Production of antimicrobial metabolites against pathogenic bacteria and yeasts by Fusarium oxysporum in submerged culture processes

Poleto, Liliane; Rosa, Letícia Osório da; Fontana, Roselei Claudete; Rodrigues, Eliseu; Poletto, Édina; Baldo, Guilherme; Paesi, Suelen; Sales-Campos, Ceci; Camassola, Marli

doi:10.1007/s00449-021-02538-2

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…In addition, F. graminearum Ec220 produces a xylanase with low cellulase content when grown on wheat bran [ 191 ], which has good commercial prospects. FOV PR-33 produces fusarinolic acid and its isomers, dehydrofusaric acid and fusaric acid, which are resistant to pathogenic bacteria and yeasts; these metabolites are potential antibacterial drugs [ 192 ]. Bananas are highly susceptible to Fusarium infection [ 193 ]; therefore, they could be considered for Fusarium cultivation for the production of compounds with industrial applications.…”

Section: Discussionmentioning

confidence: 99%

Defense Mechanisms of Cotton Fusarium and Verticillium Wilt and Comparison of Pathogenic Response in Cotton and Humans

Man

Zhu

Liu

et al. 2022

IJMS

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Cotton is an important economic crop. Fusarium and Verticillium are the primary pathogenic fungi that threaten both the quality and sustainable production of cotton. As an opportunistic pathogen, Fusarium causes various human diseases, including fungal keratitis, which is the most common. Therefore, there is an urgent need to study and clarify the resistance mechanisms of cotton and humans toward Fusarium in order to mitigate, or eliminate, its harm. Herein, we first discuss the resistance and susceptibility mechanisms of cotton to Fusarium and Verticillium wilt and classify associated genes based on their functions. We then outline the characteristics and pathogenicity of Fusarium and describe the multiple roles of human neutrophils in limiting hyphal growth. Finally, we comprehensively compare the similarities and differences between animal and plant resistance to Fusarium and put forward new insights into novel strategies for cotton disease resistance breeding and treatment of Fusarium infection in humans.

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Section: Discussionmentioning

confidence: 99%

Defense Mechanisms of Cotton Fusarium and Verticillium Wilt and Comparison of Pathogenic Response in Cotton and Humans

Man

Zhu

Liu

et al. 2022

IJMS

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“…Fusaric acid (129), one of the most significant mycotoxins from Fusarium strains, displayed a broad spectrum of moderate antimicrobial activity against Bacillus species, Acinetobacter baumannii, Phytophthora infestans, etc. [75][76][77]. Equisetin (130) was shown to be active against several strains of Gram-positive bacteria (B. subtilis, Mycobacterium phlei, S. aureus, methicillin-resistant S. aureus, and S. erythraea) and the Gram-negative bacteria Neisseria perflava at concentrations of 0.5-4.0 µg/mL, as well as antifungal activity toward P. syringae and R. cerealis [78,79].…”

Section: Antiviral Secondary Metabolitesmentioning

confidence: 99%

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Huang

Zhu

et al. 2023

Molecules

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Fungal microbes are important in the creation of new drugs, given their unique genetic and metabolic diversity. As one of the most commonly found fungi in nature, Fusarium spp. has been well regarded as a prolific source of secondary metabolites (SMs) with diverse chemical structures and a broad spectrum of biological properties. However, little information is available concerning their derived SMs with antimicrobial effects. By extensive literature search and data analysis, as many as 185 antimicrobial natural products as SMs had been discovered from Fusarium strains by the end of 2022. This review first provides a comprehensive analysis of these substances in terms of various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic. Future prospects for the efficient discovery of new bioactive SMs from Fusarium strains are also proposed.

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Genetic, Epigenetic, and Physicochemical Strategies to Improve the Pharmacological Potential of Fungal Endophytes

Naitam,

Upadhyay,

Lavanya

et al. 2024

Fungal Biology

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Production of antimicrobial metabolites against pathogenic bacteria and yeasts by Fusarium oxysporum in submerged culture processes

Cited by 5 publications

References 35 publications

Defense Mechanisms of Cotton Fusarium and Verticillium Wilt and Comparison of Pathogenic Response in Cotton and Humans

Defense Mechanisms of Cotton Fusarium and Verticillium Wilt and Comparison of Pathogenic Response in Cotton and Humans

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Genetic, Epigenetic, and Physicochemical Strategies to Improve the Pharmacological Potential of Fungal Endophytes

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