Health care-associated infections: Controlled delivery of cationic antiseptics from polymeric excipients

Lisi, Marco; Moretti, Giacomo; Sponchioni, Mattia; Moscatelli, Davide

doi:10.1016/j.ijpharm.2021.120956

Cited by 6 publications

(5 citation statements)

References 152 publications

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“…Compared with the two-dimensional structure, the three-dimensional cubic cage structure has a larger cage diameter, but a smaller pore entrance and pore channel, which is more conducive to drug administration [ 26 , 27 , 28 ]. Therefore, it is more meaningful to use SBA-16 as a nano-drug carrier in this study [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, pH-responsive composites prepared with SBA-16 as the carrier, indoleomycin as the carrier center, and gel polymer as the coating agent have not been reported.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

Shi

Liu

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

Shi

Liu

et al. 2023

Heliyon

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“…Healthcare-associated infections (HCAIs) are infections that begin 48 h or more after hospitalization or within 30 days after receiving healthcare, and they constitute the second most frequent adverse event suffered by hospitalized patients [ 1 ]. Thus, 5–15% of these patients acquire HCAIs [ 1 ], which represents more than 4 million admitted patients and 7 billion EUR in direct costs per year in Europe [ 2 ]. HCAIs cause prolonged hospitalization, high morbidity and mortality risks, the development of antibiotic-resistant microorganisms, and high costs [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, 5–15% of these patients acquire HCAIs [ 1 ], which represents more than 4 million admitted patients and 7 billion EUR in direct costs per year in Europe [ 2 ]. HCAIs cause prolonged hospitalization, high morbidity and mortality risks, the development of antibiotic-resistant microorganisms, and high costs [ 2 ]. Therefore, the goal must be to avoid the risk of these adverse events between patients and healthcare workers.…”

Section: Introductionmentioning

confidence: 99%

Disinfection of Reusable Laryngoscopes: A Survey about the Clinical Practice in Spain

et al. 2023

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Airway device-associated infections resulting from the cross-contamination of reusable laryngoscopes are one of the main causes of healthcare-associated infections. Laryngoscope blades are highly contaminated with various pathogens, including Gram-negative bacilli, which can cause prolonged hospitalization, high morbidity and mortality risks, the development of antibiotic-resistant microorganisms, and significant costs. Despite the Centers for Disease Control and Prevention and the American Society of Anesthesiologists’ recommendations, this national survey of 248 Spanish anesthesiologists showed that there is great variability in the processing of reusable laryngoscopes in Spain. Nearly a third of the respondents did not have an institutional disinfection protocol, and 45% of them did not know the disinfection procedure used. Good practices for the prevention and control of cross-contamination can be ensured through compliance with evidence-based guidelines, education of healthcare providers, and audits of clinical practices.

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“…In non-leaching polymers, it is indispensable for an antibacterial effect that the bacteria come very close to the surface, but their effect is not exhausted. The field of such contact-killing antimicrobial polymer surfaces has been extensively reviewed [33][34][35][36][37][38]. Among the antimicrobial polymers (e.g., halamines, poly lysine, poly guanidine, quaternary nitrogen groups, antimicrobial peptides [39]), quaternary ammonium compounds (QAC) are probably the most widely used and studied compounds [40,41].…”

Section: Introductionmentioning

confidence: 99%

Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures

et al. 2022

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The antibacterial activity of different antibiotic and metal-free thin polymer coatings was investigated. The films comprised quaternary ammonium compounds (QAC) based on a vinyl benzyl chloride (VBC) building block. Two monomeric QAC of different alkyl chain lengths were prepared, and then polymerized by two different polymerization processes to apply them onto Ti surfaces. At first, the polymeric layer was generated directly on the surface by atom transfer radical polymerization (ATRP). For comparison purposes, in a classical route a copolymerization of the QAC-containing monomers with a metal adhesion mediating phosphonate (VBPOH) monomers was carried out and the Ti surfaces were coated via drop coating. The different coatings were characterized by X-ray photoelectron spectroscopy (XPS) illustrating a thickness in the nanomolecular range. The cytocompatibility in vitro was confirmed by both live/dead and WST-1 assay. The antimicrobial activity was evaluated by two different assays (CFU and BTG, resp.,), showing for both coating processes similar results to kill bacteria on contact. These antibacterial coatings present a simple method to protect metallic devices against microbial contamination.

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Health care-associated infections: Controlled delivery of cationic antiseptics from polymeric excipients

Cited by 6 publications

References 152 publications

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

Disinfection of Reusable Laryngoscopes: A Survey about the Clinical Practice in Spain

Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures

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