model were utilized to identify prognostic indicators of progression-free survival (PFS) as the primary outcome and overall survival (OS) as the secondary outcome.ResultsA total of 221 patients with HNSCC were assessed for eligibility, and 208 cases were included in the analysis. The HNSCC patients in the low-group (CRP ≤11.3 mg/L) showed better survival than those in the high-group (CRP > 11.3 mg/L). The univariate and multivariate analyses showed that N1-3 stage and a high serum CRP level (>11.3 mg/L) were unfavorable prognostic factors for PFS and OS in patients with HNSCC.ConclusionSerum CRP level is an independent prognostic marker for patients with HNSCC. CRP level could be regarded as a novel prognostic factor for HNSCC patients.

show abstract

“…It appears that CRP acts as the dominant ligand for the LOX-1 receptor. There is evidence that CRP is suggested as a ligand for LOX-1 and induced genes involved in tumorigenesis [33,34]. In addition to the ligands for LOX-1 and CD-36, direct bacterial interaction with these receptors may have caused the molecular changes observed in gastric cells.…”

Section: Discussionmentioning

confidence: 99%

The effect of Helicobacter pylori on the gastric expression of LOX-1 and CD-36: the role of CRP and ox-LDL

Ghanbariha

Dabiri

Mirmohammadkhani

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: This study aimed to investigate the effect of serum C-reactive protein (CRP) and oxidized low-density lipoprotein (ox-LDL) concentrations on the expression of lectin-like oxidized low-density lipoprotein (LOX-1) and cluster of differentiation 36 (CD-36) genes in gastric biopsies of individuals with and without Helicobacter pylori (H. pylori) infection.Methods and Results: In this cross-sectional study, we investigated 74 subjects based on gastritis and H. pylori infection in three groups. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of high-sensitivity CRP (hs-CRP) and ox-LDL. Quantitative real-time RT-PCR was run to compare LOX-1 and CD-36 gene expression.Comparison of LOX-1 gene expression in H. pylori and gastritis positive (P = 0.025) and H. pylori-negative and gastritis-positive (P = 0.010) to H. pylori and gastritis-negative groups showed a significant difference. CD-36 expression levels were lower in the H. pylori and gastritis positive group than in the non-gastritis and H. pylori group (p = 0.051). Although there was a weak correlation between serum hs-CRP concentration and LOX-1 expression (r = 0.219, P = 0.058), there was no correlation between serum levels of ox-LDL and LOX-1 expression and CD-36.Conclusion: Based on the investigation results, two factors, H. pylori, and gastritis increase LOX-1 expression and decrease CD-36 expression. Based on our results, an increase in plasma hs-CRP levels may be associated with an increase in LOX-1 expression.

show abstract

The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 19 publications

References 50 publications

Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination

Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

The effect of Helicobacter pylori on the gastric expression of LOX-1 and CD-36: the role of CRP and ox-LDL

Contact Info

Product

Resources

About