Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

Boonyarattanasoonthorn, Tussapon; Elewa, Yaser Hosny Ali; Tag-EL-Din-Hassan, Hassan T.; Morimatsu, Masami; Agui, Takashi

doi:10.1016/j.meegid.2019.04.019

Cited by 9 publications

(5 citation statements)

References 46 publications

(60 reference statements)

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“…Through its action as a signaling molecule, IL-8 fosters the recruitment of neutrophils to the lung epithelium. These findings are convergent with the well-established neutrophil accumulation in lungs during infections by respiratory mycoplasmas ( 85 – 89 ). Neutrophils counteract the infection through phagocytosis and/or the release of neutrophil extracellular traps (NETs) ( 90 ).…”

Section: Putative Functions Of Mycoplasma Immunoglobulin-blocking Proteinssupporting

confidence: 86%

Beware of Mycoplasma Anti-immunoglobulin Strategies

Arfi

Lartigue

Sirand‐Pugnet

et al. 2021

mBio

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Section: Putative Functions Of Mycoplasma Immunoglobulin-blocking Proteinssupporting

confidence: 86%

Beware of Mycoplasma Anti-immunoglobulin Strategies

Arfi

Lartigue

Sirand‐Pugnet

et al. 2021

mBio

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“…Despite the presence of several reports concerning the role of several immune cells (T-and B-lymphocytes and macrophages) [10][11][12][13] and the lung NHC [7] in the pathogenesis of lung asthma progression, the possible source of the recruitment of immune cells in the asthmatic mouse model is still poorly understood. Currently, we revealed the correlation between the development of MFALCs and pathogenesis of several lung injuries and immune cell infiltration into the lung using several mouse models, including genetic autoimmune mouse model [21,29] with the septic condition such as bleomycin-induced pneumonitis mouse model [22], the aseptic condition such as Mycoplasma pulmonis infection in mice [30], and metabolic disorders such as streptozotocininduced diabetic mouse model [31]. However, the functional attribution of MFALCs in either asthma progression or recovery is not yet clarified.…”

Section: Discussionmentioning

confidence: 99%

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Elewa

Elwakil

Ichii

et al. 2021

IJMS

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Recently, we clarified the function of mediastinal fat-associated lymphoid clusters (MFALCs) in the progression of several respiratory diseases. However, their role has not yet been identified in the lung asthmatic condition. Hence, we compared the immune cells in lung and MFALCs of C57BL/6N mice on days 3 and 7 following intranasal instillation of either papain (papain group “PG”) or phosphate buffer saline (PBS) (vehicle group “VG”). The PG showed significantly prominent MFALCs, numerous goblet cells (GCs), and higher index ratios of different immune cells (macrophages, natural helper cells (NHC), B- and T-lymphocytes) within the MFALCs and lung than in the VG on both days 3 and 7. Interestingly, a tendency of decreased size of MFALCs and a significant reduction in the number of GCs and immune cells were observed within the MFALCs and lung in the PG on day 7 than on day 3. Furthermore, the quantitative parameters of these immune cells in MFALCs were significantly and positively correlated with the size of MFALCs and immune cells in the lung. This suggested that the possible crosstalk between immune cells within MFALCs and the lung could play a critical role in the progression and recovery of the acute inflammatory lung asthma.

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“…Previously, we reported novel lymphoid clusters associating with the mediastinal fat tissue of healthy mice strains (3). Furthermore, we revealed their role in the development of numerous respiratory diseases including septic condition such as bleomycin induced pneumonitis (5), as well as aseptic infection with Mycoplasma pulmonis (8). Interestingly, in birds more close contact of air carrying infectious agent could lead to the development of air sacculitis due to its functional attribution in allowing continuous flow of the air in one way direction.…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, the role of FALCs in controlling the Nippostrongylus brasiliensis helminth infection in mice has been revealed via B-1 B cell proliferation and promotes goblet cell hyperplasia (1,7). Furthermore, our previous research revealed that mice strain difference in the susceptibility to Mycoplasma pulmonis infection correlates with degree of FALCs development (8).…”

Section: Chicken Air Sacs and Mesentery: A Histomorphometrical And Im...mentioning

confidence: 99%

Chicken Air Sacs and Mesentery: A Histomorphometrical and Immunological Study

Elewa

Islam²,

Mohamed³

2023

SVR

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Fat-associated lymphoid clusters (FALCs) are novel lymphoid tissues that have been reported in the mesenteric and mediastinal fat tissue of mouse and human. It plays role in the progression of respiratory and intestinal inflammation and parasitic infestations. However, their occurrence in the chicken air sacs and mesenteric adipose tissue has not yet been identified. Here we investigated the occurrence and distribution of FALCs in the air sacs (cervical, clavicular, thoracic, and abdominal) and mesenteric adipose tissue of healthy chicken. The latter air sacs and mesentery were immediately harvested after anesthesia and cutting the chicken heads then fixed in 4% paraformaldehyde fixative solution for histopathological examination. The degree of FALCs development among different specimens was measured and statistically analyzed. Our results revealed lymphoid clusters associating with the adipose tissues in mesentery, and air sacs (clavicular, thoracic, and abdominal), but not the cervical one. Interestingly, the thoracic air sacs showed significant higher FALCs size in comparison to that of other air sac types and the mesentery. Our findings suggested other possible immunological role of the air sacs and mesentery that could have impact on the progression of air sacculitis and mesenteritis- associate diseases. However, further investigations are required for clarification of air sacs and mesenteric FALCs in the progressions of respiratory and digestive tract diseases.

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Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

Cited by 9 publications

References 46 publications

Beware of Mycoplasma Anti-immunoglobulin Strategies

Beware of Mycoplasma Anti-immunoglobulin Strategies

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Chicken Air Sacs and Mesentery: A Histomorphometrical and Immunological Study

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