Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma

Vergote, Ignace; Brabanter, Jos De; Fyles, Anthony; Bertelsen, K.; Einhorn, Nina; Sevelda, P.; Gore, Martin; Kærn, J.; Verrelst, Herman; Sjövall, K.; Timmerman, Dirk; Vandewalle, Joos; Gramberen, Marleen Van; Tropé, Claes G.

doi:10.1016/s0140-6736(00)03590-x

Cited by 571 publications

(343 citation statements)

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“…21 Among various histologic subtypes of ovarian carcinomas, serous carcinomas are frequently of high FIGO stage and high histologic grade, which usually have bad outcomes, whereas endometrioid carcinomas have a more favorable prognosis. 2,20 In addition, it has been reported that poorly differentiated papillary serous ovarian carcinomas express centrosome-related genes, including STK15/BTAK, at higher levels when compared to the well-differentiated counterparts.…”

Section: Discussionmentioning

confidence: 99%

Centrosome abnormalities in ovarian cancer

Hsu

Kapali

DeLoia

et al. 2004

Intl Journal of Cancer

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Centrosome abnormalities have been found in various cancer types and are thought to be involved in early development of cancer and/or progression. The contribution of centrosome abnormalities to ovarian tumorigenesis has not been previously evaluated. We sought to determine whether centrosome dysfunction occurs in ovarian tumorigenesis, and whether it could be used as an indicator of early neoplastic changes in ovarian surface epithelium (OSE). Primary cultures of normal OSE and ovarian tumors, as well as paraffin-embedded normal ovaries and ovarian tumors of different stages, were used for immunostaining with a ␥-tubulin antibody. Centrosomes were considered abnormal if there were more than 2 per cell, if their sizes were greater than 2-fold of a normal centrosome, and/or if they were abnormal in shape. Centrosomes in normal tissue were uniform in size, whereas centrosomes in ovarian tumors tended to be abnormal in size, number and shape. On average, 4.7% of cells in 5 primary normal OSE cultures had more than 2 centrosomes, whereas 14.1% of primary cells from 5 ovarian tumors displayed centrosome abnormalities (p ‫؍‬ 0.008). Centrosome abnormalities were present in 60.9% of stage I (n ‫؍‬ 23), 83.3% of stage II (n ‫؍‬ 30) and all stage III (n ‫؍‬ 10) paraffin-embedded ovarian tumor samples examined, but not in normal tissues. In addition, centrosome abnormalities occurred more frequently in ovarian tumors with higher grade and aggressive serous subtype. This is the first demonstration that centrosome abnormalities occur in ovarian tumors. Centrosome dysfunction may be an early event in ovarian carcinogenesis and involved in ovarian tumor progression.

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Section: Discussionmentioning

confidence: 99%

Centrosome abnormalities in ovarian cancer

Hsu

Kapali

DeLoia

et al. 2004

Intl Journal of Cancer

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“…In an earlier population-based study from Sweden, grade was found to be an independent prognostic factor, but the prognostic importance of the histopathologic subtypes was dependent on stage, especially the mucinous tumors (Hogberg et al, 1993). Vergote et al studied a group of 1545 patients with stage I disease and found that grade of disease was an independent prognostic factor associated with diseasefree survival (Vergote et al, 2001). In a study of OC patients from Norway from the 10-year period 1987-1996, no significance for either histopathologic subtype or grade could be shown (Tingulstad et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Arikan¹,

Kasap²,

Yetimalar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, adjuvant chemotherapy is found to be effective in patients with a high-grade disease staging (FIGO IC) [82] . Presently, the adjuvant therapy is found to depend on the tumor's stage and grade rather than its type [13] .…”

Section: Treatmentmentioning

confidence: 99%

Ovarian carcinoma: An overview of current status

Lugani¹,

Asthana²,

Labani³

2016

Adv Mod Oncol Res

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Abstract:Ovarian carcinoma is one of the leading causes of morbidity and mortality associated with carcinomas affecting women. It comprises a heterogeneous group of neoplasms that represents the seventh most lethal malignancy in women worldwide, and is a major cause of death from gynecological carcinoma. Specific to different geographical locations all over the globe, there are variations in the magnitude and trends of ovarian carcinoma, and the scenario of the disease keeps changing. As such, it is necessary to update and review the existing study on ovarian carcinoma. Reviews on ovarian carcinoma from 2000 to 2015 were extracted from PubMed and Google Scholar, and a few selected landmark studies that incorporated old data were also included. The focus of the present study is to consolidate an updated global view on epithelial ovarian carcinoma, the most prevalent type of ovarian carcinoma. This article covers the epidemiology, types, diagnosis, prognosis, and treatment of epithelial ovarian carcinoma.

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Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma

Cited by 571 publications

References 21 publications

Centrosome abnormalities in ovarian cancer

Centrosome abnormalities in ovarian cancer

Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Ovarian carcinoma: An overview of current status

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