Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer

Abstract

Abstract. The aim of the present study was to investigate the prognostic value of the combined platelet (PLT), fibrinogen (FBG), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) (CO-NPF) for postoperative outcomes in patients with lung adenosquamous cancer (ASC). Test results from patients who presented at The Cancer Institute and Hospital of Tianjin Medical University between January 2005 and December 2013 were retrospectively reviewed. CO-NPF was scored between 0 and 4 according to increased PLT, FBG, NLR and PLR prior to being split into two groups based on the presence (≥2) or absence (<2) of the combination of increased inflammatory indexes. In total, data from 134 patients with ASC were reviewed for the present study. Multivariate analysis identified that increased CO-NPF (P= 0.001 and P<0.001, respectively), PLR (P=0.011 and P=0.001, respectively) and FBG (P=0.001 and P<0.001, respectively) were independently associated with shorter disease-free survival (DFS) and overall survival (OS). NLR (P=0.006) and PLT (P=0.001) were independent prognostic factors for OS. The area under the receiver operating characteristic curves of CO-NPF (area under the curve, 0.652, P= 0.008, 95% confidence interval, 0.551-0.752) was increased compared with NLR, PLR, PLT and FBG individually, suggesting that CO-NPF has greater predictive value. CO-NPF was significantly and independently associated with shorter DFS and OS, and had greater predictive value compared with NLR, PLR, PLT and FBG in patients with ASC who underwent surgery.

The impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio among patients with intrahepatic cholangiocarcinoma

“…34,35 The NLR, as a measure of this effect, can therefore be related to a worse prognosis in several solid tumors. [19][20][21][22][23][24][25] The present study confirmed the prognostic role of NLR among patients undergoing curative intent surgery for ICC. In contrast, PLR was not associated with survival.…”

“…Several previous studies have evaluated the prognostic role of NLR and PLR in different diseases. [20][21][22][23][24][25] A recent meta-analysis reported a strong correlation between NLR and poor postoperative outcomes for biliary tract cancers, 31 whereas other studies have suggested that PLR may have a prognostic role among patients with colorectal, hepatocellular, pancreatic, and ovarian cancers. 32,33 In addition, a recent study by our own group found that elevated preoperative NLR and PLR levels were associated with longterm prognosis among patients with pancreatic and secondary metastatic cancers of the liver.…”

“…NLR and PLR have been associated with poor survival among patients with several different types of cancers yet have not been examined relative to ICC prognosis. [20][21][22][23][24][25] Therefore, the objective of the present study was to define the prognostic impact of NLR and PLR among patients undergoing curative-intent resection for ICC. Furthermore, we sought to examine the relative change in predicting long-term prognosis with the addition of NLR and PLR to other established risk factors for ICC.…”

A Multi-parametric Prognostic Model Based on Clinical Features and Serological Markers Predicts Overall Survival in Non-small Cell Lung Cancer Patients With Chronic Hepatitis B Viral Infection

“…According to the results of LASSO, the present prognostic model consisting of 10 prognostic factors: age, BMI, tumor size, PLT, PLR, ALT, GGT, LDH, TBIL, and APOA. Among the 10 prognosis-speci c factors, all had been reported to be associated with overall survival in lung cancer patients [33][34][35][36][37][38][39][40][41][42][43]. These suggested that our analysis results hadcredible prognostic value.…”

Evaluation of Inflammation with Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Restless Legs Syndrome

“…The neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as markers of systemic inflammation recently. NLR and PLR measurements cost less than other inflammatory markers, and it is practical and easy to perform (7,15). In cases of various acute and chronic inflammatory conditions, NLR and PLR were found high in studies, and in the only study which studied NLR in patients with RLS, it was found that NLR was higher in the study group (7).…”