Prognostic factors for long‐term poor outcomes after acute ischemic stroke in very old age (>80 years) patients: Total cholesterol level might differently influence long‐term outcomes after acute ischemic stroke at ages above 80 years

Abstract

There were also some differences in related factors regarding occurrences of poor outcome between the two groups. In particular, the initial TC level might play a crucial role for the outcome after AIS in the very old population.

Clinical characteristics of atrial fibrillation‐related cardioembolic stroke in patients aged 80 years or older

“…Patients aged ≥80 years were more frequently women, and were more likely to have higher premorbid mRS, lower body mass index, previous history of stroke, prior antiplatelet therapy and CHF, but less likely to have dyslipidemia, compared with those aged <80 years. These differences in clinical characteristics were similar to those observed in entire ischemic stroke in elderly patients . Additionally, we found that persistent AF was more common in patients aged ≥80 years.…”

“…The clinical characteristics and outcomes in elderly patients with ischemic stroke are different from younger patients. Patients aged ≥80 years with ischemic stroke are more frequently female, and more frequently have hypertension, AF, previous history of stroke, premorbid disability, coronary artery disease, peripheral artery disease, prior antiplatelet therapy, more severe stroke symptoms, neurological worsening and post‐stroke medical complications, but less frequently have obesity, diabetes mellitus, hyperlipidemia, smoking habits and alcohol consumption, compared with those aged <80 years . Furthermore, patients with ischemic stroke aged ≥80 years have higher case‐fatality and disability rates than patients aged <80 years …”

“…Patients aged ≥80 years with ischemic stroke are more frequently female, and more frequently have hypertension, AF, previous history of stroke, premorbid disability, coronary artery disease, peripheral artery disease, prior antiplatelet therapy, more severe stroke symptoms, neurological worsening and post-stroke medical complications, but less frequently have obesity, diabetes mellitus, hyperlipidemia, smoking habits and alcohol consumption, compared with those aged <80 years. [6][7][8][9][10][11][12][13][14] Furthermore, patients with ischemic stroke aged ≥80 years have higher case-fatality and disability rates than patients aged <80 years. 6,7,9,[11][12][13][14] However, the differences in clinical characteristics and outcomes of patients aged ≥80 years with specific AF-related cardioembolic stroke remain unclear.…”

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study

“…Several large-scale studies demonstrated that lower TC levels were associated with higher all-cause mortality and that higher TC levels were associated with lower all-cause mortality [45, 46]. Furthermore, a U-shaped association between TC level and dependency after AIS was shown in a group of people of very old age; patients with moderate TC levels had the most favorable outcomes after AIS in patients aged >80 years [47]. Moreover, our previous study indicated that low cholesterol levels among patients with atherothrombotic infarction receiving statin treatment increased long-term dependency and recurrence rates, but not mortality rates [48].…”

Serum lipid anomalies in adult patients with acute ischemic stroke

“…AIS severity and initial total cholesterol levels independently influence the outcome in 374 out of 2 772 patients, or in 13.49% of the cases who are aged >80 years (14). Based on an observational study using data from the Get-With-The-Guidelines-Stroke Registry including 913 436 patients with AIS or transient ischemic attack it is concluded that management of dyslipidemia in high-risk patients continues to be suboptimal as only one out of five such patients presented with optimal admission LDL values <70 mg/dL (15).…”