Background: Glioblastoma Multiform has been a common and fatal brain tumor. In this regard, there was ambiguity around patient survival rates in Iran que to data insufficiency. In this study, we have analyzed the overall and progression free survival in GBM patients at Milad Tehran hospital.
Background: Lymphovascular invasion (LVI) and perineural invasion (PNI) are relatively common in various malignancies including colorectal cancers and have been shown to have prognostic significance. Objectives: The aim of this study was to identify the clinical and pathological variables associated with LVI and PNI in patients with colorectal carcinoma, who have been treated at Milad General Hospital in Tehran, Iran. Methods: The records of the patients with the diagnosis of colorectal carcinoma, who had undergone an operation at Milad General Hospital (Tehran, Iran) between 2012 and 2017, were reviewed. All patients, whose pathology reports and treatment records were available at Milad Hospital, were included. Relevant demographic, pathological, and surgical data, including age, gender, tumor location, maximum tumor size, pathologic Tumor, Node, Metastasis (TNM) stage, and grade and number of removed lymph nodes were extracted from the medical records. Results: In total, 547 patients (374 cases of colon cancer and 173 cases of rectal cancer) enrolled in the study. The prevalence of LVI and PNI was 16.4% and 30.7%, respectively. LVI and PNI were found to be associated with higher tumor grade, higher T-stage, and higher overall stage. Conclusions: Colorectal carcinomas with positive LVI or PNI are more likely to have a higher grade, higher T-stage, and higher overall stage, and PNI is an independent factor for advanced disease.
Background: Colorectal cancer is a highly prevalent cancer around the world and Iran. There are different criteria that can affect the survival rate of this disease. Surgical margin status is one of these criteria; there are still challenges about how it can change the surveillance of the disease. Objectives: In this study, we assessed the relativity between surgical margin status and the stage of disease in Iranian patients suffering from colorectal cancer. Methods: This is an observational cross-sectional study. A total of 797 patients with colorectal cancer were included and a checklist of demographic, clinical, and pathological data was filled for each one. Based on the pathology result of the biopsy, the patients were divided into different histological groups. Surgical margin status was defined individually. To declare the relativity between surgical margin status and independent variables, we used Spearman's rho test.
Results:The stage of the disease and its histological type and grade were significantly correlated. There was also a significant correlation between histological grade and type of the disease. Conclusions: Surgical margin status and stage of the disease are challenging prognostic factors in disease recurrence and survival. The patients who participated in this study had meanly higher age and stage of diagnosis than earlier studies either global or local. It can be due to a lack of a systematic program for early detection of CR cancer in Iran that emphasizes the necessity of GI screening systems.
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