Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Abstract

Thyroid cancer is the most frequent cancer of the endocrine glands and the fifth most frequent cancer in women. Activated platelets play a crucial role in thrombosis, inflammation, and cancer. Mean platelet volume (MPV) and platelet distribution width (PDW) are early index of platelet activation. The purpose of this study is to investigate platelet indices levels in thyroid cancer. The study enrolled 280 patients with thyroid cancer and 280 control subjects. Patients' characteristics and hematologic tests data were collected at the time of diagnosis. Correlations between platelet indices and clinical characteristics were analyzed. The odds ratios (ORs) and 95% confidence intervals (CIs) for thyroid cancer were calculated using multivariate logistic regression analyses across MPV and PDW quartiles. The patients with thyroid cancer had lower MPV and higher PDW compared with control subjects. MPV was correlated with tumor-nodus-metastases (TNM) stage and lymph node metastasis. Moreover, after adjusting for other risk factors, the prevalence risk of thyroid cancer for the lowest quartile of MPV was 7.242 (4.069-12.887) (P < 0.001) and for the highest quartile of PDW was 6.065 (3.321-11.076) (P < 0.001), respectively. The study showed that the patients with thyroid cancer have lower MPV and higher PDW compared to control subjects. Moreover, MPV and PDW were independently associated with the presence of thyroid cancer. Further studies are needed to evaluate the utility of MPV and PDW as novel diagnostic screening tools for thyroid cancer.

Platelet distribution width: a novel prognostic marker in an internal medicine ward

“…Moreover, increased PDW levels were positively correlated with MPV values and inversely correlated with platelet counts. Several of our findings concur with studies of various populations [5][6][7][8][9][10][11][12]. PDW is an indicator of heterogeneity in platelet size.…”

“…Increased PDW values have been reported in patients with diabetes mellitus [5], cancer [6,7], and cardiocerebrovascular and respiratory disorders [8][9][10][11][12]. Moreover, higher PDW levels have recently been reported to be associated with increased morbidity and mortality among patients with critical illness [11,13], coronary artery disease [14][15][16][17], cancer [18][19][20][21], pulmonary embolism [10,22], and chronic obstructive pulmonary disease [23].…”

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

“…The MPV is an important platelet indicator and as a marker of platelet size and activation. High MPV value is explained by a biologic explanation that larger platelets are more active in metabolic and enzymatic manner and tend to aggregate, resulting in thrombus or endothelial dysfunction than smaller platelets, as more and more research has been found that MPV is associated with prehypertension and hypertension (Varol et al ., ), type 2 diabetes (Chen et al ., ), familial hypercholesterolemia (Icli et al ., ), cancers (Kemal et al ., ; Kumagai et al ., ; Li et al ., ; Yu et al ., ), and many vascular diseases. Briefly, many studies have found that MPV associate with many vascular complications by means of endothelial damage and thrombosis.…”

A cross sectional study of neutrophil to lymphocyte ratio in patients with benign paroxysmal positional vertigo

“…Neutrophils and other immune system cells secrete tumor growthpromoting factors, such as vascular endothelial growth factor, hepatocyte growth factor, interleukin 6, and interleukin 8, and the growth of tumor cells is stimulated. Therefore, increased NLR and interleukin levels are accompanied by peritumoral macrophage infiltration and this indicates a poor prognosis [18].…”