Prognostic Factors and Survival of Glioblastoma Multiform (GBM) in Iranian Patients

Rajabpour, Mojtaba Vand; Yahyazadeh, Hossein; Beheshti, Marzieh

doi:10.5812/ijcm.6260

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…Correlating the available clincopathological features including the survival data of GBM cases with the gene expression results revealed that poor overall survival and disease-free survival were found significantly among patients as reported by previous studies [ 44 , 45 ]. Despite that GBM can occur in individuals of any age according to the previous population-based studies, the median age is nearly above 60 years.…”

Section: Discussionsupporting

confidence: 75%

Longevity‐Related Gene Transcriptomic Signature in Glioblastoma Multiforme

Fawzy

Badran

Ageeli

et al. 2018

Oxidative Medicine and Cellular Longevity

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Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease.

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Section: Discussionsupporting

confidence: 75%

Longevity‐Related Gene Transcriptomic Signature in Glioblastoma Multiforme

Fawzy

Badran

Ageeli

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Moreover, good perioperative physical and neurological conditions of iGBM patients contribute to tolerance to general anesthesia and complete chemoradiation therapy. As a result, the median PFS and OS of iGBM patients (11.5 and 20.0 months, respectively) were better than previous reports (6.3-7.1 months and 10.1-15.2 months) [9,10,13,15,27]. It is worth noting that the general patient demographics and molecular features of iGBM were not different from those of general GBM.…”

Section: Discussionmentioning

confidence: 55%

“…Even with the best treatment with maximal safe surgical resection following chemoradiotherapy with temozolomide, the median overall survival of GBM patients does not reach two years [7]. The representative prognostic factors of GBM patients include age, Karnofsky performance score (KPS), molecular diagnosis including isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and O-6methylguanine deoxyribonucleic acid methyltransferase (MGMT) promoter methylation status, and the extent of initial surgical resection [8][9][10][11][12][13][14]. Additionally, a small preoperative contrast-enhanced tumor on imaging is an independent favorable prognostic factor [15].…”

Section: Introductionmentioning

confidence: 99%

The clinical characteristics and outcomes of incidentally discovered glioblastoma

Kawauchi¹,

Ohno²,

Honda‐Kitahara³

et al. 2022

J Neurooncol

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With an increase in the number of imaging examinations and the development of imaging technology, a small number of glioblastomas (GBMs) are identi ed by incidental radiological images. These incidentally discovered glioblastomas (iGBMs) are rare, and their clinical features are not well understood. Here, we investigated the clinical characteristics and outcomes of iGBM. MethodsData of newly diagnosed iGBM patients who were treated at our institution between August 2005 and October 2019 were reviewed. An iGBM was de ned as a GBM without a focal sign, discovered on radiological images obtained for reasons unrelated to the tumor. Kaplan-Meier analysis was performed to calculate progression-free survival (PFS) and overall survival (OS). ResultsOf 234 patients with newly diagnosed GBM, four (1.7%) were classi ed as having iGBM. Health screening was the most common reason for tumor discovery (75.0%). The preoperative Karnofsky performance status score was 100 in three patients. Tumors were found on the right side in three cases. The mean volume of preoperative enhanced tumor lesion was 16.8 cm 3 . The median duration from con rmation of an enhanced lesion to surgery was 13.5 days. In all cases, either total (100%) or subtotal (95-99%) resections were achieved. The median PFS and OS were 11.5 and 20.0 months, respectively. ConclusionsThe iGBMs were often small and in the right non-eloquent area, and the patients had good performance status. We found that timely therapeutic intervention provided iGBM patients with favorable outcomes. This report suggests that early detection of GBM may lead to a better prognosis.

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“…Previous studies have identi ed that other than a tumor located in the periventricular zone, the risk factors for LMD are long survival [9], young age [7,9], larger initial tumor size [7],and MGMTpromoter methylation [6].Patients with ITDhave a longerOS (19.7 months) than the general GBM population (10.1-15.2 months) [25][26][27][28][29].By contrast, the median age of the patients(66.0 years)is consistent with that of the patients with GBM (63-65 years) [27,[30][31][32].Moreover, the MGMTpromoter'slow methylation status (21.4%) in the patients was lower than that in the general GBM population (45%) [33]. and the extent of resection (total resection 28.6%) did not exceed previous reports (20-43%){Chang, 2005 #13} [30,34].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Prognosis of Patients with Glioblastoma with Infratentorial Leptomeningeal Dissemination

Kawauchi

Ohno

Honda‐Kitahara

et al. 2022

Preprint

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Objective: Leptomeningeal dissemination (LMD) is a severe complication of glioblastoma (GBM) and has become a more common and indispensable clinical proposition with improved patient prognosis. Although infratentorial leptomeningeal dissemination (ITD) of GBM is rare, it is clinically significant as it may largely influence patient prognosis. Here, we investigated the clinical characteristics and prognosis of patients with ITD.Methods: Data of patients with newly diagnosed isocitrate dehydrogenase (IDH)-wildtype GBM treated at our institution between October 2008 and December 2018 were reviewed. ITD was defined as the dissemination of GBM, which first emerged as a supratentorial tumor, and later disseminated in the infratentorial region as the first recurrent site.Results: Of 160 patients with newly diagnosed IDH-wildtype GBM, seven (4.4%) were classified as having ITD. ITD lesions were in the fourth ventricle in two patients, extra-cerebellum or extra-brainstem in two, and intra-cerebellum in three. The primary symptoms of ITD were gait disturbance (85.7%, n=6), nausea and vomiting (28.6%, n=2), cerebellar mutism (14.3%, n=1), and none (14.3%, n=1). In four cases (57.1%), symptoms were confirmed before ITD discovery.The median progression-free survival (PFS) and overall survival of the patients were 12.2 and 19.7 months, respectively. Radiotherapy was performed in five patients, and all the patients received chemotherapy. The PFS and overall survival rates from ITD diagnosis were 2.9 and 7.1 months, respectively. Patients with favorable prognoses were younger and had higher Karnofsky performance status (KPS) scores.Conclusions: Radiotherapy or molecular-targeted therapy may be effective in some cases of ITD and may contribute to extending survival. Carefully checking the infratentorial region of patients with GBM during follow-up and rapidly treating ITD before their KPS score starts declining are crucial.

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Prognostic Factors and Survival of Glioblastoma Multiform (GBM) in Iranian Patients

Cited by 5 publications

References 14 publications

Longevity‐Related Gene Transcriptomic Signature in Glioblastoma Multiforme

Longevity‐Related Gene Transcriptomic Signature in Glioblastoma Multiforme

The clinical characteristics and outcomes of incidentally discovered glioblastoma

Clinical Characteristics and Prognosis of Patients with Glioblastoma with Infratentorial Leptomeningeal Dissemination

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