Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study

Alseoudy, Mahmoud M.; Elgamal, Mohamed; Abdelghany, Dalia A.; Borg, Asmaa M.; El-Mesery, Ahmed; Elzeiny, Dina; Hammad, Maha O.

doi:10.1016/j.clim.2022.108929

Cited by 22 publications

(24 citation statements)

References 41 publications

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“…However, a follow-up study could not reproduce these results [ 30 ]. In addition, a TLR3 (rs3775290) polymorphism has been associated with an increased risk of pneumonia in patients with COVID-19 [ 31 ]. Further studies are needed to define the role of TLR3 in SARS-CoV-2 infection and the development of COVID-19.…”

Section: Innate Immune Sensing and Signaling In Response To Sars-cov-2mentioning

confidence: 99%

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

Karki

Kanneganti

2022

J Transl Med

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The innate immune system serves as the first line of defense against invading pathogens; however, dysregulated innate immune responses can induce aberrant inflammation that is detrimental to the host. Therefore, careful innate immune regulation is critical during infections. The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in global morbidity and mortality as well as socio-economic stresses. Innate immune sensing of SARS-CoV-2 by multiple host cell pattern recognition receptors leads to the production of various pro-inflammatory cytokines and the induction of inflammatory cell death. These processes can contribute to cytokine storm, tissue damage, and acute respiratory distress syndrome. Here, we discuss the sensing of SARS-CoV-2 to induce innate immune activation and the contribution of this innate immune signaling in the development and severity of COVID-19. In addition, we provide a conceptual framework for innate immunity driving cytokine storm and organ damage in patients with severe COVID-19. A better understanding of the molecular mechanisms regulated by innate immunity is needed for the development of targeted modalities that can improve patient outcomes by mitigating severe disease.

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Section: Innate Immune Sensing and Signaling In Response To Sars-cov-2mentioning

confidence: 99%

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

Karki

Kanneganti

2022

J Transl Med

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“… 94 It was demonstrated that the TLR3 rs3775290 and TLR7 rs179008 genotypes were significantly associated with increased risk of COVID‐19 pneumonia but not the disease outcome. 95 They also found that males with TLR3 SNP (T/T polymorphism) were more susceptible to the disease. TLR7 rs179008 genotype has been also associated with lower expression levels and additionally, HCV and HIV infection with alteration in responses.…”

Section: Tlrs Genes Polymorphismsmentioning

confidence: 98%

“…The intron variant in the IFNAR2 gene (rs2236757) and Interferon‐inducible transmembrane ( IFITM ) genes such as IFITM3 rs12252 genotype has been associated with SARS‐COV‐2 infection 94 . It was demonstrated that the TLR3 rs3775290 and TLR7 rs179008 genotypes were significantly associated with increased risk of COVID‐19 pneumonia but not the disease outcome 95 . They also found that males with TLR3 SNP (T/T polymorphism) were more susceptible to the disease.…”

Section: Tlrs Genes Polymorphismsmentioning

confidence: 99%

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease

Vakil

Mansoori

Al-Awsi

et al. 2022

Journal of Medical Virology

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Innate and acquired immunity responses are crucial for viral infection elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storms which poses severe respiratory conditions in coronavirus disease-19 (COVID-19). Host genetic variations in particular those related to the immune responses determine the patients' susceptibility and COVID-19 severity and pathophysiology. Gene polymorphisms such as single nucleotide polymorphisms (SNPs) of interferons, TNF, IL1, IL4, IL6, IL7, IL10, and IL17 predispose patients to the severe form of COVID-19 or severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). These variations mainly alter the gene expression and cause a severe response by B cells, T cells, monocytes, neutrophils, and natural killer cells participating in a cytokine storm. Moreover, cytokines and chemokines SNPs are associated with the severity of COVID-19 and clinical outcomes depending on the corresponding effect. Additionally, genetic variations in genes encoding toll-like receptors (TLRs) mainly TLR3, TLR7, and TLR9 have been related to the COVID-19 severe respiratory symptoms. The specific relation of these mutations with the novel variants of concern (VOCs) infection remains to be elucidated. Genetic variations mainly within genes encoding proinflammatory cytokines, cytokine receptors, and TLRs predispose patients to COVID-19 disease severity. Understanding host immune gene variations associated with the SARS-COV-2 infection opens insights to control the pathophysiology of emerging viral infections.

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“…The sequence of primers used in molecular analysis of this study was detailed in table (1). To examine the optimum annealing temperature of primer, the DNA template was amplified with the same primer pair, (Forward) (Reverse), at annealing temperatures of 55, 58, 60, 63 and 65°C.…”

Section: Primer Preparation and Optimizationmentioning

confidence: 99%

“…In December 2019, a novel infectious disease, called COVID-19 pneumonia, emerged in Wuhan City, China, and is spreading globally. Unfortunately, the ultimate fate of the COVID-19 pneumonia outbreak is unknown, as the situation is rapidly evolving [1]. The innate immune system provides the first-line protection against invading organisms and it is potentially important in SARS-CoV-2 infection [2].…”

Section: Introductionmentioning

confidence: 99%

Exploring the significant role of TLR 7 gene polymorphism with severity infection of COVID-19 patients in Wasit province

Hussein

Mohammed

2022

ijhs

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Toll-like receptor 7 (TLR7 genes was involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR7 (rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia accompanying SARSCOV-2 infection. This case-control study included 120 individuals: 80 COVID-19 patients (severe and mild) and 40 controls. Polymorphisms (TLR7 rs179008) were genotyped by Sanger sequencing using ABI3730XL, automated DNA sequencer, by Macrogen Corporation – Korea after sent PCR products. This study also investigated predictors of mortality in COVID-19 severity through logistic regression. The mutant‘T/T' genotypes and the ‘T' alleles of TLR7 (rs179008) polymorphisms were significantly associated with increased risk of COVID-19 severity. Our study illustrated that the males harbouring the TT genotype of TLR7 rs 170008 polymorphism could be more susceptible to COVID-19 pneumonia than females having the same genotype.

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Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study

Cited by 22 publications

References 41 publications

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease

Exploring the significant role of TLR 7 gene polymorphism with severity infection of COVID-19 patients in Wasit province

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