Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

Abstract

Background: Mean platelet volume (MPV) is a marker of platelet size and activity, and is associated with a poor prognosis of cardiovascular disease. Studies have shown a relationship between diabetes mellitus (DM) and MPV. This study examined the relationship between admission MPV and 2-year cardiac mortality in patients with DM and stable coronary artery disease (SCAD) undergoing elective percutaneous coronary intervention (PCI). Methods: A total of 1389 patients were enrolled and divided into two groups according to MPV as follows: lower MPV (n = 908, MPV ≤ 10.9 fL) and higher MPV (n = 481, MPV > 10.9 fL . Receiver operating characteristic analysis showed a good diagnostic value for MPV at predicting long-term cardiac mortality (area under the curve: 0.735, p = 0.01). Elevated MPV was a significant risk factor for 2-year cardiac mortality (hazard ratio: 2.091, p = 0.030) in multivariable Cox regression analysis. Conclusions: Mean platelet volume is a strong, independent prognostic factor in PCI-treated patients with DM and SCAD. (Cardiol J 2019; 26, 2: 138-146)

Effects of dapagliflozin vs vildagliptin on cardiometabolic parameters in diabetic patients with coronary artery disease: a randomised study

“…The mean platelet volume is a marker of platelet reactivity and associated with glycaemic level in diabetic patients. Similar to hs‐TnT, the mean platelet volume is also associated with cardiovascular pathologies including atherosclerotic cardiovascular disease, HF and mortality . Our results showed that patients receiving vildagliptin had a significant increase in the mean platelet volume, while those receiving dapagliflozin had a stable mean platelet volume.…”

Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review

“…3). 4,[53][54][55][56] Of these, one was rated good and four were rated fair. Publication year ranged from 2013 to 2019.…”

“…Five studies presented categorical analyses, comparing high MPV to low MPV. 4,[53][54][55][56] For these studies, the adjusted ORs ranged from 1.10 (95% CI: 0.69-1.77) to 11.36 (95% CI: 2.48-51.99). Two studies reported adjusted HRs of 1.43 (95% CI: 1.10-1.86) and 2.09 (95% CI: 1.08-4.07).…”

“…Two studies reported adjusted HRs of 1.43 (95% CI: 1.10-1.86) and 2.09 (95% CI: 1.08-4.07). 4,56 One study, including 2,539 patients, did not find an association (OR: 1.10 [95% CI: 0.69-1.77]). 54 In three studies, MPV was analyzed as a continuous variable and the effect estimates were as follows: adjusted OR ¼ 1.89 (95% CI: 1.04-3.44), adjusted HR ¼ 1.16 (95% CI: 1.04-1.30), and adjusted HR ¼ 5.77 (95% CI: 1.28-25.98).…”

“…54 In three studies, MPV was analyzed as a continuous variable and the effect estimates were as follows: adjusted OR ¼ 1.89 (95% CI: 1.04-3.44), adjusted HR ¼ 1.16 (95% CI: 1.04-1.30), and adjusted HR ¼ 5.77 (95% CI: 1.28-25.98). 4,55,56 MPV in Mixed Populations of ACS and Stable CAD Six studies investigated the prognostic role of MPV in a population comprising patients undergoing elective or urgent PCI for ACS and stable CAD (►Table 3 and ►Fig. 4).…”