Prognostic role of pretreatment platelet/lymphocyte ratio in patients with non-small cell lung cancer

Abstract

Our study supports the view that a high basal PLR is a poor prognostic factor in NSCLC. However, the validity of the cut-off values for PLR identified in our study needs further prospective trials.

The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer

“…However, Song et al34 found that the LMR values at initial diagnosis and disease progression were similar in patients with early-stage NSCLC ( P =0.287), which suggested that LMR would not be predictive of DFS. In a previous study of patients with all stages of NSCLC, PLR was observed to be an independent prognostic factor 20. However, for early-stage NSCLC, some studies confirmed that PLR was not associated with survival 5,6,10.…”

“…Several previous studies have suggested that preoperative inflammatory markers, such as NLR, LMR, and PLR, are useful prognostic markers for patients with NSCLC 8,19,20. However, these studies focused on the pretreatment values of inflammatory markers.…”

Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer

“…Although the prognostic role of these indexes in NSCLC remains controversial, the results of the present study are in line with a clinical prognostic value. Several studies have identified that increased pretreatment NLR or PLR predicts shorter progression-free survival (PFS), DFS and OS in patients with NSCLC as well as poor response to first-line platinum-based treatment (16,18,20). Furthermore, other reports suggest that increased pretreatment PLT and FBG are significantly associated with unfavorable DFS, PFS or OS in patients with NSCLC (13)(14)(15)19,21,22).…”

“…In addition, inflammation prevents the adaptive immune response and is able to alter responses to systemic therapies (11,12). Numerous studies have revealed the association between inflammatory indexes and prognoses of patients with NSCLC, including platelet (PLT), fibrinogen (FBG), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). The study conducted by Unal et al (23) first identified the association between PLR and prognosis in patients with NSCLC, and suggested that assessing NLR and PLR together may predict the prognosis of patients with NSCLC.…”

Platelet-to-Lymphocyte Ratio and Use of NSAIDs during the Perioperative Period as Prognostic Indicators in Patients with NSCLC Undergoing Surgery

“…5 We previously reported the importance of the preoperative neutrophil-to-lymphocyte ratio in the context of NSCLC, indicating that those with a high preoperative inflammatory status have an elevated mortality risk; however, other investigated markers, including the platelet-to-lymphocyte ratio, have been shown to correlate with poor prognosis in various types of cancer. [6][7][8][9] The interaction between platelets and cancer cells, as well as between platelets and immune cells, has previously been described, and platelets may mediate tumor growth by stimulating angiogenesis and inducing immunosuppression through the release of growth factors. 10,11 The potential link between inflammation and cancer has been previously studied, and findings suggest that an inflammatory microenvironment promotes tumor growth, progression, and immunosuppression.…”