Production ofL-lactic acid byLactobacillus delbrueckii in chemostat culture using an ion exchange resins system

Monteagudo, J.M.; Aldavero, María

doi:10.1002/(sici)1097-4660(199907)74:7<627::aid-jctb84>3.0.co;2-k

Cited by 33 publications

(6 citation statements)

References 16 publications

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“…The high cost of the equipment and the low capacity of the resins can limit the applicability of the method. Other attempts to reduce the end-product inhibition were made by employing electrodialysis [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

(Liquid+liquid) equilibria of (water+lactic acid+alcohol) ternary systems

Şahın

Kırbaşlar

Bilgin

2009

The Journal of Chemical Thermodynamics

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Section: Introductionmentioning

confidence: 99%

(Liquid+liquid) equilibria of (water+lactic acid+alcohol) ternary systems

Şahın

Kırbaşlar

Bilgin

2009

The Journal of Chemical Thermodynamics

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“…Fermentation technology for the production of organic acids in particular has been known for more than a century and acids have been produced in the form of aqueous solutions. Several separation methods such as liquid extraction [1][2][3], ultra filtration [4], reverse osmosis [5], electrodialysis [4,[6][7][8], direct distillation [9], liquid surfactant membrane extraction [10], anion exchange [11,12], precipitation, and adsorption [13,14], etc., have been employed to remove carboxylic acids. In general, most carboxylic acids, except for acetic acid, are non-volatile; therefore, distillation is not a useful recovery process.…”

Section: Introductionmentioning

confidence: 99%

Intensification of Nicotinic Acid Separation using Organophosphorous Solvating Extractants by Reactive Extraction

2008

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Nicotinic acid (3-pyridine carboxylic acid) is widely used in food, pharmaceutical, and biochemical industries. Compared to chemical methods, enzymatic conversion of 3-cyanopyridine is an advantageous alternative for the production of nicotinic acid. This study is aimed to intensify the recovery of nicotinic acid using reactive extraction with organophosphorus solvating extractants such as tri-noctyl phosphine oxide (TOPO) and tri-n-butyl phosphate (TBP). The distribution of nicotinic acid between water and phosphorus-based solvents dissolved in various diluents and the comparison of extraction efficiency with pure diluents are studied at isothermal conditions. Pure diluents are not found to be good extracting agents and the maximum distribution coefficient (K D ) obtained with 1-octanol is 0.31. Experimental studies are carried out to investigate the effect of diluent, initial acid concentration, extractant type, and extractant composition on the degree of extraction. The maximum recovery of nicotinic acid is obtained by dissolving TOPO in MIBK at an initial nicotinic acid concentration of 0.10 kmol/m 3 . Solvation numbers and extraction equilibrium are also estimated with both TBP and TOPO.

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“…The recovery of lactic acid obtained by fermentation media or from synthetic solutions has been studied by different authors over the years [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. In these studies, the most commonly used resin was Amberlite IRA 400 [16][17][18]23,27,28].…”

Section: Introductionmentioning

confidence: 99%

Ion-Exchange Technology for Lactic Acid Recovery in Downstream Processing: Equilibrium and Kinetic Parameters

Vecino

Reig

Valderrama

et al. 2021

Water

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The downstream processing for the separation and purification of lactic acid is a hot research area in the bio-refinery field due to its continuous growing market in different sectors, such as the food, cosmetic and pharmaceutical sectors. In this work, the use of ion-exchange technology for lactic acid recovery is proposed. For that, four anion exchange resins with different polymer structures and functional groups were tested (A100, MN100, A200E and MP64). The sorption process was optimized by the Box–Behnken factorial design, and the experimental data obtained in the sorption process were analyzed by using the response surface methodology and fitted at different isotherms and kinetics models. Moreover, regenerant type, contact time and solid/liquid ratio were evaluated in the desorption process. Results showed that the best resin for lactic acid removal was A100, at pH = 4, with a resin/lactic acid solution ratio of 0.15 g/mL during a maximum of 1 h, achieving 85% of lactic acid removal. Moreover, equilibrium data sorption of lactic acid onto A100 resin was fitted by a Langmuir isotherm and by a kinetic model of a pseudo-second order. In addition, in the desorption process, it was stablished that a resin/regenerant ratio of 0.15 g/mL during 30 min with 0.1 M of NaOH solution provided the best results (4.45 ± 0.08 mg/g).

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Production ofL-lactic acid byLactobacillus delbrueckii in chemostat culture using an ion exchange resins system

Cited by 33 publications

References 16 publications

(Liquid+liquid) equilibria of (water+lactic acid+alcohol) ternary systems

(Liquid+liquid) equilibria of (water+lactic acid+alcohol) ternary systems

Intensification of Nicotinic Acid Separation using Organophosphorous Solvating Extractants by Reactive Extraction

Ion-Exchange Technology for Lactic Acid Recovery in Downstream Processing: Equilibrium and Kinetic Parameters

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