Production of inclusion complexes containing corticosteroids by SAA process

Mottola, Stefania; De Marco, Iolanda

doi:10.1016/j.supflu.2023.106115

Cited by 1 publication

(1 citation statement)

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“…Among the innovative techniques used in the pharmaceutical field to obtain carrier/active principle composites, the ones based on supercritical carbon dioxide (scCO 2 ) are particularly attractive [ 20 , 21 , 22 ]. Indeed, fluids at supercritical conditions have peculiar characteristics, intermediate between the ones of a gas (like diffusivity) and a liquid (e.g., density) [ 23 , 24 , 25 ]. Among the supercritical fluids-based processes used to micronize and/or coprecipitate APIs, the supercritical antisolvent (SAS) precipitation is particularly used as it exploits the solubility of many APIs in organic solvents and the miscibility of these solvents in scCO 2 under process conditions.…”

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confidence: 99%

Curcumin/Carrier Coprecipitation by Supercritical Antisolvent Route

Mottola,

De Marco

2024

Pharmaceutics

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In this work, polyvinylpyrrolidone (PVP)- and β-cyclodextrin (β-CD)-based composite powders containing curcumin (CURC) were obtained through the supercritical antisolvent (SAS) technique. Pressure, total concentration of CURC/carrier in dimethylsulfoxide, and CURC/carrier ratio effects on the morphology and size of the precipitated powders were investigated. Using PVP as the carrier, spherical particles with a mean diameter of 1.72 μm were obtained at 12.0 MPa, 20 mg/mL, and a CURC/PVP molar ratio equal to 1/2 mol/mol; using β-CD as the carrier, the optimal operating conditions were 9.0 MPa and 200 mg/mL; well-defined micrometric particles with mean diameters equal to 2.98 and 3.69 μm were obtained at molar ratios of 1/2 and 1/1 mol/mol, respectively. FT-IR spectra of CURC/ β-CD inclusion complexes and coprecipitated CURC/PVP powders revealed the presence of some peaks of the active compounds. The stoichiometry of the complexes evaluated through the Job method revealed that β-CD formed inclusion complexes with CURC at a molar ratio equal to 1/1. Dissolution profiles revealed that in comparison with the curve of the pure ingredient, the SAS-processed powders obtained using both PVP and β-CD have an improved release rate.

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