Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

Cederblad, Lena; Johansson, Silvia; Enblad, Gunilla; Engström, Mats; Blomquist, Erik

doi:10.1080/02841860802680419

Cited by 34 publications

(39 citation statements)

References 20 publications

(40 reference statements)

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“…In the present study, the mean and median ages were 63 and 65.5 years, respectively. The median age of the patients is higher than in most studies, in which it ranges between 50 and 61 years 3,31,36 (except in a study by CEDERBLAD et al 6 in which the median age was the same as in the present study). The present data show a better survival amongst younger patients, possibly related to a greater proportion of low-grade tumours in the younger population, a finding also reported by others 5 .…”

Section: Discussioncontrasting

confidence: 73%

See 1 more Smart Citation

Carcinoma of the parotid gland: developing prognostic indices

Lequerica-Fernández

Peña

Villalaín

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Section: Discussioncontrasting

confidence: 73%

“…Similarly, and in keeping with the findings by SPIRO et al 25 , WAHLBERG et al 36 , and SPITZ and BATSAKIS 28 , relative survival seems to be better in women. In other studies 6 , gender had no impact on survival. In various studies 3,5,6,31 tumour size, grade of malignancy and tumour extension are major predictors for survival.…”

Section: Discussionmentioning

confidence: 91%

Carcinoma of the parotid gland: developing prognostic indices

Lequerica-Fernández

Peña

Villalaín

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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“…Nevertheless, most PGC are diagnosed comparatively early due to their location, and thus T1/2 tumors form a considerably amount of all PGC. According to literature, the incidence of T1/2 tumors is up to 44% of all PGC [9,15,16]. Taking into account these typical problems of a rare disease, the aim of this study was to assess the occurrence of lymph node metastasis in series of 70 patients treated for resectable early-stage PGC and evaluate the results with regard to the surgical management of PGC.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Stenner

Molls

Lüers

et al. 2011

Eur Arch Otorhinolaryngol

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Lymph node metastasis is one of the most important factors in therapy and prognosis for patients with parotid gland cancer. Nevertheless, the extent of the primary tumor resection and the necessity of a neck dissection still is a common issue. Since little is known about lymph node metastasis in early-stage parotid gland cancer, the purpose of the present study was to evaluate the occurrence of lymph node metastases in T1 and T2 carcinomas and its impact on local control and survival. We retrospectively analyzed 70 patients with early-stage (T1 and T2) primary parotid gland cancer. All patients were treated with parotidectomy and an ipsilateral neck dissection from 1987 to 2009. Clinicopathological and survival parameters were calculated. The median follow-up time was 51.7 months. A positive pathological lymph node stage (pN+) was found in 21.4% of patients with a significant correlation to the clinical lymph node stage (cN) (p = 0.061). There were no differences in the clinical and histopathological data between pN- and pN+ patients. In 73.3% of pN+ patients, the metastases were located intraparotideal. The incidence of occult metastases (pN+/cN-) was 17.2%. Of all patients with occult metastases, 30.0% had extraparotideal lymphatic spread. A positive lymph node stage significantly indicated a poorer 5-year overall as well as 5-year disease-free survival rate compared to pN- patients (p = 0.048; p = 0.011). We propose total parotidectomy in combination with at least a level II-III selective neck dissection in any case of early-stage parotid gland cancer.

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“…We report an overall recurrence rate across all histological subtypes of 4%, while historical series over several decades have reported rates around 25% with a range of 14-40%. [4][5][6]12,26 However, we would accept that the follow-up time for our patients is not sufficient to draw firm conclusions regarding overall survival of the cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery has formed the mainstay of treatment 2,3 and the role of postoperative radiotherapy has been established with a growing scope of application. [4][5][6][7][8][9][10][11][12][13][14][15] as these data accumulate, a wider perspective can be drawn on certain aspects, for example on the prognostic factors in advanced adenocarcinoma. 16 In the vast majority of patients with head and neck cancer, a tissue (cytological or histological) diagnosis has been made before arriving at a definitive management plan.…”

mentioning

confidence: 99%

Parotid cancer treatment with surgery followed by radiotherapy in Oxford over 15 years

Shah

Javed

Alcock

et al. 2011

annals

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INTRODUCTION Primary parotid malignancies represent a rare diagnosis, making high-quality comparative research unfeasible. There is little UK-based evidence to guide practice. A review was therefore undertaken of a large series of patients treated by a multidisciplinary team in a National Health Service tertiary referral centre. PATIENTS AND METHODS Retrospective patient record review at the John Radcliffe Hospital in Oxford identified 401 patients who had undergone parotidectomy between 1995 and 2010, of whom 50 subjects were given a definitive diagnosis of primary parotid malignancy, treated with surgery and postoperative radiotherapy. Case notes, histology and imaging were reviewed by the study team. RESULTS The median follow up for the cohort was 60 months (range: 1-108 months). Facial nerve function was preserved in all patients undergoing partial or total conservative parotidectomy. Although histology showed microscopically close or positive margins in 82% of cases, all patients underwent postoperative radiotherapy and locoregional recurrence was identified in only two (4%) patients. CONCLUSIONS The data presented demonstrate a reasonable and practical multidisciplinary approach to a complex management problem. Facial nerve sparing surgery and postoperative radiotherapy result in good control of locoregional disease.

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Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival

Cited by 34 publications

References 20 publications

Carcinoma of the parotid gland: developing prognostic indices

Carcinoma of the parotid gland: developing prognostic indices

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Parotid cancer treatment with surgery followed by radiotherapy in Oxford over 15 years

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