Production and Characterization of Biodegradable Povidone-iodine Microsphere as a Intramammary Disinfectant.

Abstract

ABSTRACT. Microspheres composed of biocompatible, biodegradable poly dl-lactide-co-glycolide (DL-PLGA) and Povidone-iodine were evaluated as an intramammary disinfectant delivery system in vitro prior to infusion into mammary glands. Microsphere was prepared by solvent evaporation method and particle size, morphology and in vitro release kinetics were examined. The microspheres were ranged in size from 25 µm to 155 µm (mean diameter = 65.7 µm). Povidone-iodine was dispersed on the surface of microsphere and microsphere was spherical in shape with a smooth surface. The yield of microsphere was 57.3% and the encapsulation efficiency was 69 .6%. In in vitro release study, a burst effect (50.9%) was observed during the first two days and a sustained release then continued for the next 28 days. Results of the present study demonstrated that microsphere have the potential for new intramammary disinfectant formulations that can provide increased efficacy of therapy against mastitis pathogens. KEY WORDS: DL-PLGA, intramammary disinfectant, mastitis, Povidone-iodine.

Aspects in controlled drug delivery for topical applications in veterinary medicine

“…Most of the products are provided either as solutions or as lipid-based liquid formulations, although the possibility for exploiting microparticulate systems is acknowledged. Inspired by this, perhaps, a study was performed with povidone-iodine microencapsulated into polyglycolides ( Park & Han, 2002 ). Microspheres measuring between 25 and 155 µm yielded a burst effect in vitro , releasing over 50% of the iodine immediately, and the remainder over 28 days, indicating its possible utility in the treatment of mastitis in the dry period.…”

Health care-associated infections: Controlled delivery of cationic antiseptics from polymeric excipients

“…Specifically, in order to efficiently encapsulate antiseptics in MPs, the polymer-drug interaction has to be enhanced. In fact, PLGA MPs providing a sustained release of the antiseptic were investigated in a formulation of povidone-iodine, as an intramammary disinfectant delivery system 142 . Despite the sustained diffusion of the antiseptic compound over 28 days, the moderate drug encapsulation and the significant initial burst lowered the formulation efficacy.…”