Prognostic effect of mean platelet volume in patients with coronary artery disease

Sansanayudh, Nakarin; Numthavaj, Pawin; Muntham, Dittapol; Yamwong, Sukit; McEvoy, Mark; Attia, John; Sritara, Piyamitr; Thakkinstian, Ammarin

doi:10.1160/th15-04-0280

Cited by 78 publications

(39 citation statements)

References 67 publications

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“…The strengths of this study are the large number of patients, the well-matched controls, and consideration of comorbidities. Previous studies reported that increased MPV is associated with smoking, obesity, diabetes, coronary artery disease and medication use [26]. Although some studies showed that MPV was higher in patients with thyroid malignancies than in patients with benign thyroid disease and control subjects, these studies included small number of patients and failed to rule out the influence of comorbidities and some drugs.…”

Section: Discussionmentioning

confidence: 99%

Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Yu¹,

Li²,

Yun³

et al. 2017

neo

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Thyroid cancer is the most frequent cancer of the endocrine glands and the fifth most frequent cancer in women. Activated platelets play a crucial role in thrombosis, inflammation, and cancer. Mean platelet volume (MPV) and platelet distribution width (PDW) are early index of platelet activation. The purpose of this study is to investigate platelet indices levels in thyroid cancer. The study enrolled 280 patients with thyroid cancer and 280 control subjects. Patients' characteristics and hematologic tests data were collected at the time of diagnosis. Correlations between platelet indices and clinical characteristics were analyzed. The odds ratios (ORs) and 95% confidence intervals (CIs) for thyroid cancer were calculated using multivariate logistic regression analyses across MPV and PDW quartiles. The patients with thyroid cancer had lower MPV and higher PDW compared with control subjects. MPV was correlated with tumor-nodus-metastases (TNM) stage and lymph node metastasis. Moreover, after adjusting for other risk factors, the prevalence risk of thyroid cancer for the lowest quartile of MPV was 7.242 (4.069-12.887) (P < 0.001) and for the highest quartile of PDW was 6.065 (3.321-11.076) (P < 0.001), respectively. The study showed that the patients with thyroid cancer have lower MPV and higher PDW compared to control subjects. Moreover, MPV and PDW were independently associated with the presence of thyroid cancer. Further studies are needed to evaluate the utility of MPV and PDW as novel diagnostic screening tools for thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Yu¹,

Li²,

Yun³

et al. 2017

neo

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“…Several lines of evidence from the literature suggest that a direct correlation exists between MPV and these traditional cerebrovascular risk factors [55][56][57][58][59][60]. MPV was significantly higher (0.65 fL) in individuals with coronary artery disease and patients with high MPV had 17% higher chance of having cardiovascular events compared to patients with low MPV [61]. Another meta-analysis concluded that MPV was significantly higher in those with acute myocardial infarction than those without acute myocardial infarction [62].…”

Section: Discussionmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

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“…Most of these studies were conducted in patients with ACS. A meta-analysis [26] reported that MPV was higher in patients who developed cardiovascular events than in non-cardiovascular event patients, particularly those with MI and death. MPV may be a predictive factor of future MI or death in patients with ACS.…”

Section: Discussionmentioning

confidence: 99%

Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

Jiang

Song

et al. 2013

Cardiol J.

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Background: Mean platelet volume (MPV) is a marker of platelet size and activity, and is associated with a poor prognosis of cardiovascular disease. Studies have shown a relationship between diabetes mellitus (DM) and MPV. This study examined the relationship between admission MPV and 2-year cardiac mortality in patients with DM and stable coronary artery disease (SCAD) undergoing elective percutaneous coronary intervention (PCI). Methods: A total of 1389 patients were enrolled and divided into two groups according to MPV as follows: lower MPV (n = 908, MPV ≤ 10.9 fL) and higher MPV (n = 481, MPV > 10.9 fL . Receiver operating characteristic analysis showed a good diagnostic value for MPV at predicting long-term cardiac mortality (area under the curve: 0.735, p = 0.01). Elevated MPV was a significant risk factor for 2-year cardiac mortality (hazard ratio: 2.091, p = 0.030) in multivariable Cox regression analysis. Conclusions: Mean platelet volume is a strong, independent prognostic factor in PCI-treated patients with DM and SCAD. (Cardiol J 2019; 26, 2: 138-146)

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Prognostic effect of mean platelet volume in patients with coronary artery disease

Cited by 78 publications

References 67 publications

Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

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