Production of optically pure lactic acid by microbial fermentation: a review

Rawoof, Salma Aathika Abdur; Kumar, P. Senthil; Vo, Dai‐Viet N.; Devaraj, Kubendran; Mani, Yuvarani; Devaraj, Thiruselvi; Sivanesan, S.

doi:10.1007/s10311-020-01083-w

Cited by 79 publications

(31 citation statements)

References 119 publications

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“…The accumulation of acid anion inside the cell was reported to inhibit cellular function via several mechanisms. For instance, it has been reported that the accumulation of dissociated acid in the cell can cause growth slowdown and death due to the increase in the cell energy consumption in an attempt to pump out the protons outside the cell [ 17 , 26 ]. Although fermentation ceased at 48 h due to the low levels of substrate concentration used, the results demonstrated that pH control may be necessary when increasing the substrate concentration.…”

Section: Resultsmentioning

confidence: 99%

“…pH control of the fermentation broth during the fermentation process through base titration or lactic acid removal (e.g., extraction, adsorption or electrodialysis) results in higher lactic acid production, yield and productivity [ 11 , 25 ]. Regarding the fermentation operational mode, although batch fermentations have been widely used due to higher production of lactic acid, it has been reported that continuous and fed-batch mode could achieve better production yields compared to batch mode [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Lactic acid production by Carnobacterium sp. isolated from a maritime Antarctic lake using eucalyptus enzymatic hydrolysate

Camesasca

Mattos

Vila

et al. 2021

Biotechnology Reports

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Highlights Eucalyptus enzymatic hydrolysate contained mixture of glucose and xylose sugars. Carnobacterium sp. produced lactic acid from eucalyptus enzymatic hydrolysate. Glucose was consumed faster and completely rather than xylose during fermentation. Fed-batch fermentation improved lactic acid production and reached 30 g/L.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lactic acid production by Carnobacterium sp. isolated from a maritime Antarctic lake using eucalyptus enzymatic hydrolysate

Camesasca

Mattos

Vila

et al. 2021

Biotechnology Reports

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“…LA can be generated either by chemical synthesis from hydrocarbon-based sources or by microbial fermentation routes. A racemic form of D-/L-lactic acid is obtained through chemical routes, which have limited applications, whereas optical pure D-or L-lactic acid can be obtained by microbial fermentation [6]. Microbial production of LA has more benefits, including cheap raw materials and mild production conditions.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Huang

Xue

et al. 2021

Molecules

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Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure l- or d-lactic acid has increased accordingly. Microbial fermentation is the industrial route for LA production. LA bacteria and certain genetic engineering bacteria are widely used for LA production. Although some fungi, such as Saccharomyces cerevisiae, are not natural LA producers, they have recently received increased attention for LA production because of their acid tolerance. The main challenge for LA bioproduction is the high cost of substrates. The development of LA production from cost-effective biomasses is a potential solution to reduce the cost of LA production. This review examined and discussed recent progress in optically pure l-lactic acid and optically pure d-lactic acid fermentation. The utilization of inexpensive substrates is also focused on. Additionally, for PLA production, a complete biological process by one-step fermentation from renewable resources is also currently being developed by metabolically engineered bacteria. We also summarize the strategies and procedures for metabolically engineering microorganisms producing PLA. In addition, there exists some challenges to efficiently produce PLA, therefore strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are also discussed.

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“…The way fermentation is conducted also exerts an influence on the productivity and yield of the production of this organic acid. Batch fermentation is easier to operate, results in a high titer and has a lower risk of contamination, but productivity is low and inhibition occurs due to the substrate and final product [36]. Fedbatch fermentation involves the continual addition of substrate to the fermentation medium throughout the cultivation process.…”

Section: Introductionmentioning

confidence: 99%

Production of L (+) Lactic Acid by Lactobacillus casei Ke11: Fed Batch Fermentation Strategies

et al. 2021

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Lactic acid and its derivatives are widely used in pharmaceutical, leather, textile and food industries. However, until now there have been few systematic reports on fed-batch fermentation for efficient production and high concentration of l-lactic acid by lactic acid bacteria. This study describes the obtainment of L (+) lactic acid from sucrose using the Lactobacillus casei Ke11 strain through different feeding strategies using an accessible pH neutralizer such as CaCO3. The exponential feeding strategy can increase lactic acid production and productivity (175.84 g/L and 3.74 g/L/h, respectively) with a 95% yield, avoiding inhibition by high initial substrate concentration and, combined with the selected agent controller, avoids the cellular stress that could be caused by the high osmotic pressure of the culture media. The purification of the acid using charcoal and celite, followed by the use of a cation exchange column proved to be highly efficient, allowing a high yield of lactic acid, high removal of sugars and proteins. The described process shows great potential for the production of lactic acid, as well as the simple, efficient and low-cost purification method. This way, this work is useful to the large-scale fermentation of L. casei Ke11 for production of l-lactic acid.

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Production of optically pure lactic acid by microbial fermentation: a review

Cited by 79 publications

References 119 publications

Lactic acid production by Carnobacterium sp. isolated from a maritime Antarctic lake using eucalyptus enzymatic hydrolysate

Lactic acid production by Carnobacterium sp. isolated from a maritime Antarctic lake using eucalyptus enzymatic hydrolysate

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Production of L (+) Lactic Acid by Lactobacillus casei Ke11: Fed Batch Fermentation Strategies

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