Drug Delivery Systems in Domestic Animal Species

Brayden, David J.; Oudot, Emilie J. M.; Baird, Alan W.

doi:10.1007/978-3-642-10324-7_4

Cited by 19 publications

(17 citation statements)

References 158 publications

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“…The use of pMDI and DPI devices require the cooperation of the subject and are inappropriate in animals due to the inability to control their inhalation. Therefore, nebulization is the most common technique for delivery of aerosols in animals (2) In veterinary medicine, aerosol delivery has been optimized for several laboratory animal models (9) and has also been described for various species of companion animals (7,12,13). For years, nebulization techniques for aqueous solutions and suspensions have been used in companion avian clinical practice to deliver prophylactic therapeutics and/or medications such as antibiotics (17) and antifungals.…”

Section: Introductionsupporting

confidence: 40%

Study of Nebulization Delivery of Aerosolized Fluorescent Microspheres to the Avian Respiratory Tract

Tell¹,

Stephens²,

Teague³

et al. 2012

Avian Diseases Digest

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SUMMARYThis study investigated the delivery of an aerosol of monodisperse microspheres to the respiratory tract of birds following aerosol exposure. Adult domestic pigeons (Columbia livia domestica; n=5 birds per timed treatment) were exposed to an aerosol of fluorescent 1.0 μm diameter carboxylate microspheres for 0.5, 1, 2 or 4 hr. During the aerosolization period, the birds were free standing in a plexiglass treatment chamber, and the aerosol was delivered using a commercial nebulizer. Immediately following aerosol exposure the birds were euthanized and the carcasses were intravenously infused with a modified paraformaldehyde/gluteraldehyde fixative. Evaluation of microsphere distribution was performed using a stereoscopic microscope with an epifluorescent module. The results from this study revealed that the amount of aerosolized particles delivered using a commercial nebulizer was proportional to exposure periods. Aerosol exposure periods of 0.5 h or 1 h did not result in a readily observable distribution of 1.0 μm fluorescent microspheres to the cranial thoracic, caudal thoracic, or abdominal air sac membranes. This was partly attributed to the relatively low concentration of the individual monodisperse microspheres in the aerosolized suspension. The 2 and 4 hr exposure periods resulted in readily observable deposition of the 1.0 μm fluorescent microspheres in the cranial thoracic, caudal thoracic, or abdominal air sac membranes with the 4 hr exposure period resulting in the greatest number of particles on the membrane surfaces. For each of the exposure periods there was individual animal variation regarding the distribution and relative number of spheres deposited. This study demonstrates the widespread deposition of particles that had an aerodynamic equivalent diameter of approximately 1 μm and provides a better understanding of particle deposition efficiency within the respiratory system following aerosol exposure in birds.

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Section: Introductionsupporting

confidence: 40%

Study of Nebulization Delivery of Aerosolized Fluorescent Microspheres to the Avian Respiratory Tract

Tell¹,

Stephens²,

Teague³

et al. 2012

Avian Diseases Digest

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“…They couple ATP hydrolysis to active transport of a wide variety of substrates such as sugars, peptides, proteins, lipids, sterols, ions, and drugs. Prokaryotic antibiotic resistance and eukaryotic multi-drug resistance is associated with ABC transporters, which acts as a modulator of drug absorption and distribution [45, 46]. …”

Section: Resultsmentioning

confidence: 99%

Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds

et al. 2017

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Whole-genome re-sequencing, alignment and annotation analyses were undertaken for 12 sires representing four important cattle breeds in Brazil: Guzerat (multi-purpose), Gyr, Girolando and Holstein (dairy production). A total of approximately 4.3 billion reads from an Illumina HiSeq 2000 sequencer generated for each animal 10.7 to 16.4-fold genome coverage. A total of 27,441,279 single nucleotide variations (SNVs) and 3,828,041 insertions/deletions (InDels) were detected in the samples, of which 2,557,670 SNVs and 883,219 InDels were novel. The submission of these genetic variants to the dbSNP database significantly increased the number of known variants, particularly for the indicine genome. The concordance rate between genotypes obtained using the Bovine HD BeadChip array and the same variants identified by sequencing was about 99.05%. The annotation of variants identified numerous non-synonymous SNVs and frameshift InDels which could affect phenotypic variation. Functional enrichment analysis was performed and revealed that variants in the olfactory transduction pathway was over represented in all four cattle breeds, while the ECM-receptor interaction pathway was over represented in Girolando and Guzerat breeds, the ABC transporters pathway was over represented only in Holstein breed, and the metabolic pathways was over represented only in Gyr breed. The genetic variants discovered here provide a rich resource to help identify potential genomic markers and their associated molecular mechanisms that impact economically important traits for Gyr, Girolando, Guzerat and Holstein breeding programs.

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“…The average veterinary expenditure per household in the U.S. was about 366 USD per year in 2006 [1]. Furthermore, it has been predicted that the world animal health market will be valued at 30 billion USD by the year 2020 [50].…”

Section: Discussionmentioning

confidence: 99%

“…Typically the optimal products must be cost-effective, safe, easily administered [1], demonstrate in vivo efficacy, be nontoxic, and display favourable pharmacokinetics [2]. The final factor is the most salient as 90% of potential therapeutic agents have low bioavailability and poor pharmacokinetics [2].…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Liposome-Based Veterinary Therapeutics

Sadozai¹,

Saeidi²

2013

ISRN Veterinary Science

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Recent advances in nanomedicine have been studied in the veterinary field and have found a wide variety of applications. The past decade has witnessed a massive surge of research interest in liposomes for delivery of therapeutic substances in animals. Liposomes are nanosized phospholipid vesicles that can serve as delivery platforms for a wide range of substances. Liposomes are easily formulated, highly modifiable, and easily administered delivery platforms. They are biodegradable and nontoxic and have long in vivo circulation time. This review focuses on recent and ongoing research that may have relevance for veterinary medicine. By examining the recent developments in liposome-based therapeutics in animal cancers, vaccines, and analgesia, this review depicts the current significance and future directions of liposome-based delivery in veterinary medicine.

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Drug Delivery Systems in Domestic Animal Species

Cited by 19 publications

References 158 publications

Study of Nebulization Delivery of Aerosolized Fluorescent Microspheres to the Avian Respiratory Tract

Study of Nebulization Delivery of Aerosolized Fluorescent Microspheres to the Avian Respiratory Tract

Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds

Recent Developments in Liposome-Based Veterinary Therapeutics

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