Profil Klinis Karsinoma Nasofaring di Departemen THTKL  RSUP Dr. Mohammad Hoesin Palembang  Tahun 2014-2015

Dawolo, Abdiaman Putra; Utama, Denny Satria; Kasim, Bahrun Indawan

doi:10.32539/mks.v49i1.8318

Cited by 4 publications

(10 citation statements)

References 3 publications

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“…This study found that most patients (42.8%) were diagnosed with stage IVB, followed by stage IVA (19.9%). Similar results were shown in studies by Sekarutami et al [26] and Sriwijaya et al [27] which stated most patients were diagnosed in stage IV. This is mainly caused by the delayed diagnosis because doctors and patients do not pay attention to early signs of this malignancy such as hearing defect until there is an enlarged neck lymph node which is a sign of an advanced stage of NPC [11,12].…”

Section: N D I R a M E I D I N A N A F I S A E T A L Nasopharyngeal ...supporting

confidence: 90%

Profile of Nasopharyngeal Cancer Patients who Underwent Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung

Nafisa

Utama

Sunardi

et al. 2022

Indonesian Journal of Cancer

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Background: Nasopharyngeal cancer (NPC) is a malignant epithelial tumor located in the nasopharynx and is the most common head and neck malignancy. This study aimed to find and describe the profile of NPC patients who undergo radiotherapy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study was a descriptive study conducted at the Department of Radiology of Dr. Hasan Sadikin General Hospital, Bandung. This study employed a total sampling method and was done by observing patients’ status/medical records from January 1, 2018, to December 31, 2019, which was registered based on the Hospital-Based Cancer Registry (HBCR). The inclusion criteria were all patients diagnosed with NPC and undergone radiotherapy.Results: There were 274 records (19.74%) included as NPC from 1,388 records. This cancer was more frequent in men (70.4%), in the age group of 45–54 years (35.0%), non-active smokers (58.8%), entrepreneurs (23.0%), and those who came from West Priangan (36.1%). The most common chief complaint was an enlargement of neck lymph nodes (55.1%) at stage IVB (42.8%). Histopathological findings were dominated by undifferentiated squamous cell carcinoma (WHO III) (74.4%). Most of the patients were treated with chemoradiation (64.3%).Conclusions: NPC could happen to anyone with different background. This study found it was more frequent in men than women (2.3:1), in the fourth and fifth decade of life, in entrepreneurs followed by housewives, and even in non-active smokers. It also could happen in children to the elderly. Most patients came with an enlargement of neck lymph nodes as their chief complaint in the advanced stage and need chemoradiation as their treatment.

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Section: N D I R a M E I D I N A N A F I S A E T A L Nasopharyngeal ...supporting

confidence: 90%

Profile of Nasopharyngeal Cancer Patients who Underwent Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung

Nafisa

Utama

Sunardi

et al. 2022

Indonesian Journal of Cancer

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“…The results of this study are in line with research conducted by Dawolo, which stated that most nasopharyngeal cancer patients were in the age group 46-55 years (30.91%). 22 The similar aspect was also explained by Barns that in areas with a high risk of nasopharyngeal cancer, the incidence increased after the age of 30 and peaked at the age of 40-60 years. 23 Furthermore, the results of this study are in accordance with the study conducted by Fatusi et al explaining that NPC patients from various countries can suffer from ages from 4 to 91 years, with a peak incidence at 50 to 60 years in the Chinese population.…”

Section: Patient Age Distributionsupporting

confidence: 54%

Effect of LMP-1 and mutant p53 on the Prognosis of Undifferentiated Type of Nasopharyngeal Carcinoma

Atikah

Sadhana

Miranti

et al. 2022

MMJKK

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Undifferentiated carcinoma is a subtype of NPC with a higher EBV antibody titer than healthy people. The carcinogenic effect of EBV involves LMP-1 associated with poor prognosis, and mutant p53 predicts tumor recurrence. This study aims to assess the effect of LMP-1 and mutant p53 on the prognosis of NPC patients. 40 paraffin blocks were stained with LMP-1 and p53 mutant. LMP-1 was positive when the cytoplasm and tumor cell membranes were brown, and mutant p53 was positive for the brown tumor cell nucleus. Pearson correlation test was performed. Most respondents were in the age group 40 years, males, regional lymph node involvement (N) in group N1, and no metastasis (M). The expression levels of LMP-1 and mutant p53 were strongly positive. The study showed the correlation between LMP-1 with age (p 0.327), gender (p 0.599), category N (p 0.512), category M (p 0.019) and the correlation between mutant p53 with age (p 0.329), gender (p 0.981), category N (p 0.013), category M (p 0.705). LMP-1 expression with mutant p53 (p 0.760). It can be concluded that LMP-1 and mutant p53 could be used as prognostic factors in NPC patients.

