Production of insulin-like growth factor binding proteins (IGFBPS) by human endometrial stromal cells is stimulated by the presence of embryos

Liu, Hung Ching; Mele, Carol Ann; Catz, Diana; Noyes, N.; Rosenwaks, Zev

doi:10.1007/bf02211374

Cited by 35 publications

(16 citation statements)

References 23 publications

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“…64 Interestingly, the presence of embryo also upregulates the production of insulin-like growth factor binding proteins (IGFBPs) by human endometrial stromal cells. 65 Thus, it appears that endometrial receptivity during the mid-luteal phase of cycle is likely to be associated with differential activation and repression of various cohorts of genes in endometrium under progesterone action following signal inputs from viable, synchronously developing embryo.…”

Section: Embryo Endometrial Dialoguementioning

confidence: 99%

Endometrial Receptivity and Human Embryo Implantation

Rashid

Lalitkumar

et al. 2011

American J Rep Immunol

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Citation Rashid NA, Lalitkumar S, Lalitkumar PG, Gemzell‐Danielsson K. Endometrial Receptivity and Human Embryo Implantation. Am J Reprod Immunol 2011; 66 (Suppl. 1): 23–30Problem The pre‐requisite of successful implantation involves an intricate cascade of molecular interactions which plays a crucial role in preparing receptive endometrium and implanting blastocyst.Method of study Data are hereby presented for a better understanding of endometrial receptivity in women, hoping to provide a comprehensive picture of the process and identify new areas of basic and translational research in the biology of blastocyst implantation.Results Timely regulation of the expression of a number of complex molecules like hormones, cytokines and growth factors, and their crosstalk from embryonic and maternal endometrial side play a major role in determining the fate of the embryo. The molecular basis of endometrial receptivity and the mechanisms by which the blastocyst first adheres to the luminal epithelium and then penetrates into the stroma are only just beginning to be resolved.Conclusion Advances in the development of implantation models and ‘omics’ technologies, particularly proteomics and metabolomics, are set to have a major impact on the development of this field.

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Section: Embryo Endometrial Dialoguementioning

confidence: 99%

Endometrial Receptivity and Human Embryo Implantation

Rashid

Lalitkumar

et al. 2011

American J Rep Immunol

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“…In this study, endometrial expression of IGFBP3, IGFBP4 and IGFBP5 mRNA at day 7 of oestrous cycle was affected by nutritional treatments, being greater in TMR and HA than MA cows. The increased in IGFBP3 mRNA supports a stimulatory role of this protein during early pregnancy as it has been reported that its expression responds to embryonic signals (Liu, Mele, Catz, Noyes, & Rosenwaks, ) and theorized that it may aid in the transportation of systemic IGF to its target site (Robinson et al., ). Several studies demonstrated that during development IGF2 and IGFBP4 mRNA are co‐expressed with IGF2 in many tissues indicating a potential interaction between IGF2 and IGFBP4 in growth and a possibly reservoir of IGF within tissues (Ning, Schuller, Conover, & Pintar, ).…”

Section: Discussionmentioning

confidence: 69%

Endometrial gene expression in primiparous dairy cows at the end of the voluntary waiting period is affected by nutrition: Total mixed ration vs increasing levels of herbage allowance

Astessiano

Carriquiry

Mattiauda

et al. 2017

Reprod Domestic Animals

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The study postulated that differential nutritional management during the early lactation period would be reflected in endometrial expression of genes related to embryo growth at the end of the voluntary waiting period. Thus, the effect of the combined use of total mixed ration (TMR) and grazing under different herbage allowances during the first 75 days post-partum (DPP) on endometrial gene expression was evaluated in primiparous dairy cows. Cows were blocked by body weight, age and body condition score and randomly assigned to three grazing treatments: high (HA, 30 kg DM per cow per day), medium (MA, 15 kg DM per cow per day) and low (LA, 7.5 kg DM per cow per day) herbage allowance (mixed pasture, 2,600 kg DM per ha) plus 8 kg DM of supplement or TMR (55% forage, 45% concentrate) fed ad libitum (TMR) from calving to 75 DPP. At 57 DPP, cows were synchronized for oestrus (day 0, 68 DPP) and at day 7, endometrial biopsies were obtained. The nutritional treatment did not affect insulin, IGF-1 and leptin concentrations on days 0, 4 or 7. Expression of IGF1, IGFBP3, IGFBP4, ADIPOR1 and ADIPOR2 mRNA was significantly affected by the nutritional treatment. Endometrial IGF1 and IGFBP4 mRNA were twofold greater in TMR and HA than MA and LA cows. Expression of IGFBP3 and ADIPOR1 mRNAs was greater in TMR and HA than MA cows, but did not differ from LA cows. All groups had greater expression of ADIPOR2 mRNA than MA cows. This study provided solid evidence of the importance of nutritional management during early lactation on uterine environment at the end of the voluntary waiting period. The greater expression of genes related to embryo growth and uterine function (IGF system, progesterone and adiponectin receptors) in cows fed diets maximizing energy intake suggests a favourable environment for embryonic growth, which may explain the improved reproductive performance of cows in good energy balance.

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“…Vero cells, which promote early embryonic development in coculture [19], release IGFBP3 into the culture medium [20], and the culture medium containing the most IGFBP3 was the most effective at promoting development. In addition, granulosa cells [48,49], oviductal and endometrial cells [20,50], and liver cells [51,52] promote development of conceptuses in vitro, and these cells all secrete IGFBP3 [15,20,[53][54][55][56]. In all these coculture systems, IGFBP3 may be one of the factors that supports development.…”

Section: Discussionmentioning

confidence: 99%

Horse Conceptuses Secrete Insulin-Like Growth Factor-Binding Protein 31

Herrler

Pell

Allen

et al. 2000

Biology of Reproduction

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Insulin-like growth factor-I (IGF-I) promotes early embryonic development in several species. In the rabbit, IGF-I binds to the embryonic coats from Day 3 of development onward by a 38-kDa protein that is probably insulin-like growth factor-binding protein 3 (IGFBP3). In the present study, ligand, Western, and Northern blot analyses were used to demonstrate the presence of IGF-I-binding activity, several immunoreactive IGFBP3 proteins, and IGFBP3 mRNA in horse conceptuses with particularly large amounts of immunoreactive IGFBP3 in the conceptus capsule. In addition, immunoprecipitation of radiolabeled proteins showed that cultured horse conceptuses secreted IGFBP3 into the culture medium. Endometrial samples from mares also contained IGFBP3 mRNA and protein; but there was no evidence of secretion of IGFBP3 into the uterine lumen by ligand blot analysis, and there was evidence of only very small amounts by Western blot analysis. These results indicate that the horse conceptus secretes significant quantities of IGFBP3 toward the conceptus capsule from as early as Day 10 after ovulation. Thus, most of the IGFBP3 contained within the capsule, which binds IGF-I to this special extracellular matrix of the preimplantation horse conceptus, is likely to be embryonic in origin. IGFBP3 in the horse conceptus capsule may enhance or modulate the action of IGFs on the developing conceptus.

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Production of insulin-like growth factor binding proteins (IGFBPS) by human endometrial stromal cells is stimulated by the presence of embryos

Cited by 35 publications

References 23 publications

Endometrial Receptivity and Human Embryo Implantation

Endometrial Receptivity and Human Embryo Implantation

Endometrial gene expression in primiparous dairy cows at the end of the voluntary waiting period is affected by nutrition: Total mixed ration vs increasing levels of herbage allowance

Horse Conceptuses Secrete Insulin-Like Growth Factor-Binding Protein 31

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