Production of Asymmetrical Particles in a Crystallization Process Using Liquid-Liquid Interfaces

Kadota, Kazunori; Tanida, Satoshi; Shirakawa, Yoshiyuki; Shimosaka, Atsuko; Hidaka, Jusuke

doi:10.1252/jcej.40.217

Cited by 21 publications

(7 citation statements)

References 13 publications

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“…This suggests that maintaining the interface and forming a supersaturation gradient is more advantageous for crystallization than mixing the solution well in the channel due to slow flow. The solvent and anti-solvent with low supersaturation become high supersaturation at their interface [35], and the concentration gradient covers the nucleation conditions by varying degree of supersaturation. This may be related to the phenomenon whereby a surface always tries to minimize its energy.…”

Section: Discussionmentioning

confidence: 99%

Microflow system promotes acetaminophen crystal nucleation

Nishigaki

Maruyama

Numata

et al. 2020

Engineering in Life Sciences

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It is known that interfaces have various impacts on crystallization from a solution. Here, we describe crystallization of acetaminophen using a microflow channel, in which two liquids meet and form a liquid–liquid interface due to laminar flow, resulting in uniform mixing of solvents on the molecular scale. In the anti‐solvent method, the microflow mixing promoted the crystallization more than bulk mixing. Furthermore, increased flow rate encouraged crystal formation, and a metastable form appeared under a certain flow condition. This means that interface management by the microchannel could be a beneficial tool for crystallization and polymorph control.

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Section: Discussionmentioning

confidence: 99%

Microflow system promotes acetaminophen crystal nucleation

Nishigaki

Maruyama

Numata

et al. 2020

Engineering in Life Sciences

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“…The numbers in both cases slightly increase with increasing the simulation time. 8 It seems to come from the speed of the dehydration in the mutual diffusion near the interface attributed to weakness of the interaction between K + and water molecule as mentioned above. Moreover, the cumulated value is also larger than that in the case of NaCl solution.…”

Section: Dehydration and Clustering Processesmentioning

confidence: 96%

“…However, the former two methods have some problems concerning thermal energy in the process of the crystallization. 8 Figure 1 shows a phase diagram of water/1-butanol as a typical example. The temperature distribution in the system results in a broad size distribution of precipitated particles.…”

Section: Diffusion Behavior In a Liquid-liquid Interfacial Crystallizmentioning

confidence: 99%

Diffusion behavior in a liquid-liquid interfacial crystallization by molecular dynamics simulations

Kitayama

Yamanaka

Kadota

et al. 2009

The Journal of Chemical Physics

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Interfacial crystallization, such as surface crystallization in solution (solid-liquid) and liquid-liquid crystallization, gives us an asymmetric reaction field and is a technique for morphology control of crystals. In the liquid-liquid crystallization, the concentration distribution of solute ions and solvent molecules at the liquid-liquid interface directly relates to nucleation, crystal growth, and crystal morphology. Nonequilibrium molecular dynamics (MD) simulations have been performed at interfaces in NaCl solution/1-butanol and KCl solution/1-butanol system in order to clarify diffusion behavior of solute ions and solvent molecules. As simulation results, the hydrated solute ions were dehydrated with the diffusion of water from solution phase into 1-butanol phase. The different dehydration behaviors between NaCl and KCl solution can be also obtained from MD simulation results. Aggregated ions or clusters were formed by the dehydration near the solution/1-butanol interface. By comparison on the normalized number of total solute ions, the size and number of generated cluster in KCl solution/1-butanol interface are larger than those in the NaCl system. This originates in the difference hydration structures in the each solute ion.

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“…We produced asymmetrical crystals that had a stepwise structure on the organic solvent side by liquid-liquid interfacial crystallization [16]. The asymmetry arises from the movement of precipitation crystals by self-weight and the concentration difference of NaCl between two solvents at the interface [16,17].…”

Section: Calculation Of the Supersaturation Ratio Distribution Near Tmentioning

confidence: 99%

“…Liquid-liquid interfacial crystallization has been developed as a specific interfacial reaction field [16,17]. In interfacial synthesis, crystals precipitate and grow on the liquid-liquid interface through mutual diffusion between the liquids.…”

Section: Introductionmentioning

confidence: 99%