Production of carrier/antioxidant particles by Supercritical Assisted Atomization as an adjuvant treatment of the CoVID-19 pathology

Salicylic Acid Co-Precipitation with Alginate via Supercritical Atomization for Cosmetic Applications

“…The loaded microparticles showed a thermogram similar to that of sodium alginate alone, suggesting that the drug became amorphous after supercritical processing. This behavior was already observed in other crystalline drugs [ 18 , 25 ], and it was due to the fast SC-CO 2 -assisted atomization that avoided the re-organization of the dissolved molecules in an ordinate form, together with the blockage of the dispersed particles of the drug in the polymeric matrix after solvent removal; both these contributions favored the amorphous state of the drug [ 22 ].…”

“…More specifically, solution jet break-up is influenced by the competition between inertial forces (such as velocity at the injector nozzle) and cohesive forces (mainly viscosity and surface tension) that are computed in dimensionless numbers (e.g., Reynolds, Weber, and Ohnesorge numbers) generally used for the description of atomization processes. Therefore, even if a gas-expanded liquid characterized by reduced cohesive forces with respect to the corresponding liquid [ 20 , 21 ] was formed in the saturator before the injection step, the biopolymer concentration had a non-negligible effect on the final microparticle mean size; indeed, it influenced the obtainment of larger solution droplets that produced larger alginate microparticles after solvent evaporation [ 18 , 22 ].…”

“…The apparatus was completed by a separator for the recovery of the liquid solvent. SAA apparatus layout and further details about the experimental procedure are described in [ 18 , 22 ].…”

“…Operating in this way, the intrinsic cohesive forces, such as surface tension and viscosity, of the polymeric liquid solution are reduced because of the interposition of supercritical CO 2 (SC-CO 2 ) molecules among liquid molecules [ 21 ]. Therefore, the main advantages of this technique over the traditional ones are related to the possibility of obtaining smaller droplets exiting the injector that, after solvent evaporation induced by hot nitrogen, can be collected on a stainless-steel filter at the bottom of the precipitation chamber, in the form of microparticles [ 17 , 18 , 19 , 22 ]. Moreover, a good reproducibility in terms of particle size and size distribution can be assured, avoiding aggregation phenomena among particles [ 23 ].…”

Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery

“…[ 7 , 8 , 9 ]. Recently NSAIDs, in particular ibuprofen, have been widely used in the home management of non-serious cases of COVID-19 [ 10 , 11 ], in therapies involving the use of NSAIDs and antioxidant compounds or vitamin complexes [ 12 , 13 , 14 ]. One of the main limitations of the use of NSAIDs is linked to their poor water solubility.…”