Production of Vitamin-E Deficiency and Muscular Dystrophy in Pigs

Production of Muscular Dystrophy in Pigs by Feeding Cottonseed Oil

“…The group receiving 5 per cent lard (group 4, experiment III) did not react with MD. This is in accordance with earlier observations (10) . This diet contained approximately the same quantities of PFA and tocopherols as the diet supplemented with 0.5 per cent stripped CSO (group 3, experiment III), where one animal reacted.…”

“…Observations that MD in pigs can be induced by the addition of cod-liver oil (6,10) and corn oil (20, 20a) to the diet support the assumption that PFA are of essential importance in the aetiology of the experimental disease. Cod-liver oil is poor in linoleic acid but contains tetraenoic (arachidonic) acid.…”

“…The relation between plasma-GOT values and the morphological status of the muscles with regard to MD was studied in earlier papers (9,10,15).…”

The Vitamin E-Deficiency Syndrome in Pigs

“…Blaxter & McGill also directed the attention to the association between MD and the muscular damage in the myocardium occurring in "fatal syncope" or "plotzlicher Herztod", earlier described by Hupka ( 1939). Later on, MD in pigs has been produced with diets containing cod liver oil (Lannek et al 1961), lard (Hill & Larsson 1955, maize oil (Thafvelin 1960, Grant 1961 or vitamin Estripped cottonseed oil (Lindberg& Orstadius 1961). Tanhuanpiiii (1965) in his investigation on fatty acid composition of tissue lipids in pigs, produced MD by increasing the amount of dietary C 18: 2 in relation to dietary tocopherol.…”

The role of vitamin E and selenium in the nutrition of the pig

“…Tallan (1955) Other factors that may be involved in vitamin E-selenium deficiencies are polyunsaturated fat, sulfur amino acids, iron injections and synthetic antioxidants. The dystrophogenic property of polyunsaturated fatty acids has been demonstrated experimentally by a number of workers (Obel, 1953;Lannek et al, 1961;Lindberg and Orstadius, 1961;Orstadius, Nordstrom and Lannek, 1963;Tanhuanpaa, 1965). Nutritional muscular dystrophy can be produced experimentally in pigs by feeding grain that has been associated with natural outbreaks (Thafvelin, 1960;Lannek et al, 1960).…”