Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Abstract

Fungal microbes are important in the creation of new drugs, given their unique genetic and metabolic diversity. As one of the most commonly found fungi in nature, Fusarium spp. has been well regarded as a prolific source of secondary metabolites (SMs) with diverse chemical structures and a broad spectrum of biological properties. However, little information is available concerning their derived SMs with antimicrobial effects. By extensive literature search and data analysis, as many as 185 antimicrobial natural products as SMs had been discovered from Fusarium strains by the end of 2022. This review first provides a comprehensive analysis of these substances in terms of various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic. Future prospects for the efficient discovery of new bioactive SMs from Fusarium strains are also proposed.

Longitudinal Distribution Map of the Active Components and Endophytic Fungi in Angelica sinensis (Oliv.) Diels Root and Their Potential Correlations

“…One of the main functions of Ang is to regulate female menstruation. Intervention with hormones, especially oestrogen, may play an important role in this process [ 39 ]. In the negative ion mode, 61 active metabolic compounds were dominant in the ART; more than 20% of them may have the potential to improve the haemodynamics, such as homocitrate, L-anserine, zingerone, cis-9-palmitoleic acid, deoxysappanone B 7,3’-dimethyl ether, myo-inositol, 5-methyltetrahydrofolate, raffinose, salidroside, naringin, neg_5372 (potential structural analogue of bosentan) and neg_5789 (potential structural analogue of lisinopril).…”

“…Among these fungi, species belonging to Calophoma , Paecilomyces , Alternaria , Cladosporium , Plectosphaerella , Fusarium , and Aspergillus have been identified as the dominant endophytes in some medicinal plants [ 21 , 40 ]. Many strains contained in Paecilomyces , Alternaria , Cladosporium , Plectosphaerella , Fusarium, and Aspergillus also reportedly produce important bioactive metabolites [ 39 , 41 ]. Paecilomyces , Cladosporium, and Plectosphaerella have significant plant growth-promoting effects [ 42 , 43 ] and are typical biocontrol microbes [ 42 ].…”

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

“…Four substances, namely rosmarinic acid, myricitrin, quercitrin, and ofloxacin, have exhibited a substantial affinity for monkeypox DNA topoisomerase I, indicating potential antiviral properties. The stability of this system has been confirmed through simulations of molecular dynamics [ 151 , 152 ]. Research conducted by another group has underscored the potential use of these chemicals as inhibitors of poxviruses, emphasizing the necessity for additional investigations to evaluate their therapeutic effectiveness [ 153 ].…”

Looking for Fusarium Resistance in Oats: An Update

“…To optimize the use of microbial agents to control FHB, it is essential to understand how Fusarium employs effector proteins to modulate the microbiome composition and promote disease development in the host [116]. Specialized metabolites produced by the Fusarium spp., acting as effectors, can have antimicrobial effects [117,118] in order to compete with other microbes colonizing the host [119]. DON is phytotoxic and considered a virulence factor of fungal pathogens, and DON resistance is a component of FHB resistance [120].…”