Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Arikan, Sevim Kalsen; Kasap, Burcu; Yetimalar, Hakan; Yildiz, Aşkın; Sakarya, Derya Kilic; Tatar, Sumeyra

doi:10.7314/apjcp.2014.15.15.6087

Cited by 24 publications

(20 citation statements)

References 41 publications

(30 reference statements)

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“…The role of surgical cytoreduction in newly diagnosed epithelial ovarian cancer (EOC) has been widely accepted while an improvement in survival was shown in cases in whom residual disease was less than 0.5 cm or who had no residual disease, in particular (Bristow et al, 2002;Chi et al, 2006;Arikan et al, 2014). The role of secondary cytoreduction in recurrent EOC is less clear.…”

Section: Introductionmentioning

confidence: 99%

Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

Arvas¹,

Salihoğlu²,

Sal³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study was to determine the benefit of tertiary cytoreductive surgery (TC) for secondary recurrent epithelial ovarian cancer (EOC), focusing on whether optimal cytoreduction has an impact on disease-free survival, and whether certain patient characteristics could identify ideal candidates for TC. Materials and Methods: Retrospective analysis of secondary recurrent EOC patients undergoing TC at three Turkish tertiary institutions from May 1997 to July 2014 was performed. All patients had previously received primary cytoreduction followed by intravenous platinum-based chemotherapy and secondary cytoreduction for first recurrence. Clinical and pathological data were obtained from the patients' medical records. Survival analysis was caried out using the Kaplan Meier method. Actuarial curves were compared by the two tailed Logrank test with a statistical significance level of 0.05. Results: Median age of the patients was 49.6 years (range, 30-67) and thirty-eight (72%) had stage III-IV disease at initial diagnosis. Twenty six (49%) had optimal and 27 (51%) suboptimal cytoreduction during tertiary debulking surgery . Optimal initial cytoreduction, time to first recurrence, optimal secondary cytoreduction, time interval between secondary cytoreduction and secondary recurrence, size of recurrence, disease status at last follow-up were found to be significant risk factors to predict optimal TC. Optimal cytoreduction in initial and tertiary surgery and serum CA-125 level prior to TC were independent prognostic factors on univariate analysis. Conclusions: Our results and a literature review clearly showed that maximal surgical effort should be made in TC, since patients undergoing optimal TC have a better survival. Thus, patients with secondary recurrent EOC in whom optimal cytoreduction can be achieved should be actively selected.

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Section: Introductionmentioning

confidence: 99%

Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

Arvas¹,

Salihoğlu²,

Sal³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Epithelial ovarian cancer (EOC) accounts for 80-90% in all ovarian cancers and is one of the most lethal gynecologic malignancies (Arikan et al, 2014;MhawechFauceglia et al, 2014). An estimated 1 out of 70 women is under life-threatening risk of EOC worldwide (Siegel et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells

Patel

Singh²,

Kumar³

2015

Asian Pacific Journal of Cancer Prevention

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“…The survival rate of ovarian cancer patients is only 40% in all stages and 15%-30% patients with widespread metastatic disease survive 5 years after the initial treatment (Vaughan et al, 2011). Mortality risk increased 3.44-fold in patients over 50 years of age, 2.75 times in the presence of lymph node invasion (Arikan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Metastasis and Invasion of Ovarian Cancer Cells by Crude Polysaccharides from Rosa Roxburghii Tratt in Vitro

Chen

Liu²,

Liu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Cited by 24 publications

References 41 publications

Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells

Inhibition of Metastasis and Invasion of Ovarian Cancer Cells by Crude Polysaccharides from Rosa Roxburghii Tratt in Vitro

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