Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system☆

Chattopadhyay, Pratibhash; Shekunov, Boris Y.; Yim, DaBin; Cipolla, David; Boyd, Brooks; Farr, Stephen J.

doi:10.1016/j.addr.2007.04.010

Cited by 196 publications

(95 citation statements)

References 19 publications

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“…This method has demonstrated a wide range of application in producing pulmonary inhalable formulations. 23,161,162 Supercritical fluid technology can be divided into several classes. The most important two are supercritical antisolvent precipitation (SAS) 163,164 and supercritical fluid extraction of emulsions (SFEE).…”

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

“…163,164 SFEE can provide uniform crystalline drug nanoparticles, composite nanoparticles containing polymeric materials and the drugs, and nanosuspensions. 165,166 For instance, Chattopadhyay and colleagues 23 used a continuous SFEE method to produce nanoparticle suspensions containing one of three lipids (tripalmitin, tristearin, or gelucire 50/13), and one of two model drugs (indomethacin or ketoprofen). The first step of this process was to produce nanoemulsions by mixing organic phase containing lipids, a selected drug and chloroform with aqueous phase containing sodium glycocholate, under high pressure homogenization.…”

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

See 1 more Smart Citation

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

403

269

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Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

403

269

View full text Add to dashboard Cite

“…High-speed stirring mixers [46], [47], [51], high-pressure homogenization [45], [53], [54], and ultrasonication [55][56][57][58] have been used to form fine emulsions for use in the SFEE process. Microfluidization is an additional alternative for preparing submicron emulsions.…”

Section: Emulsion Preparationmentioning

confidence: 99%

“…The antisolvent is first injected into the precipitation vessel through a frit [54] or a nozzle [57] until the desired pressure, temperature, and flow rate are reached and maintained constant. According to Shekunov et al [45], the use of a frit maximizes the mass-transfer efficiency during organic solvent extraction.…”

Section: Sfee Processingmentioning

confidence: 99%

Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Gomes¹,

Santos²,

Meireles³

2012

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This review discusses the recent developments in the application of supercritical fluid technologies for the production of composites or encapsulates of bioactive compounds. Various supercritical particle formation technologies are briefly described, including processes in which the supercritical fluid acts as a solute, solvent, and antisolvent. The main features and mechanisms of antisolvent techniques that contribute to the understanding of the fundamentals of the Supercritical Fluid Extraction of Emulsions (SFEE) process are described. The published literature on SFEE, including the results and perspectives of its application in various industrial fields, are discussed. This article is the first comprehensive review specifically focused on the formation of particles using the SFEE technique.

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“…Although liquid dispersions of SLN can also be converted into dry powders for stable storage by spray-drying or lyophilization, 10,11 suspensions are still preferred due to great ease of preparation and low cost. 12,13 Production cost is an important driver for developing veterinary clinical applications, 14 and SLN suspensions can be produced on a large scale and can be used directly. 15,16 Particle size has become an important developmental consideration in the field of nanobiology, particularly during the development of new drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes

Chen¹,

Wang²,

Lu³

et al. 2014

IJN

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Three tilmicosin-loaded hydrogenated castor oil nanoparticle (TMS-HCO-NP) suspensions of different particle sizes were prepared with different polyvinyl alcohol surfactant concentrations using a hot homogenization and ultrasonic technique. The in vitro release, in vitro antibacterial activity, mammalian cytotoxicity, acute toxicity in mice, and stability study were conducted to evaluate the characteristics of the suspensions. The in vitro tilmicosin release rate, antibacterial activity, mammalian cytotoxicity, acute toxicity in mice, and stability of the suspensions were evaluated. When prepared with polyvinyl alcohol concentrations of 0.2%, 1%, and 5%, the mean diameters of the nanoparticles in the three suspensions were 920±35 nm, 452±10 nm, and 151±4 nm, respectively. The three suspensions displayed biphasic release profiles similar to that of freeze-dried TMS-HCO-NP powders, with the exception of having a faster initial release. Moreover, suspensions of smaller-sized particles showed faster initial release, and lower minimum inhibitory concentrations and minimum bactericidal concentrations. Time-kill curves showed that within 12 hours, the suspension with the 151 nm particles had the most potent bactericidal activity, but later, the suspensions with larger-sized particles showed increased antibacterial activity. None of the three suspensions were cytotoxic at clinical dosage levels. At higher drug concentrations, all three suspensions showed similar concentration-dependent cytotoxicity. The suspension with the smallest-sized particle showed significantly more acute toxicity in mice, perhaps due to faster drug release. All three suspensions exhibited good stability at 4°C and at room temperature for at least 6 months. These results demonstrate that TMS-HCO-NP suspensions can be a promising formulation for tilmicosin, and that nanoparticle size can be an important consideration for formulation development.

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Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system☆

Cited by 196 publications

References 19 publications

Nanomedicine in pulmonary delivery

Nanomedicine in pulmonary delivery

Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes

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