Progesterone and Aldosterone Secretion Rates in Pregnancy

Solomon, Sidney; Watanabe, Morihiro; Dominguez, Oscar V.; Ma, Gray; Meeker, Chris; Sims, Ethan A. H.

doi:10.1159/000390769

Cited by 2 publications

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“…This difference may represent a genuine increase in production of progesterone by the placenta with increasing gestation. In Experiment 1 the calculated daily production of 31 mg progesterone/day into the maternal circulation falls within the range calculated at this stage of pregnancy (Zander & von Münstermann, 1954;Ejarque & Bengtsson, 1962;Solomon, Watanabe, Domínguez, Gray, Meeker & Sims, 1964). Fig.…”

Section: Discussionsupporting

confidence: 76%

Formation of Progesterone and Pregnenolone From [4-14c]cholesterol by the Intact Mid-Term Human Foeto—placental Unit Perfused in Vitro

Dt¹,

Cockburn²,

Galbraith³

et al. 1973

Journal of Endocrinology

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SUMMARY A system for perfusing in vitro the mid-term human pregnant uterus containing the entire foeto-placental unit is described. After termination by hysterectomy, circulation was established within 15 min by cannulation of the uterine arteries. In two experiments the foetal heart rate remained reasonably steady during the perfusion (107 and 127 min respectively). The rates of secretion of pregnenolone and progesterone into the uterine veins were within the range calculated for the period of gestation. Conversion of [4-14C]cholesterol to pregnenolone and progesterone was observed in both experiments although in neither could it account for the total secretion of progesterone.

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Section: Discussionsupporting

confidence: 76%