Prognostic factors in patients with glioblastoma multiforme (clinical research)

Ekici, Mehmet; Bulut, Turgay; Tucer, Bülent; Başarslan, Seyit Kağan; Kurtsoy, Ali

doi:10.3906/sag-1204-45

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…We also found that patients received ACT had a significant impact on OS, with median OS of 15 months versus 10 months in patients received RT only, and this coincides with what was reported by Ekici et al [26].…”

Section: Discussionsupporting

confidence: 91%

Outcome of High Grade Gliomas in Limited Resource Country (10 Years’ Experience in Alexandria University Oncology Center 2003-2012)

Barakat¹,

Belal²,

Fadel³

et al. 2016

J Brain Tumors Neurooncol

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Background: Gliomas are the most common form of malignant primary brain tumors in adults with an annual incidence of approximately five per 100,000 people. In Egypt, primary Central Nervous System (CNS) neoplasms are rare, constituting about 1-2% of all human neoplasms, with High Grade Gliomas (HGGs) being the most common type. The study aims to discover the histo-pathological aspect of HGGs, risk factors, and descriptive analysis of treatment received in Clinical oncology department affiliated with Alexandria University Hospital. Methods: Data were collected and analyzed for four hundred and thirty four patients with histologically proven HGGs in the period between 2003 and 2012. Results: Age of patients ranged from 21 to 83 years. Most cases (80.4%) were Glioblastoma Multiform (GBM), followed by Anaplastic Astrocytoma (AA) reaching14.3% of patients. In this study, 45.4% of patients had karnofsky performance score (KPS) more than 60%. Only 2.5% of patients underwent gross total resection (GTR), 25.6% underwent Subtotal Resection (STR) and 50% of patients underwent excisional biopsy. Patients received radiotherapy were 355 about 81.8% of patients with HGGs (80.2% of them received Radiotherapy (RT) only, 11.8% received RT followed by Adjuvant Chemotherapy (ACT), 4% received Concomitant Chemoradiotherapy (CCRT) and 4% received CCRT followed by ACT), 16.6% of patients received only best supportive care (BSC) and 2.3% did not receive treatment. The median Overall Survival (OS) was 10, 13, 19 and 15 months for patients received RT only, CCRT, CCRT followed by ACT and RT followed by ACT, respectively. Conclusion: Delayed presentation and inadequate GTR together with unavailability of TMZ could affect outcome in limited resource countries.

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Section: Discussionsupporting

confidence: 91%

Outcome of High Grade Gliomas in Limited Resource Country (10 Years’ Experience in Alexandria University Oncology Center 2003-2012)

Barakat¹,

Belal²,

Fadel³

et al. 2016

J Brain Tumors Neurooncol

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“…First time in an assay it was described that simultaneous TMZ (temozolomide) and radiotherapy increased median survival rates up to 26.5% within 24 months, a vast improvement over the 10.4% with radiotherapy alone (41). Ekici et al (2013) showed that combined chemotherapy and radiotherapy offered good prognosis with a treatment value (15). In this line, Barker et al asserted that there was a good outcome in old patients, when TMZ was accompanied to radiotherapy (42).…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary standard therapy including surgical resection, combined radiation and chemotherapy and adjuvant chemotherapy can be considered for removing the remained glioma cells and increasing survival chance (12)(13). Since patients with KPS≥70 indicated better prognosis than ones with KPS<70, it should be noted that the level of functional outcome according to KPS plays an important role in determining the degree of prognosis which can guide the clinicians to decide for choosing the appropriate medical therapeutic regimens to remedy GBM sufferers (14)(15). This study has two mainstays.…”

Section: Introductionmentioning

confidence: 99%

Glioblastoma Multiforme: A Single Hospital Experience

Behzadnia

Alijani

Emamhadi

et al. 2015

IrJNS

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Background & Aim: Glioblastoma multiforme (GBM), the highest grade glioma (grade IV), is the most malignant form of astrocytoma in adults. This study aimed at evaluating the relationship between demographic, clinical and medical factors with GBM outcome. Methods & Materials/Patients: Through a cross-sectional design, 58 patients with newly diagnosed GBM were studied from 1999 to 2015 in Guilan province (North of Iran). Demographic, clinical and medical data including age, gender, score of Karnofsky Performance Scale (KPS), status at discharge, extent of resection (EOR) and administration of post-operative radio-chemotherapy were recorded in an individual questionnaire. The data were analyzed using chi-square and fisher exact tests. Results: Of all patients, 35 (60.3%) cases were men and 23 (39.7%) were women. Age range (at the time of diagnosis of GBM) was 18-82 years (54.86±16.34). The most common side and location of tumor were left hemisphere and frontal lobe, respectively. 41 patients (70.7%) received total surgical resection. Half of patients were treated with simultaneous post-operative radiation therapy and chemotherapy.11 (19%) of all cases died. About 41 (70.6%) of patients demonstrated KPS 50-70. Conclusion: GBM is a frequent malignant brain tumor with male predominance and high occurrence in age range of ≥50 years. The number of dead patients increases with decreased KPS. Total surgical resection followed by concomitant radiation therapy and chemotherapy were common standard therapeutic regimens.

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