Prognostic Role of Hypoxic Inducible Factor Expression in Non-small Cell Lung Cancer: A Meta-analysis

Abstract

Introduction: Reported prognostic roles of hypoxic inducible factor (HIF) expression in non-small cell lung cancer (NSCLC) have varied. This meta-analysis aimed to examine the relationship between HIF expression and clinical outcome in NSCLC patients. Methods: PubMed were used to identify relevant literature with the last report up to December 20 th , 2012. After careful review, survival data were collected from eligible studies. We completed the meta-analysis using Stata statistical software (Version 11) and combined hazard ratio (HR) for overall survival (OS). Subgroup specificity, heterogeneity and publication bias were also assessed. All of the results were verified by two persons to ensure accuracy. Results: Eight studies were finally stepped into this meta-analysis in which seven had available data for HIF-1α and three for HIF-2α. Combined HRs suggested that higher expression of HIF1α had a negative impact on NSCLC patient survival (HR=1.50; 95%CI =1.07-2.10; p=0.019). The expression of HIF-2α was also relative to a poorer survival (HR=2.02; 95%CI =1.47-2.77; p=0.000). No bias existed in either of the two groups. Conclusion: This study suggests that elevations of HIF-1α and HIF-2α expression are both associated with poor outcome for patients with NSCLC. The data support further and high quality investigation of HIF expression for predicting poor outcome in patients with NSCLC.

High Expression of HIF-1α, BNIP3 and PI3KC3: Hypoxia-Induced Autophagy Predicts Cholangiocarcinoma Survival and Metastasis

“…We demonstrated that a hypoxia-inducible factor HIF-1α was positively expressed in CCA tissues in 66% of cases and was strongly correlated with shorter patients' survival. Our finding is consistent with previous studies revealing that HIF-1α correlated with shorter survival of breast cancer (Deb et al, 2014), lung cancer (Li et al, 2012), pancreatic cancer (Hoffmann et al, 2008), colorectal cancer (Baba et al, 2010) and Japanese type of intrahepatic CCA (Morine et al, 2010). In addition, it has :http://dx.doi.org/10.7314/APJCP.2014.15.14.5873 Hypoxia-Induced Autophagy Predicts Cholangiocarcinoma Survival and Metastasis been revealed that HIF-1α was presented in intrahepatic CCA tissues of Thai patients (Pinlaor et al, 2005), and in this study, we found that HIF-1α had a high expression in CCA patients with a shorter survival.…”

Genetic Variations in the HIF1A Gene Modulate Response to Adjuvant Chemotherapy after Surgery in Patients with Colorectal Cancer

“…Previous studies have found that HIF-1α overexpression indicates unfavorable prognosis and may serve as an potential prognostic factor in several cancers (Zhong et al, 1999;Marton et al, 2012;Wan et al, 2012;Li et al, 2013;Luan et al, 2013;Zhang et al, 2013;), including colon, breast , gastric, lung , skin, ovarian, pancreatic, prostate, and renal carcinomas. Furthermore, down-regulated HIF-1α expression in transplanted esophageal squamous cell carcinoma in vivo could enhance the cytotoxicity of cisplatin (Liao et al, 2012).…”

“…Similarly, another study has shown that HIF-1α over-expression is associated with the poor prognosis in a cohort of 731 CRC patients (Baba et al, 2010). In addition, HIF-1α has also been found to be associated with poor prognosis in several types of cancer, including hepatocellular carcinoma (Wada et al, 2006), gastric tumors (Zhang et al, 2013), non-small cell lung cancer (Li et al, 2013), and neuroendocrine breast cancer (Marton et al, 2012).…”

Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression

“…In lung cancer, tumor hypoxia is generally associated with disease progression and poor prognosis 30. Moreover, growing evidence suggests that tumor hypoxia is able to promote lung cancer growth and metastasis 9, 10.…”