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“…Hal tersebut terjadi karena gaya hidup laki-laki berbeda dengan perempuan seperti kebiasaan merokok dimana jumlah perokok pada laki-laki lebih tinggi daripada perempuan. Selain itu, Laki-laki juga memiliki pekerjaan yang cenderung mengakibakan KNF dikarenakan terpaparnya bahan kimia (Dawolo et al, 2019).…”

Section: Jenis Kelaminunclassified

“…Hasil sejalan dengan penelitian Dawolo A.P dkk (2017) menunjukkan paling tinggi sebanyak 30,91% terdapat pada kelompok usia 46-55 tahun peningkatan insidensi KNF pada umur 20 tahun dan puncaknya pada 40-50 tahun, sedangkan di daerah yang beresiko rendah ditemukan peningkatan insidensi KNF pada umur 15 tahun dan puncaknya pada umur 50-60 tahun. Hal tersebut terjadi karena faktor resiko seperti kebiasaan merokok dan konsumsi ikan asin sejak usia dini, sehingga KNF dapat muncul ketika seseorang telah mencapai usia produktif, karena mulai dari paparan pertama bahan karsinogen sampai timbulnya kanker memerlukan waktu yang lama (Dawolo et al, 2019).…”

Section: Usiaunclassified

“…Hasil penelitian sejalan dengan penelitian Diniati A (2017), bahwa mayoritas responden menunjukkan hasil PA karsinoma nasofaring (+) (A, 2016). Hasil serupa dengan penelitian Dawolo A.P dkk (2017) menunjukkan responden mayoritas dengan gambaran PA (+) (Dawolo et al, 2019).…”

Section: Diketahui Distribusi Frekuensi Pasien Karsinoma Nasofaring DI Rsud Abdul Moeloek Bandar Lampung Tahun 2020unclassified

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Konsumsi Ikan Asin dan Daging Asap dengan Kejadian Karsinoma Nasofaring

Kasim

Tan’im²,

Pebriyani

et al. 2020

jiskh

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Latar Belakang: Faktor dominan timbulnya karsinoma nasofaring adalah dari Ras Mongoloid dengan kebiasaan mengkonsumsi ikan asin dan makanan yang diawetkan salah satunya daging asap. Tujuan : Untuk mengetahui hubungan antara konsumsi ikan asin dan daging asap dengan kejadian karsinoma nasofaring. Metode : Penelitian ini metode observasional analitik dan menggunakan pendekatan cross sectional. Sampel pada penelitian ini adalah seluruh pasien yang didiagnosis karsinoma nasofaring yang tercatat dalam Rekam yang sesuai kriteria inklusi berjumlah 52 orang. Teknik pengambilan sampel pada penelitian ini menggunakan Teknik total sampling. Analisis data menggunakan analisis univariat dan analisis bivariat menggunakan uji chi-square. Hasil : dari 52 responden diketahui distribusi frekuensi karakteristik pasien karsinoma nasofaring mayoritas berjenis kelamin laki-laki sebesar 64,4%, mayoritas tertinggi pada kelompok usia 46-55 tahun sebesar 32,7%, pekerjaan terbanyak adalah petani sebesar 32,7%. Diketahui terdapat hubungan yang signifikan antara konsumsi ikan asin dengan kejadian karsinoma nasofaring (p:0,003) dan terdapat hubungan yang signifikan antara konsumsi daging asap dengan kejadian karsinoma nasofaring (p:0,002). Kesimpulan: Terdapat hubungan yang signifikan antara konsumsi ikan dan konsumsi daging asap dengan kejadian karsinoma nasofaring

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Profil Klinis Karsinoma Nasofaring di Departemen THTKL RSUP Dr. Mohammad Hoesin Palembang Tahun 2014-2015

Cited by 4 publications

References 3 publications

Profile of Nasopharyngeal Cancer Patients who Underwent Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung

Profile of Nasopharyngeal Cancer Patients who Underwent Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung

Effect of LMP-1 and mutant p53 on the Prognosis of Undifferentiated Type of Nasopharyngeal Carcinoma

Konsumsi Ikan Asin dan Daging Asap dengan Kejadian Karsinoma Nasofaring

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