Profile of fasting blood glucose in obese children with insulin resistance

Yuri,; Pangestu, Yose M.; Pateda, Vivekenanda; Tirtamulya, Kristellina; Warouw, Sarah M.

doi:10.1186/1687-9856-2013-s1-p100

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“…Also, the risk of having impaired plasma glucose is higher in obese children from Sweden compared to obese children in Germany [ 54 ]. Another study conducted on 54 obese children confirmed that obese children with insulin resistance have higher blood sugar level compared to those obese children without insulin resistance [ 55 ]. Interestingly, it has been suggested that the risk of having impaired glucose tolerance is higher in obese children who have high fasting blood glucose level, but still in the range of the reference values [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance

Kostovski

Simeonovski

Mironska

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:In the past several decades, the increasing frequency of overweight and obese children and adolescents in the world has become a public health problem. It has contributed significantly to the already high tide of diabetes, cardiovascular and cerebrovascular diseases.AIM:To investigate the frequency of insulin resistance and to evaluate the metabolic profile of insulin resistant and non-insulin resistant obese children and adolescents.SUBJECTS AND METHODS:The study included 96 (45 boys, 51 girls) obese children and adolescents aged 4-17 years old (10.50 ± 2.87 years). Only participants with Body Mass Index ≥ 95 percentile were included. We analysed sera for fasting insulin levels (FI), fasting serum triglycerides (TG), total serum cholesterol (TC), fasting plasma glucose (FPG) and plasma glucose 2 hours after the performance of the oral glucose tolerance test (2-h G). Homeostatic model assessment for insulin resistance (HOMA-IR) index was calculated as fasting insulin concentration (microunits per millilitre) x fasting glucose concentration (millimolar)/22.5. The value of HOMA-IR above 3.16 was used as a cut-off value for both genders.RESULTS:Insulin resistance was determined in 58.33% of study participants. Insulin resistant participants had significantly higher level of 2-h G (p = 0.02), FI level (p = 0.000) as well as TG levels (p = 0.01), compared to non-insulin resistant group. Strikingly, 70.73% of the pubertal adolescents were insulin resistant in comparison to 49.09% of the preadolescents (p = 0.03). Significantly higher percentage of insulin-resistant participants were girls (p = 0.009). Moreover, a higher percentage of the girls (70.59%) than boys (44.44%) had HOMA-IR above 3.16 and had elevated FI levels (70.59% vs 48.89%). The difference in the frequency of insulin resistance among obese versus severely obese children and adolescents was not significant (p = 0.73, p > 0.05). Our study results also showed positive, but weak, correlation of HOMA-IR with age, FPG, TG and BMI of the participants (p < 0.05).CONCLUSION:Higher percentage of insulin-resistant participants was of female gender and was adolescents. In general, insulin resistant obese children and adolescents tend to have a worse metabolic profile in comparison to individuals without insulin resistance. It is of note that the highest insulin resistance was also linked with the highest concentrations of triglycerides.

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Section: Discussionmentioning

confidence: 99%