Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Gomes, M. Thereza M. S.; Santos, Diego T.; Meireles, M. Angela A.

doi:10.5923/j.fph.20120205.05

Cited by 25 publications

(8 citation statements)

References 62 publications

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“…In RESS, the rapid de-pressurization of the supercritical solution causes a substantial lowering of the solvent power of CO 2 leading to very high super-saturation of solute, precipitation, nucleation and particle growth. However, there are some limitations of the method related to the solubility of the polymers in sc CO 2 at the processing temperature [25]. Tsutsumi et al [8] used a combination of the RESS process and a fluidized bed for coating particles.…”

Section: Recent Applications Of Supercritical Fluidmentioning

confidence: 99%

“…Many researchers have studied particle formation and micronization using non-conventional techniques [4][5][6][7][8]10,11,13,[23][24][25][26][28][29][30][31][32][33][34][35]. In this section, some key research reports are highlighted.…”

Section: Recent Applications Of Supercritical Fluidmentioning

confidence: 99%

“…Various techniques can be used to produce micro and nanoparticles. Conventional techniques use freeze drying, spray-cooling, spraydrying, fluidized bed coating, air micronization, coacervation, recrystallization from the liquid solution and sublimation [3]. Nonconventional techniques use supercritical fluid technique that can be divided into three groups according to their role in the processing; (a) Supercritical fluid (SCF) as a solvent which include rapid expansion of supercritical solution (RESS), (b) SCF as a solute which include particles form gas-saturated solutions (PGSS) and (c) SCF as a antisolvent which include supercritical anti-solvent (SAS), gas anti-solvent (GAS), aerosol solvent extraction system (ASES), solution enhanced dispersion by supercritical fluid (SEDS) [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Particle formation and micronization using non-conventional techniques- review

Fahim

Zaidul

Bakar

et al. 2014

Chemical Engineering and Processing: Process Intensification

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Due to growing concerns regarding health, safety and the environment, non-conventional methods for particle formation and micronization that are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO (sc CO ) (T>31.1°C, P>7.3MPa) has been used in food and pharmaceutical industries to minimize the use of organic solvents, produce new food products, produce environmentally superior food products and to process and micronize (0.1-5μm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body. Techniques that use sc CO eliminate inherent drawbacks of conventional methods such as thermal or mechanical degradation of the product, poor control of the particle size and morphology, lack of brittleness of some polymers and low encapsulation efficiency. Several techniques have been reported for the particle formation and micronization using supercritical fluids that have been successfully scaled up for commercial use. Supercritical CO has also been used to develop applications for medicines, essential oils, vitamins, food grade polymers, catalysts and pigments. This review highlights the process mechanism of supercritical fluid based techniques as well as some applications on particle formation and micronization.

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Section: Recent Applications Of Supercritical Fluidmentioning

confidence: 99%

Section: Recent Applications Of Supercritical Fluidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Particle formation and micronization using non-conventional techniques- review

Fahim

Zaidul

Bakar

et al. 2014

Chemical Engineering and Processing: Process Intensification

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“…Oil-in-water nanoemulsions and microemulsions are two basic colloidal dispersion systems suitable for the delivery of lipophilic β-carotene for food applications. The literature also reports several techniques for the preparation of micro/nanoemulsions, such as emulsion phase inversion [292], high-pressure homogenization [293], microfluidization [144,294], supercritical fluid methods [145,295], spontaneous emulsification [296] and phase-inversion temperature [297].…”

Section: Micro/nanoemulsionsmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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“…Oil-in-water nanoemulsions and microemulsions are two basic colloidal dispersion systems suitable for the delivery of lipophilic β-carotene for food applications. Literature also reports several techniques for the preparation of micro/nano emulsions, such as emulsion phase inversion [195], high pressure homogenization [196], microfluidization [197,198], supercritical fluid methods [199,200], spontaneous emulsification [201] and phase-inversion temperature [202].…”

Section: Micro/nano Emulsionsmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya¹,

Shakya²,

Aggarwal³

et al. 2021

Preprint

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Accruing evidence on the influence of β-carotene regarding the prevention of several chronic diseases - in addition to its well-acknowledged role in vision has been a strong driver for developing alternative delivery systems. Though oral delivery is accepted as the most fitting, mild and safe path for delivering bioactive agents, β-carotene delivery via food items poses challenges due to its lipophilic nature, poor water-solubility, high chemical/photochemical instability and poor oral bioavailability. Nanotechnology has opened new windows for delivering bioactive agents. Their physiochemical characteristics, i.e. small size, high surface area, unique composition, biocompatibility and biodegradability make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers inherit some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has been rapidly evolved, with a plethora of innovative nano-engineered materials, including micelles, nano/microemulsion, liposomes, niosomes, solid-lipid nanoparticles and nanostructured lipid carriers. These nano-delivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nano-delivery systems adopted for developing functional foods: depicting their classification, composition, preparation methods, challenges, release-and absorption of β-carotene in the GIT and possible risks and future prospects.

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Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Cited by 25 publications

References 62 publications

Particle formation and micronization using non-conventional techniques- review

Particle formation and micronization using non-conventional techniques- review

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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