Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study

Nayak, Sunil; Ochalski, Melanie E.; Fu, Bo; Wakim, Kathryn-Mary; Chu, Tian Jao; Dong, Xinxin; Wakim, Alain

doi:10.1016/j.fertnstert.2013.11.022

Cited by 21 publications

(19 citation statements)

References 41 publications

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“…However, to date, only a small number of studies have focused on the P4 level in serum after hCG injection26. It has been shown that elevated P4 on OPU day is associated with significantly lower implantation and ongoing pregnancy rates27. To provide more clinically useful information on whether embryos should be frozen and transferred, P4 level measurement should be considered on hCG day and also the day after hCG administration26.…”

Section: Discussionmentioning

confidence: 99%

Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

Fang

Zhang

et al. 2016

Sci Rep

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Growth differentiation factor-8 (GDF-8) is found in the human serum, follicular fluid and granulosa cells. Our previous studies have shown that the human cumulus expansion and steroidogenesis can be regulated by GDF-8. However, thus far, the expression profile of GDF-8 in serum and whether the level of serum GDF-8 influences pregnancy results for patients treated with in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) is totally unknown. In this study, we showed that GDF-8 had a dynamic trend during controlled ovarian hyperstimulation (COH) procedure. On human chorionic gonadotropin (hCG) administration day, patients with a GDF-8 level higher than 4.7 ng/ml had lower progesterone levels and a higher pregnancy rate. From hCG day to oocyte pick-up day, patients with a GDF-8 decrease greater than 1.3 ng/ml had a higher progesterone increase and a higher pregnancy rate. Importantly, the levels of GDF-8 were negatively correlated with progesterone levels. Our findings provide evidences that GDF-8 plays an important role in ensuring successful pregnancy by regulating progesterone levels.

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Section: Discussionmentioning

confidence: 99%

Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

Fang

Zhang

et al. 2016

Sci Rep

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“…30 As an elevated P does not appear to affect the number of mature oocytes retrieved or fertilization rates, it effects the implantation rate. 31 Despite the recent report of successful oocyte retrieval using r-hCG in a similar case, there is a lack of theoretical rationale to explain how this approach would work differently with the already-proven bioavailability of u-hCG administered. 32 By increasing the time of exposure to β-hCG, no consistent differences in oocyte yield, maturity, fertilization, or embryo quality were detected.…”

Section: Preventionmentioning

confidence: 99%

Empty Follicular Syndrome: Understanding Controversial Entity

Choudhary¹

2017

Journal of South Asian Federation of Obstetrics and Gynaecology

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Empty follicular syndrome (EFS) is defined as the failure to retrieve oocytes from mature ovarian follicles after controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). There are two types of EFS-genuine and false EFS. In genuine EFS, there is failure to retrieve oocytes from mature ovarian follicles after COH for IVF after apparently normal follicular development and steroidogenesis in the presence of optimum β-human chorionic gonadotropin (hCG) levels, whereas in false EFS, there is failure to retrieve oocytes in the presence of low β-hCG levels. Whatever may be the cause of EFS, these patients should be counseled regarding its possibility of recurrence and future poor prognosis. However, different IVF treatment methods in subsequent cycles could modulate the response with successful oocyte recovery in such cases.

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“…Oocytes were fertilized in vitro by conventional IVF or ICSI, and ET occurred 3 days afterwards. All embryos transferred were 6 cells or greater and were of good quality (2) .…”

Section: In Vitro Fertilization-embryo Transfer (Ivf-et)mentioning

confidence: 99%

“…Furthermore AZEM et al (30) found an inverse relationship between P level and pregnancy rate. Later on, Nayak et al (2) showed that elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates.…”

Section: Such Finding Coincided With Silverberg Et Almentioning

confidence: 99%

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Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

2017

Evidence Based Women's Health Journal

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Background: Hormone levels (progesterone "P" and luteinizing hormone "LH) are vitally important to the proper functioning of the female reproductive cycle and together with Ultrasound assessment of endometrial receptivity may predict success of in vitro fertilization/ intracytoplasmatic sperm injection (IVF/ICSI). Objective: to study the effects of serum P and LH levels together with Ultrasound assessment of endometrial receptivity at the day of human chorionic gonadotrophin administration on fertilization and pregnancy rates. Patients and Methods: Thirty patients age ranged 22-38 years underwent ovarian stimulation using a gonadotrophinreleasing hormone (GnRH) agonist for pituitary down-regulation, and then ovarian hyperstimulation was initiated with highly purified human menopausal gonadotrophin (HMG). Final oocyte maturation was triggered 36 hours after human chorionic gonadotrophin (hCG) injection. On the day of hCG administration (Day 0), serum progesterone, LH levels together with Ultrasound assessment of endometrial receptivity (thickness, morphology and the spiral artery resistance index "RI") were evaluated. Fertilization and pregnancy rates were recorded. Results: There was no significant difference between the pregnant and non pregnant women, in respect to age. The pregnancy rate was not affected by the serum LH level but was only 18.75% in cycles in which serum P was more than 1.2 ng/ml on day 0, which was significantly lower than that in cycles in which serum P was less than 1.2 ng/ml on day 0 (64.28%) (P = 0.001). The fertilization rate was lower in the cycles with higher levels of serum P and/or LH than in cycles in which serum P was less than 1.2 ng/ml and serum LH was normal (51.66 vs. 68.85%). Failed cases had altered endometrium and a higher spiral artery RI (resistance index), meaning lower peri-implantation blood flow. Conclusion: This study concluded that the progesterone levels on the day of hCG administration (Day 0) can affect the success of in vitro fertilization, as higher progesterone levels were associated with lower rates of pregnancy and fertilization. Increase serum P level caused advanced endometrial maturation and impaired endometrial receptivity to embryo implantation. The embryo transfer (ET) in such cases can be canceled and freezing all embryos for future transfer must be considered, to increase acceptance of the endometrium and thus increase the success rate.

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Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study

Cited by 21 publications

References 41 publications

Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

Empty Follicular Syndrome: Understanding Controversial Entity

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

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