Prognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma

Kim, Baek Hui; Hong, Soon Won; Kim, Aeree; Choi, Seung Ho; Yoon, Sun Och

doi:10.1002/jso.23271

Cited by 96 publications

(93 citation statements)

References 24 publications

(54 reference statements)

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“…After manually screening the titles, abstracts and key data, 259 records were excluded for not meeting the criteria listed above. Of the 28 reports selected for the systematic review, 12 studies were excluded in the final meta-analysis for lack of key HR value [21][22][23][24][25][26][27][28][29][30][31][32]. The excluded 12 studies commonly focused on other miRNAs and did not analyze the miR-155 data individually.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

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Abstract. BACKGROUND:Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

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“…The high expression of miR-106a was previously demonstrated to indicate a high risk of tumor penetration in advanced gastric carcinoma (52) and mediate proliferation and tumor differentiation in ovarian cancer through direct targeting of retinoblastoma-like protein 2, a member of the retinoblastoma tumor suppressor family (53). High expression levels of miR-20a are associated with lymph node metastasis in advanced gastric carcinoma (52). Recently, a report indicated that miR-20 was able to downregulate Fas expression, thus contributing to the metastatic potential of OS cells (54).…”

Section: Discussionmentioning

confidence: 96%

“…However, an oncogenetic function was proposed for a number of these miRNAs, based on their ability to target tumor suppressor genes. The high expression of miR-106a was previously demonstrated to indicate a high risk of tumor penetration in advanced gastric carcinoma (52) and mediate proliferation and tumor differentiation in ovarian cancer through direct targeting of retinoblastoma-like protein 2, a member of the retinoblastoma tumor suppressor family (53). High expression levels of miR-20a are associated with lymph node metastasis in advanced gastric carcinoma (52).…”

Section: Discussionmentioning

confidence: 98%

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

Li¹,

Zhang²,

Liu³

et al. 2015

Oncology Letters

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Abstract. MicroRNAs (miRNAs) are a family of small non-protein coding RNAs, which regulate the expression of a wide variety of genes at the post-transcriptional level to control numerous biological and pathological processes. Various circulating miRNAs have been identified as potential diagnostic and prognostic biomarkers in multiple types of cancer and disease. The aim of the present study was to identify potential miRNA biomarkers for the early diagnosis and relapse prediction of osteosarcoma (OS). miRNA profiling was performed on serum from patients with osteosarcoma and healthy controls. All putative miRNAs were verified by reverse transcription-quantitative polymerase chain reaction analysis of 20 pre-therapeutic OS patients and 20 healthy individuals. The expression of miR-106a-5p, miR16-5p, miR-20a-5p, miR-425-5p, miR451a, miR-25-3p and miR139-5p was demonstrated to be downregulated in the serum of OS patients when compared with that of the healthy controls. Receiver-operating characteristic curve analyses indicated that these 7 miRNAs may be used as diagnostic biomarkers with the ability to discriminate between the healthy cohort and patients with OS. These results provide novel insights into the use of miRNAs in early blood screening for OS.

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“…However, it was previously demonstrated that upregulation of miRNA occurs in certain types of tumor (24). It was hypothesized that miRNAs are able to act as oncogenes or as tumor suppressors, depending on the type of tissue and the context in which they are expressed (25,26). Knowledge of the underlying molecular mechanism of miRNAs in cancer remains limited.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-548c-3p inhibits T98G glioma cell proliferation and migration by downregulating c-Myb

Zhang

Xiao

et al. 2017

Oncology Letters

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Abstract. MicroRNAs (miRNAs/miRs) are short non-coding RNAs (between 20 and 22 nucleotides) that regulate gene expression by binding to the 3'-untranslated region of target mRNA, and preventing protein translation or inducing mRNA destabilization. miRNAs are predicted to target ~60% of all mRNAs, therefore providing a marked degree of regulation of a number of cellular processes. In the present study, the expression of miR-548c-3p was determined by reverse transcription-quantitative polymerase chain reaction analysis and demonstrated to be markedly downregulated in clinical malignant glioma tissues and the glioma T98G cell line compared with normal human brain tissue. Transfection of miR-548c-3p inhibited cell proliferation by inducing G 1 cell cycle arrest and also inhibited the migration of the T98G cells in vitro. Furthermore, a bioinformatic algorithm and a luciferase reporter assay identified proto-oncogene c-Myb (c-Myb) as a potential direct target of miR-548c-3p. Further experiments demonstrated that the inhibition of c-Myb by miR-548c-3p partially mediated the antitumor effect of miR-548c-3p. The results of the present study provide the novel insight that miR-548c-3p inhibits glioma tumorigenesis by targeting c-Myb. Therefore, miR-548c-3p may contribute to the development of improved glioma treatment.

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Prognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma

Cited by 96 publications

References 24 publications

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

MicroRNA-548c-3p inhibits T98G glioma cell proliferation and migration by downregulating c-Myb

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