Prognostic Factors Depicting Disease-Specific Survival in Parotid-Gland Tumors

Koul, Rashmi; Dubey, Arbind; Butler, James; Cooke, Andrew; Abdoh, Ahmed A.; Nason, Richard W.

doi:10.1016/j.ijrobp.2007.01.009

Cited by 50 publications

(49 citation statements)

References 17 publications

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“…In several reviews [8Á10,20], it has been reported that tumour size, malignancy grade and extent of the tumour are major determinants predicting survival, which we also observed. Presence of lymph node metastases implies a larger risk of recurrence and worsens the prognosis in our study, as confirmed by others [6,8,10,11,16]. It is consistent with our findings that patients with more advanced disease have a much poorer outcome in terms of overall survival and recurrence rate.…”

Section: Discussionsupporting

confidence: 93%

“…As in other studies, gender had no impact on survival [8,12]. In several reviews [8Á10,20], it has been reported that tumour size, malignancy grade and extent of the tumour are major determinants predicting survival, which we also observed.…”

Section: Discussionsupporting

confidence: 82%

“…Postoperative radiotherapy has been used as standard treatment since the 1970s in our material and is recommended in several recently published studies [8,12,13]. However, the role of radiotherapy has been debated by several authors through the years but there now seems to be agreement that nonradical surgery, inoperable tumour due to tumour extension and more advanced stages require adjuvant radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice for malignancies of the parotid gland, as in other salivary gland tumours, is surgery with or without adjuvant radiotherapy [1,2,8]. The aim of the surgery is to remove the tumour radically without compromising the facial nerve.…”

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confidence: 99%

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Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

et al. 2009

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

et al. 2009

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“…T stage, lymph node status, age and grade of the tumors remain the most important prognostic variables for salivary gland malignancy (Spiro, 1986;Hocwald et al, 2001;Lima et al, 2005;Koul et al, 2007). Some studies have also demonstrated perineural invasion as an independent predictor of survival (Garden et al, 1997;Hocwald et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on major salivary gland tumor management and outcome from Pakistan. The objective of this study was to share our experience with management of malignant tumors of major salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum Cancer Hospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivary gland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regional and distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculated using Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazard regression. Results: The parotid gland was the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cystic carcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained the mainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery alone and 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one (32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFS and OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictor of DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employing existing standards of treatment, comparable survival can be achieved in Pakistani population with major salivary gland malignancies as elsehwere in the world.

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Racial and Ethnic Disparities in Salivary Gland Cancer Survival

Russell

Chen

Ortiz

et al. 2014

JAMA Otolaryngol Head Neck Surg

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Importance Several recent studies have documented disparities in head and neck cancer outcomes for Black patients in the United States. However, few studies have been conducted to evaluate for differences in long-term survival from salivary gland cancer (SGCA) for racial/ethnic minorities compared to Whites. Objective To determine if patient race or ethnicity impact SGCA survival. Design, Setting, and Participants Retrospective survival analysis of all patients with SGCA from 1988–2010 in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database, a population-level database of cancer registries covering approximately 28 percent of the US population. Intervention None Main Outcomes and Measures The primary outcome measured was disease-specific survival. Patients with SGCA were grouped according to race and ethnicity. The end points assessed in each group included age at diagnosis, gender, tumor grade, tumor size at diagnosis, extension at diagnosis, lymph node involvement at diagnosis, and treatment modalities. The racial/ethnic groups were further analyzed by histologic subtype of the SGCAs. Results Of 11,007 patients with SGCA, 1,073 (9.7%) and 1,068 (9.7%) were Black and Hispanic, respectively. The mean age at diagnosis for Whites was 63 years old compared to 53 and 52 years old for Blacks and Hispanics, respectively (p < 0.0001). Twenty-year disease-specific survival rates for all SGCA histologies combined for Whites, Blacks, and Hispanics were 78%, 79%, and 81%, respectively. The log-rank test of the unadjusted survival curves showed no significant difference in survival between Black and White patients and an apparent survival advantage for Hispanic compared to White patients. However, using multivariable Cox regression models to control for patient, tumor, and treatment characteristics, we demonstrated that Black patients actually have significantly poorer disease-specific survival for SGCA compared to White patients, while Hispanic patients have no significant difference in disease-specific survival compared to White patients. Further analyses of the individual SGCA histological subtypes identified poorer disease-specific survival for Black compared to White patients with mucoepidermoid and squamous cell carcinomas as the source of the overall poorer disease-specific survival for Black compared to White patients with SGCA. Less surgical treatment for Black compared to White patients was a significant source of the survival disparity for squamous cell SGCA, but not for mucoepidermoid SGCA. Conclusions and Relevance This is the largest study to date to explore racial and ethnic disparities in SGCA survival. Our results show that for patients diagnosed with SGCA, Black race is a risk factor for poorer disease-specific survival for those with mucoepidermoid or squamous cell carcinoma, while Hispanic ethnicity has no effect on disease-specific survival for any SGCA histology. Differences in treatment regimens between Black and White patients play a significant rol...

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Prognostic Factors Depicting Disease-Specific Survival in Parotid-Gland Tumors

Cited by 50 publications

References 17 publications

Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Racial and Ethnic Disparities in Salivary Gland Cancer Survival

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