Genetic Variations in the HIF1A Gene Modulate Response to Adjuvant Chemotherapy after Surgery in Patients with Colorectal Cancer

Zhang, Yi; Wang, Peng; Zhou, Xiaoting; Bao, Guoqiang; Lyu, Zhuo-Ming; Liu, Xiao‐Nan; Wan, Shaogui; He, Xianli; Huang, Qichao

doi:10.7314/apjcp.2014.15.11.4637

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…The genetic polymorphism rs2301113 in HIF1A was associated with the lung cancer outcome but not for colorectal cancer (3,32). On the other hand, the genetic polymorphism rs2057482 was associated with the efficiency of the chemotherapy in colorectal cancer patients (32) and with the prognosis of perimenopause coronary artery disease (33). In our study, we were not able to identify a polymorphism in HIF1A as a marker to the endodontic treatment outcome prognosis.…”

Section: Discussioncontrasting

confidence: 83%

“…Their gene expression analysis also indicated a possible mechanism of the less inflammatory state mediated by activation of HIF-1α through downregulation of NF-κB activation and subsequent proinflammatory gene expressions. The genetic polymorphism rs2301113 in HIF1A was associated with the lung cancer outcome but not for colorectal cancer (3,32). On the other hand, the genetic polymorphism rs2057482 was associated with the efficiency of the chemotherapy in colorectal cancer patients (32) and with the prognosis of perimenopause coronary artery disease (33).…”

Section: Discussionmentioning

confidence: 98%

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Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis

et al. 2018

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Persistent apical periodontitis (AP) is a situation involving an inflammatory and immune response caused mainly by anaerobic polymicrobial infection of the root canal system and the outcome and follow-up of the root canal treatment has been reported as intimately related to host response. The apical periodontitis repair might be associated with genetic polymorphisms. This study aimed to evaluate the association between HIF1A genetic polymorphisms (rs2301113 and rs2057482) with PAP in Brazilian patients. Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled. Sixty-four subjects with signs/symptoms of PAP and 84 subjects with root canal-treated teeth exhibiting healthy perirradicular tissues (healed) were included. Genomic DNA was extracted from saliva and used for HIF1A genotyping by real-time PCR. Genotype and allele frequencies were compared by c2 or Fisher's exact tests and odds ratio was implemented, using Epi Info 3.5.2. All tests were performed with an established alpha of 0.05. There was no association between allele and genotype distribution for HIF1As polymorphisms and PAP (p>0.05). The genetic polymorphisms in HIF1A were not associated with persistent apical periodontitis.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis

et al. 2018

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“…As explained above, the activated macrophages can stimulate angiogenesis process. Several studies described that angiogenesis is important in the development of breast cancer, and overexpression VEGF has been associated with advanced stage, metastasis and relapse-free survival or overall survival in breast tumors [ 8 – 11 , 56 , 57 ]. In our study, açaí treatment reduced VEGF and VEGFR-2 expression.…”

Section: Discussionmentioning

confidence: 99%

Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer

Alessandra-Perini

Perini

Rodrigues-Baptista

et al. 2018

BMC Complement Altern Med

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BackgroundAmong the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) and macrophages. Recently, the extract of Euterpe oleracea (açaí), a fruit that is widely found in the Amazon region, already showed antitumorigenic effects in vitro in human breast cancer cell lines. The present study aimed to investigate the effect of açaí on breast cancer using a chemically DMBA (7,12-dimethylbenzanthracene) experimental model.MethodsOne day after initiation of treatment with açaí, mammary carcinogenesis was induced in female Wistar rats using a subcutaneous injection of 25 mg/kg of DMBA in the mammary gland. Forty rats were randomized into two groups: treated with 200 mg/kg of either açaí extract or vehicle, via gastric tube for 16 consecutive weeks. After treatment, the tumor was collected for macroscopic, histological and immunohistochemical (VEGF, vascular endothelial growth factor receptor 2 -VEGFR-2, COX-2 and matrix metalloproteinase -MMP-9) analyses; peritoneal fluid was subjected to flow cytometry (F4–80/MAC-2+) and ELISA immunoassay (VEGF, prostaglandin E2 -PGE2 and interleukin-10 -IL-10). Heart, liver and kidney samples were collected for histological analysis.ResultsAfter 16 weeks of induction, the mammary carcinoma was confirmed by macroscopic and histological evaluation. Survival analysis indicates that açaí increased the survival (P = .0002, long-rank test) and reduced the deaths number (P = .0036, Chi-square test). Açaí treatment decreased the number of inflammatory cells and macrophage positive cells (Mac-2 + F4–80+), as well as promoting a reduction in immunostaining of VEGF, VEGFR-2 and COX-2. The açaí group also exhibited lower concentrations of PGE2, VEGF and IL-10 compared to the control. The histopathological results of the liver and kidneys showed protective effect of açaí, since in the control group, there was an increase in fibrosis, atypical cells and hemorrhagic microenvironment.ConclusionThe results of this study demonstrated the antiangiogenic and anti-inflammatory potential of açaí, like due to the decreases of the number of activated macrophages, resulting in the inhibition of DMBA carcinogenicity in breast cancer.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2183-z) contains supplementary material, which is available to authorized users.

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“…Class 2 includes 14 genes known to increase cancer susceptibility through germline variants. For example, HIF1A (16th by MUFFINN yet below 8000th by all three gene-centric methods in BRCA samples) polymorphism contributes to the risk of gastrointestinal cancer [ 41 ] and modulates the response to chemotherapy after surgery in patients with colorectal cancer [ 42 ]. Germline nucleotide variants in OBSCN (fifth by MUFFINN yet below 6000th by the gene-centric methods in papillary kidney carcinoma (KIRP) samples) were found in highly aggressive tumors such as glioblastoma, melanoma, and pancreatic carcinoma [ 43 ] and involved in cancer predispositions.…”

Section: Resultsmentioning

confidence: 99%

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

et al. 2016

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A major challenge for distinguishing cancer-causing driver mutations from inconsequential passenger mutations is the long-tail of infrequently mutated genes in cancer genomes. Here, we present and evaluate a method for prioritizing cancer genes accounting not only for mutations in individual genes but also in their neighbors in functional networks, MUFFINN (MUtations For Functional Impact on Network Neighbors). This pathway-centric method shows high sensitivity compared with gene-centric analyses of mutation data. Notably, only a marginal decrease in performance is observed when using 10 % of TCGA patient samples, suggesting the method may potentiate cancer genome projects with small patient populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-016-0989-x) contains supplementary material, which is available to authorized users.

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Genetic Variations in the HIF1A Gene Modulate Response to Adjuvant Chemotherapy after Surgery in Patients with Colorectal Cancer

Cited by 4 publications

References 26 publications

Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis

Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis

Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

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