Profile of Bacteraemia and Fungemia in HIV/AIDS Patients with Sepsis

Abstract

Blood flow infections in HIV/AIDS patients are a major cause of illness and death. Diagnosis of bloodstream infections is mainly established through blood cultures. This study aimed to determine the profile of bacteremia and fungemia in HIV / AIDS patients with sepsis treated at the Intermediate and Infectious Care Unit of Dr. Soetomo General Hospital, Surabaya. Aerobic and fungal blood cultures were examined for HIV/AIDS patients with sepsis using an aerobic bactec bottle and bacterial identification using a BD Phoenix semiautomatic machine, with the identification of fungus by using the semiautomatic machine Vitek 2 compact (BioMerieux). Out of the 51 patients with sepsis which underwent blood cultures, a positive blood culture was obtained in eight patients (16% proportion). Bacteria obtained included Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Klebsiella oxytoca, Acinetobacter baumannii, Non-Typhoid Salmonella, and Micrococcus luteus. The fungus was Cryptococcus spp.

Multiple pathogens contribute to human immunodeficiency virus-related sepsis in addition to Mycobacterium tuberculosis: A prospective cohort in Tanzania

“…As a consequence of altered immune mechanisms in advanced PLHIV, all these microbes may be involved either as a single infection in sepsis or in a polymicrobial pattern. [ 12 – 15 ]…”